KLB (klotho beta)

Gene

• Entrez ID: 152831
• Gene name: Klotho beta
• Gene symbol: KLB
• Synonyms (NCBI Gene): BKL
• Chromosome: 4
• Chromosome location: 4p14

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006874	hsa-miR-34a-5p	Luciferase reporter assay	22988100
MIRT048903	hsa-miR-93-5p	CLASH	23622248
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT650011	hsa-miR-764	HITS-CLIP	23313552
MIRT696279	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT650015	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650014	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT650013	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650012	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650011	hsa-miR-764	HITS-CLIP	23824327
MIRT650010	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650009	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT650008	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT650007	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT650006	hsa-miR-6131	HITS-CLIP	23824327
MIRT650005	hsa-miR-7641	HITS-CLIP	23824327
MIRT650004	hsa-miR-548s	HITS-CLIP	23824327
MIRT650003	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT650002	hsa-miR-588	HITS-CLIP	23824327
MIRT650001	hsa-miR-4435	HITS-CLIP	23824327
MIRT650000	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT649999	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT649998	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT650011	hsa-miR-764	HITS-CLIP	23313552
MIRT696279	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT650015	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650014	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT650013	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650012	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650011	hsa-miR-764	HITS-CLIP	23824327
MIRT650010	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650009	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT650008	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT650007	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT650006	hsa-miR-6131	HITS-CLIP	23824327
MIRT650005	hsa-miR-7641	HITS-CLIP	23824327
MIRT650004	hsa-miR-548s	HITS-CLIP	23824327
MIRT650003	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT650002	hsa-miR-588	HITS-CLIP	23824327
MIRT650001	hsa-miR-4435	HITS-CLIP	23824327
MIRT650000	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT649999	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT649998	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1095494	hsa-miR-101	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT1095496	hsa-miR-1227	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT1095498	hsa-miR-1273f	CLIP-seq
MIRT1095499	hsa-miR-129-3p	CLIP-seq
MIRT1095500	hsa-miR-135a	CLIP-seq
MIRT1095501	hsa-miR-135b	CLIP-seq
MIRT1095502	hsa-miR-144	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT1095506	hsa-miR-2053	CLIP-seq
MIRT1095507	hsa-miR-21	CLIP-seq
MIRT1095508	hsa-miR-3168	CLIP-seq
MIRT1095509	hsa-miR-3170	CLIP-seq
MIRT1095510	hsa-miR-3923	CLIP-seq
MIRT1095511	hsa-miR-3978	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095513	hsa-miR-4252	CLIP-seq
MIRT1095514	hsa-miR-4257	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT1095517	hsa-miR-4330	CLIP-seq
MIRT1095518	hsa-miR-4419a	CLIP-seq
MIRT1095519	hsa-miR-4474-5p	CLIP-seq
MIRT1095520	hsa-miR-4510	CLIP-seq
MIRT1095521	hsa-miR-4659a-5p	CLIP-seq
MIRT1095522	hsa-miR-4659b-5p	CLIP-seq
MIRT1095523	hsa-miR-4693-5p	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT1095526	hsa-miR-4776-3p	CLIP-seq
MIRT1095527	hsa-miR-4786-3p	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095530	hsa-miR-548ac	CLIP-seq
MIRT1095531	hsa-miR-548ae	CLIP-seq
MIRT1095532	hsa-miR-548aj	CLIP-seq
MIRT1095533	hsa-miR-548am	CLIP-seq
MIRT1095534	hsa-miR-548d-3p	CLIP-seq
MIRT1095535	hsa-miR-548x	CLIP-seq
MIRT1095536	hsa-miR-548z	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT1095538	hsa-miR-569	CLIP-seq
MIRT1095539	hsa-miR-582-5p	CLIP-seq
MIRT1095540	hsa-miR-590-5p	CLIP-seq
MIRT1095541	hsa-miR-628-3p	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1922196	hsa-miR-4503	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT2025657	hsa-miR-129-5p	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2025658	hsa-miR-186	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2025659	hsa-miR-3133	CLIP-seq
MIRT2025660	hsa-miR-3135	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT2025664	hsa-miR-3929	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2025666	hsa-miR-4317	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT2025667	hsa-miR-4419b	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT1095519	hsa-miR-4474-5p	CLIP-seq
MIRT2025669	hsa-miR-4478	CLIP-seq
MIRT2025670	hsa-miR-4520a-3p	CLIP-seq
MIRT2025671	hsa-miR-4520b-3p	CLIP-seq
MIRT2025672	hsa-miR-4529-3p	CLIP-seq
MIRT1095521	hsa-miR-4659a-5p	CLIP-seq
MIRT1095522	hsa-miR-4659b-5p	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2025677	hsa-miR-645	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095496	hsa-miR-1227	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT2256832	hsa-miR-130a	CLIP-seq
MIRT2256833	hsa-miR-130b	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT2256835	hsa-miR-183	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256838	hsa-miR-24	CLIP-seq
MIRT2256839	hsa-miR-301a	CLIP-seq
MIRT2256840	hsa-miR-301b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT2025660	hsa-miR-3135	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT2256846	hsa-miR-3666	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT2025664	hsa-miR-3929	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2256849	hsa-miR-4284	CLIP-seq
MIRT2256850	hsa-miR-4295	CLIP-seq
MIRT2025666	hsa-miR-4317	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT1095517	hsa-miR-4330	CLIP-seq
MIRT2025667	hsa-miR-4419b	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT2025669	hsa-miR-4478	CLIP-seq
MIRT2256852	hsa-miR-454	CLIP-seq
MIRT2256853	hsa-miR-4663	CLIP-seq
MIRT2256854	hsa-miR-4715-3p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2256855	hsa-miR-4746-3p	CLIP-seq
MIRT1095526	hsa-miR-4776-3p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2256863	hsa-miR-564	CLIP-seq
MIRT2025677	hsa-miR-645	CLIP-seq
MIRT2256864	hsa-miR-922	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2558287	hsa-miR-3150a-5p	CLIP-seq
MIRT2558288	hsa-miR-3150b-5p	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT2558289	hsa-miR-4312	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT2558290	hsa-miR-4731-5p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2558291	hsa-miR-640	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT2025657	hsa-miR-129-5p	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2558287	hsa-miR-3150a-5p	CLIP-seq
MIRT2558288	hsa-miR-3150b-5p	CLIP-seq
MIRT1095509	hsa-miR-3170	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2558289	hsa-miR-4312	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2558290	hsa-miR-4731-5p	CLIP-seq
MIRT2683527	hsa-miR-4735-5p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2683528	hsa-miR-4775	CLIP-seq
MIRT2683529	hsa-miR-4794	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2683530	hsa-miR-590-3p	CLIP-seq
MIRT2558291	hsa-miR-640	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0005104	Function	Fibroblast growth factor receptor binding	IPI	17627937
GO:0005515	Function	Protein binding	IPI	19059246
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0017134	Function	Fibroblast growth factor binding	IEA
GO:0017134	Function	Fibroblast growth factor binding	IPI	18829467, 19117008
GO:0090080	Process	Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IEA

