Gene Gene information from NCBI Gene database.
Entrez ID 153129
Gene name Solute carrier family 38 member 9
Gene symbol SLC38A9
Synonyms (NCBI Gene)
SNAT9URLC11
Chromosome 5
Chromosome location 5q11.2
miRNA miRNA information provided by mirtarbase database.
411
miRTarBase ID miRNA Experiments Reference
MIRT671509 hsa-miR-5197-5p HITS-CLIP 23824327
MIRT671508 hsa-miR-130a-3p HITS-CLIP 23824327
MIRT671507 hsa-miR-130b-3p HITS-CLIP 23824327
MIRT671506 hsa-miR-301a-3p HITS-CLIP 23824327
MIRT671505 hsa-miR-301b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA
GO:0003333 Process Amino acid transmembrane transport IDA 25567906, 29053970
GO:0005085 Function Guanyl-nucleotide exchange factor activity IDA 30181260
GO:0005515 Function Protein binding IPI 25561175, 25567906, 28336668, 30956113, 32433612, 33961781
GO:0005764 Component Lysosome IDA 25561175, 25567906
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616203 26907 ENSG00000177058
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBW4
Protein name Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)
Protein function Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels (PubMed:25561175, PubMed:25567906, PubMed:29053970). Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 compl
PDB 6WJ2 , 6WJ3 , 8DHB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01490 Aa_trans 115 254 Transmembrane amino acid transporter protein Family
PF01490 Aa_trans 271 561 Transmembrane amino acid transporter protein Family
Sequence
Sequence length 561
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mTOR signaling pathway   Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Colorectal Neoplasms Associate 27609023
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 36364703
★☆☆☆☆
Found in Text Mining only
Diabetic Angiopathies Associate 36364703
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Associate 24762746
★☆☆☆☆
Found in Text Mining only
Renal Insufficiency Chronic Associate 36364703
★☆☆☆☆
Found in Text Mining only