TMEM161B (transmembrane protein 161B)

Gene

• Entrez ID: 153396
• Gene name: Transmembrane protein 161B
• Gene symbol: TMEM161B
• Synonyms (NCBI Gene): FLB3342, PRO1313
• Chromosome: 5
• Chromosome location: 5q14.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026084	hsa-miR-196a-5p	Sequencing	20371350
MIRT665818	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT665817	hsa-miR-190b	HITS-CLIP	23824327
MIRT665816	hsa-miR-4307	HITS-CLIP	23824327
MIRT665815	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT553565	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT553564	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT553562	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT553563	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT553561	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT553560	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT553559	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT553558	hsa-miR-1244	PAR-CLIP	21572407
MIRT553557	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT553556	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT553555	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT553554	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT553553	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT553552	hsa-miR-513c-5p	PAR-CLIP	21572407
MIRT553551	hsa-miR-514b-5p	PAR-CLIP	21572407
MIRT665818	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT665817	hsa-miR-190b	HITS-CLIP	23824327
MIRT665816	hsa-miR-4307	HITS-CLIP	23824327
MIRT665815	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT553565	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT553564	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT553562	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT553563	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT553561	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT553560	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT553559	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT553558	hsa-miR-1244	PAR-CLIP	21572407
MIRT553557	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT553556	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT553555	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT553554	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT553553	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT553552	hsa-miR-513c-5p	PAR-CLIP	21572407
MIRT553551	hsa-miR-514b-5p	PAR-CLIP	21572407
MIRT1431763	hsa-miR-1206	CLIP-seq
MIRT1431764	hsa-miR-128	CLIP-seq
MIRT1431765	hsa-miR-132	CLIP-seq
MIRT1431766	hsa-miR-1470	CLIP-seq
MIRT1431767	hsa-miR-194	CLIP-seq
MIRT1431768	hsa-miR-212	CLIP-seq
MIRT1431769	hsa-miR-24	CLIP-seq
MIRT1431770	hsa-miR-3064-3p	CLIP-seq
MIRT1431771	hsa-miR-31	CLIP-seq
MIRT1431772	hsa-miR-3133	CLIP-seq
MIRT1431773	hsa-miR-3160-5p	CLIP-seq
MIRT1431774	hsa-miR-3182	CLIP-seq
MIRT1431775	hsa-miR-3926	CLIP-seq
MIRT1431776	hsa-miR-3943	CLIP-seq
MIRT1431777	hsa-miR-4273	CLIP-seq
MIRT1431778	hsa-miR-4282	CLIP-seq
