Gene Gene information from NCBI Gene database.
Entrez ID 153222
Gene name CREB3 regulatory factor
Gene symbol CREBRF
Synonyms (NCBI Gene)
C5orf41LRF
Chromosome 5
Chromosome location 5q35.1
miRNA miRNA information provided by mirtarbase database.
411
miRTarBase ID miRNA Experiments Reference
MIRT005103 hsa-miR-155-5p Microarray 19193853
MIRT016126 hsa-miR-421 Sequencing 20371350
MIRT017940 hsa-miR-335-5p Microarray 18185580
MIRT028082 hsa-miR-93-5p Sequencing 20371350
MIRT045087 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 18391022
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 16940180
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16940180
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617109 24050 ENSG00000164463
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IUR6
Protein name CREB3 regulatory factor (Luman recruitment factor) (LRF)
Protein function Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
Family and domains
Sequence
MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFL
SLEDCKDIENLESFTDVLDNEGALTSNWEQWDTYCEDLTKYTKLTSCDIWGTKEVDYLGL
DDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSLFSVKQNPLPSSFPGKKITSR
AAAPVCSSKTLQAEVPLSDCVQKASKPTSSTQIMVKTNMYHNEKVNFHVECKDYVKKAKV
KINPVQQSRPLLSQIHTDAAKENTCYCGAVAKRQEKKGMEPLQGHATPALPFKETQELLL
SPLPQEGPGSLAAGESSSLSASTSVSDSSQKKEEHNYSLFVSDNLGEQPTKCSPEEDEED
EEDVDDEDHDEGFGSEHELSENEEEEEEEEDYEDDKDDDISDTFSEPGYENDSVEDLKEV
TSISSRKRGKRRYFWEYSEQLTPSQQERMLRPSEWNRDTLPSNMYQKNGLHHGKYAVKKS
RRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRL
KKKAQYEANKVKLWGLNTEYDNLLFVINSIKQEIVNRVQNPRDERGPNMGQKLEILIKDT
LGLPVAGQTSEFVNQVLEKTAEGNPTGGLVGLRIPTSKV
Sequence length 639
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    CREB3 factors activate genes
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DYSLEXIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 32699331
★☆☆☆☆
Found in Text Mining only
Anemia Sickle Cell Associate 32917636
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 34990474
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Associate 31280340, 32884101, 34340601
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 31280340, 35144939, 36284436
★☆☆☆☆
Found in Text Mining only
Glioma Associate 27163161
★☆☆☆☆
Found in Text Mining only
Hypoxia Associate 27163161
★☆☆☆☆
Found in Text Mining only
Kidney Failure Chronic Associate 31280340
★☆☆☆☆
Found in Text Mining only
Neoplasms Adipose Tissue Associate 32491157
★☆☆☆☆
Found in Text Mining only
Obesity Associate 27455349, 31280340, 32190945, 32884101, 35606300
★☆☆☆☆
Found in Text Mining only