PLEKHG4B (pleckstrin homology and RhoGEF domain containing G4B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 153478 |
| Gene name | Pleckstrin homology and RhoGEF domain containing G4B |
| Gene symbol | PLEKHG4B |
| Synonyms (NCBI Gene) |
ARHGEF48
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| Chromosome | 5 |
| Chromosome location | 5p15.33 |
| Summary | This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017] |
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miRNA
miRNA information provided by mirtarbase database.
606
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q96PX9 | ||||||||||
| Protein name | Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B) | ||||||||||
| Protein function | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. Plays a role in actin cytoskeletal remodeling in the late stage of cell-cell junction formation by regulating the cont | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 1271 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
6
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