MIRT1431779	hsa-miR-4284	CLIP-seq
MIRT1431780	hsa-miR-4323	CLIP-seq
MIRT1431781	hsa-miR-4328	CLIP-seq
MIRT1431782	hsa-miR-4422	CLIP-seq
MIRT1431783	hsa-miR-4424	CLIP-seq
MIRT1431784	hsa-miR-4445	CLIP-seq
MIRT1431785	hsa-miR-4511	CLIP-seq
MIRT1431786	hsa-miR-4659a-3p	CLIP-seq
MIRT1431787	hsa-miR-4659b-3p	CLIP-seq
MIRT1431788	hsa-miR-4667-3p	CLIP-seq
MIRT1431789	hsa-miR-4677-5p	CLIP-seq
MIRT1431790	hsa-miR-4680-5p	CLIP-seq
MIRT1431791	hsa-miR-4699-5p	CLIP-seq
MIRT1431792	hsa-miR-4709-3p	CLIP-seq
MIRT1431793	hsa-miR-4755-5p	CLIP-seq
MIRT1431794	hsa-miR-513c	CLIP-seq
MIRT1431795	hsa-miR-520d-5p	CLIP-seq
MIRT1431796	hsa-miR-524-5p	CLIP-seq
MIRT1431797	hsa-miR-548s	CLIP-seq
MIRT1431798	hsa-miR-642a	CLIP-seq
MIRT2129431	hsa-miR-181a	CLIP-seq
MIRT2129432	hsa-miR-181b	CLIP-seq
MIRT2129433	hsa-miR-181c	CLIP-seq
MIRT2129434	hsa-miR-181d	CLIP-seq
MIRT2129435	hsa-miR-216a	CLIP-seq
MIRT2129436	hsa-miR-216b	CLIP-seq
MIRT2129437	hsa-miR-2276	CLIP-seq
MIRT2129438	hsa-miR-3143	CLIP-seq
MIRT2129439	hsa-miR-4262	CLIP-seq
MIRT2129440	hsa-miR-4772-3p	CLIP-seq
MIRT2129441	hsa-miR-4803	CLIP-seq
MIRT2129442	hsa-miR-544	CLIP-seq
MIRT2129443	hsa-miR-656	CLIP-seq
MIRT2129444	hsa-miR-891b	CLIP-seq
MIRT1431763	hsa-miR-1206	CLIP-seq
MIRT2350980	hsa-miR-125a-5p	CLIP-seq
MIRT2350981	hsa-miR-125b	CLIP-seq
MIRT2350982	hsa-miR-196a	CLIP-seq
MIRT2350983	hsa-miR-196b	CLIP-seq
MIRT2350984	hsa-miR-214	CLIP-seq
MIRT2350985	hsa-miR-299-5p	CLIP-seq
MIRT1431771	hsa-miR-31	CLIP-seq
MIRT2350986	hsa-miR-3125	CLIP-seq
MIRT2350987	hsa-miR-3619-5p	CLIP-seq
MIRT2350988	hsa-miR-3620	CLIP-seq
MIRT2350989	hsa-miR-3916	CLIP-seq
MIRT2350990	hsa-miR-3973	CLIP-seq
MIRT2350991	hsa-miR-4251	CLIP-seq
MIRT2350992	hsa-miR-4291	CLIP-seq
MIRT2350993	hsa-miR-4319	CLIP-seq
MIRT2350994	hsa-miR-4324	CLIP-seq
MIRT2350995	hsa-miR-4760-3p	CLIP-seq
MIRT2350996	hsa-miR-4797-5p	CLIP-seq
MIRT1431795	hsa-miR-520d-5p	CLIP-seq
MIRT1431796	hsa-miR-524-5p	CLIP-seq
MIRT2350997	hsa-miR-548a-5p	CLIP-seq
MIRT2350998	hsa-miR-548ab	CLIP-seq
MIRT2350999	hsa-miR-548ak	CLIP-seq
MIRT2351000	hsa-miR-548b-5p	CLIP-seq
MIRT2351001	hsa-miR-548c-5p	CLIP-seq
MIRT2351002	hsa-miR-548d-5p	CLIP-seq
MIRT2351003	hsa-miR-548h	CLIP-seq
MIRT2351004	hsa-miR-548i	CLIP-seq
MIRT2351005	hsa-miR-548j	CLIP-seq
MIRT2351006	hsa-miR-548w	CLIP-seq
MIRT2351007	hsa-miR-548y	CLIP-seq
MIRT2351008	hsa-miR-552	CLIP-seq
MIRT2351009	hsa-miR-559	CLIP-seq
MIRT2351010	hsa-miR-580	CLIP-seq
MIRT2351011	hsa-miR-657	CLIP-seq
MIRT2351012	hsa-miR-761	CLIP-seq
MIRT2351013	hsa-miR-922	CLIP-seq
MIRT2350980	hsa-miR-125a-5p	CLIP-seq
MIRT2350981	hsa-miR-125b	CLIP-seq
MIRT1431764	hsa-miR-128	CLIP-seq
MIRT1431765	hsa-miR-132	CLIP-seq
MIRT2644599	hsa-miR-190	CLIP-seq
MIRT1431767	hsa-miR-194	CLIP-seq
MIRT2644600	hsa-miR-2054	CLIP-seq
MIRT1431768	hsa-miR-212	CLIP-seq
MIRT2644601	hsa-miR-300	CLIP-seq
MIRT1431770	hsa-miR-3064-3p	CLIP-seq
MIRT2350986	hsa-miR-3125	CLIP-seq
MIRT2644602	hsa-miR-323-3p	CLIP-seq
MIRT2644603	hsa-miR-3617	CLIP-seq
MIRT2350988	hsa-miR-3620	CLIP-seq
MIRT2644604	hsa-miR-374c	CLIP-seq
