PLEKHG4B (pleckstrin homology and RhoGEF domain containing G4B)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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153478 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Pleckstrin homology and RhoGEF domain containing G4B |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PLEKHG4B |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ARHGEF48 |
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Chromosome
Chromosome number
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5 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5p15.33 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q96PX9 | ||||||||||
| Protein name | Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B) | ||||||||||
| Protein function | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. Plays a role in actin cytoskeletal remodeling in the late stage of cell-cell junction formation by regulating the cont | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 1271 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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