Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
153
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenoceptor beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADRB1
Synonyms (NCBI Gene) Gene synonyms aliases
ADRB1R, B1AR, BETA1AR, FNSS2, RHR
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1801253 G>A,C Drug-response Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT717492 hsa-miR-188-5p HITS-CLIP 19536157
MIRT717491 hsa-miR-6866-3p HITS-CLIP 19536157
MIRT717490 hsa-miR-186-3p HITS-CLIP 19536157
MIRT717489 hsa-miR-3124-3p HITS-CLIP 19536157
MIRT717488 hsa-miR-2113 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001996 Process Positive regulation of heart rate by epinephrine-norepinephrine IBA 21873635
GO:0001997 Process Positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
GO:0002024 Process Diet induced thermogenesis IEA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA 21873635
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
109630 285 ENSG00000043591
Protein
UniProt ID P08588
Protein name Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)
Protein function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G
PDB 2LSQ , 7BTS , 7BU6 , 7BU7 , 7BVQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 75 377 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 477
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Adrenergic signaling in cardiomyocytes
Gap junction
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion
Chemical carcinogenesis - receptor activation
Dilated cardiomyopathy
  Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Cardiomyopathy, Dilated, Cardiomyopathy, Familial Idiopathic rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
9554809
Diabetes mellitus Diabetes Mellitus rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
18378355
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
17003101
Hypertension Hypertensive disease rs13306026 9260993, 10673262
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 14502278, 15816327, 12374873, 7586371, 21516734 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 7586371, 12374873, 14502278, 15816327, 21516734 ClinVar
Mental depression Mental Depression, Depressive disorder 18797399, 24758696 ClinVar
Myocardial infarction Myocardial Failure 7586371, 15816327, 14502278, 12374873, 21516734 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 37952358
Arrhythmias Cardiac Associate 21617318, 22664639, 37102236, 38138160
Atherosclerosis Associate 24371822
Atrial Fibrillation Associate 20625396, 22192668, 22499333, 24159564, 24332148, 24982877, 34270905
Bipolar Disorder Associate 29230810
Body Weight Associate 29587766
Breast Neoplasms Associate 33234738, 34930307, 35113855
Cachexia Stimulate 20426789
Carcinoma Pancreatic Ductal Associate 22797009
Cardiomyopathies Associate 21617318, 37102236