NEK10 (NIMA related kinase 10)

Gene

• Entrez ID: 152110
• Gene name: NIMA related kinase 10
• Gene symbol: NEK10
• Synonyms (NCBI Gene): CILD44
• Chromosome: 3
• Chromosome location: 3p24.1

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs766982731	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, genic downstream transcript variant, missense variant
rs1253689023	C>G	Pathogenic	Genic upstream transcript variant, 5 prime UTR variant, intron variant
rs1575215909	G>A	Pathogenic	Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs1575588483	->A	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant, genic upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180073	hsa-miR-24	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180076	hsa-miR-4284	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT2281433	hsa-miR-23a	CLIP-seq
MIRT2281434	hsa-miR-23b	CLIP-seq
MIRT2281435	hsa-miR-23c	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	20956560
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0006468	Process	Protein phosphorylation	IDA	20956560
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	20956560
GO:0043406	Process	Positive regulation of MAP kinase activity	IMP	20956560
GO:0046872	Function	Metal ion binding	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	20956560
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0120197	Process	Mucociliary clearance	IMP	31959991
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IBA
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IMP	20956560
GO:1902911	Component	Protein kinase complex	IDA	20956560

Other IDs

• MIM: 618726
• HGNC: 18592
• e!Ensembl: ENSG00000163491

Protein

• UniProt ID: Q6ZWH5
• Protein name: Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)
• Protein function: Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	519 → 783	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the lung. {ECO:0000269|PubMed:31959991}.
• Sequence:

  MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS
  EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS
  REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH
  TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ
  ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL
  HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA
  NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL
  ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA
  YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS
  GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL
  YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN
  IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILY
  QMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVS
  SMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEK
  ASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYS
  EVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLP
  LDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAV
  SQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKS
  EIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTV
  IEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR

• Sequence length: 1172

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ciliary dyskinesia, primary, 44	Pathogenic; Likely pathogenic	rs2472395615, rs764245230, rs1253689023, rs1575588483, rs1575215909, rs766982731	RCV002283668 RCV003989019 RCV001004051 RCV001004052 RCV001004053 RCV001004054

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
NEK10-related disorder	Uncertain significance	rs370504122	RCV003408690

Associations from Text Mining
Disease Name	Relationship Type	References
Adenoma	Stimulate	35260162
Breast Neoplasms	Associate	19330027, 24943594, 25881232, 29898891
Bronchiectasis	Associate	31959991
Ciliary Motility Disorders	Associate	32414360, 37998386
Ciliopathies	Associate	31959991
Respiratory Insufficiency	Associate	31959991