Other IDs

• MIM: 611135
• HGNC: 15527
• e!Ensembl: ENSG00000134962

Protein

• UniProt ID: Q86Z14
• Protein name: Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
• Protein function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity
• PDB: 5VAK, 5VAN, 5VAQ, 5WI9, 6NFJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00232	Glyco_hydro_1	77 → 388	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	376 → 508	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	517 → 967	Glycosyl hydrolase family 1	Domain

• Sequence:

  MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAI
  WSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKN
  VSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLD
  ALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIH
  NPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITL
  GSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEK
  HEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
  TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFY
  VDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVA
  SSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFA
  LDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADG
  WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHA
  LAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTG
  DYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSR
  YDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDD
  RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNK
  VISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQ
  KRRKFWKAKNLQHIPLKKGKRVVS

• Sequence length: 1044

Pathways

KEGG:

Thermogenesis

Reactome:

PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Male infertility with azoospermia or oligozoospermia due to single gene mutation	Likely pathogenic	rs2474965849	RCV003991614

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Amenorrhea	Uncertain significance	rs560220050, rs1487572959	RCV001849743 RCV001849744
Hepatocellular carcinoma	Likely benign	rs369568090	RCV005930866
Hypogonadotropic hypogonadism	Conflicting classifications of pathogenicity	rs549659598	RCV006440082
KLB-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity	rs4975017, rs35372803, rs10003369, rs147899701, rs138076201, rs200309567, rs147372707, rs549659598, rs35733674, rs147916209, rs146152443, rs143809363, rs116274139, rs765099477	RCV003984077 RCV003978696 RCV003916286 RCV003933588 RCV003944220 RCV003927233 RCV003914419 RCV003918226 RCV003895421 RCV003910374 RCV003955795 RCV003920793 RCV003958099 RCV003978059
Martsolf syndrome 1	Uncertain significance	rs200211529, rs1743421653	RCV002305664 RCV002305665
Melanoma	Benign	rs144494424	RCV005902879
Ocular motility disease	Uncertain significance	rs567666148	RCV003883450

Associations from Text Mining
Disease Name	Relationship Type	References
Actin Accumulation Myopathy	Associate	33640795
Alopecia Areata	Associate	39177325
Breast Neoplasms	Associate	23317273
Carcinogenesis	Associate	29749458
Carcinoma Hepatocellular	Associate	22439738, 36179047
Carcinoma Non Small Cell Lung	Inhibit	31695781
Chemical and Drug Induced Liver Injury	Associate	31655133, 33640795
Cholangiocarcinoma	Associate	28445152
Diabetes Gestational	Associate	29734515
Diabetes Gestational	Inhibit	34912302
Diarrhea	Associate	21396369
Endometrial Neoplasms	Inhibit	26824324, 35762530
Endometrial Neoplasms	Associate	30393845
Fatty Liver	Associate	33640795
Fibrosis	Associate	29699061, 31655133, 33640795
Graves Ophthalmopathy	Associate	37900130
HIV Infections	Associate	29661866
Inflammation	Associate	29699061, 31548436, 31655133, 33640795
Irritable Bowel Syndrome	Associate	21396369, 22271411
Liver Cirrhosis	Associate	29699061, 33640795
Lymphatic Metastasis	Inhibit	31695781
Neoplasm Metastasis	Associate	30393845
Neoplasms	Inhibit	29749458
Neoplasms	Associate	30593273, 31695781
Non alcoholic Fatty Liver Disease	Associate	31548436, 31655133
Obesity	Associate	31548436, 33640795
Prostatic Neoplasms	Inhibit	29749458
Prostatitis	Inhibit	29749458
Tertiary Lymphoid Structures	Associate	30393845
Trigeminal Neuralgia	Associate	38158702
Vitiligo	Associate	39177325