MIRT2644605	hsa-miR-381	CLIP-seq
MIRT2350989	hsa-miR-3916	CLIP-seq
MIRT2350991	hsa-miR-4251	CLIP-seq
MIRT2644606	hsa-miR-4261	CLIP-seq
MIRT2350993	hsa-miR-4319	CLIP-seq
MIRT2350994	hsa-miR-4324	CLIP-seq
MIRT2644607	hsa-miR-4496	CLIP-seq
MIRT2350995	hsa-miR-4760-3p	CLIP-seq
MIRT2644608	hsa-miR-4762-3p	CLIP-seq
MIRT2644609	hsa-miR-4775	CLIP-seq
MIRT2350996	hsa-miR-4797-5p	CLIP-seq
MIRT2644610	hsa-miR-494	CLIP-seq
MIRT2351010	hsa-miR-580	CLIP-seq
MIRT2644611	hsa-miR-590-3p	CLIP-seq
MIRT2644612	hsa-miR-641	CLIP-seq
MIRT2644613	hsa-miR-655	CLIP-seq
MIRT2350980	hsa-miR-125a-5p	CLIP-seq
MIRT2350981	hsa-miR-125b	CLIP-seq
MIRT2350986	hsa-miR-3125	CLIP-seq
MIRT2350989	hsa-miR-3916	CLIP-seq
MIRT2350991	hsa-miR-4251	CLIP-seq
MIRT2644606	hsa-miR-4261	CLIP-seq
MIRT2350993	hsa-miR-4319	CLIP-seq
MIRT2350994	hsa-miR-4324	CLIP-seq
MIRT2644607	hsa-miR-4496	CLIP-seq
MIRT2350996	hsa-miR-4797-5p	CLIP-seq
MIRT2644610	hsa-miR-494	CLIP-seq
MIRT2351010	hsa-miR-580	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	IEA
GO:0002027	Process	Regulation of heart rate	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0016020	Component	Membrane	IEA
GO:0098901	Process	Regulation of cardiac muscle cell action potential	IEA
GO:0098901	Process	Regulation of cardiac muscle cell action potential	ISS

Other IDs

• MIM: 621178
• HGNC: 28483
• e!Ensembl: ENSG00000164180

Protein

• UniProt ID: Q8NDZ6
• Protein name: Transmembrane protein 161B
• Protein function: Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (By similarity). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10268	Tmemb_161AB	2 → 485	Predicted transmembrane protein 161AB	Family

• Sequence:

  MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKT
  KKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATVVYLV
  TEVYYNFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFV
  KAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQSPVSKLTFKFFLAIFCSFIG
  AFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGK
  ESIPLMTEATFDTLRLWLIILLCALRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVEL
  QKMVARVFYYLCVIALQYVAPLVMLLHTTLLLKTLGNHSWGIYPESISTLPVDNSLLSNS
  VYSELPSAEGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFY
  HQYLTVA

• Sequence length: 487

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TMEM161B-related lissencephaly	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Attention Deficit Disorder with Hyperactivity	Associate	31575856	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Associate	33828235	★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Associate	33828235	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Associate	34046994	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	34046994	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Inhibit	34046994	★☆☆☆☆ Found in Text Mining only
Mood Disorders	Associate	33828235	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	37227248	★☆☆☆☆ Found in Text Mining only
Pulpitis	Associate	37208635	★☆☆☆☆ Found in Text Mining only