Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	152110
Gene name Gene Name - the full gene name approved by the HGNC.	NIMA related kinase 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NEK10
Synonyms (NCBI Gene) Gene synonyms aliases	CILD44
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p24.1

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs766982731	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, genic downstream transcript variant, missense variant
rs1253689023	C>G	Pathogenic	Genic upstream transcript variant, 5 prime UTR variant, intron variant
rs1575215909	G>A	Pathogenic	Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs1575588483	->A	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant, genic upstream transcript variant

Show/Hide all(34)

miRTarBase ID	miRNA	Experiments
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180073	hsa-miR-24	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180076	hsa-miR-4284	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT2281433	hsa-miR-23a	CLIP-seq
MIRT2281434	hsa-miR-23b	CLIP-seq
MIRT2281435	hsa-miR-23c	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	20956560
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0006468	Process	Protein phosphorylation	IDA	20956560
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	20956560
GO:0043406	Process	Positive regulation of MAP kinase activity	IMP	20956560
GO:0046872	Function	Metal ion binding	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	20956560
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0120197	Process	Mucociliary clearance	IMP	31959991
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IBA
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IMP	20956560
GO:1902911	Component	Protein kinase complex	IDA	20956560

MIM	HGNC	e!Ensembl
618726	18592	ENSG00000163491

Protein

UniProt ID

Q6ZWH5

Protein name

Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)

Protein function

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	519 → 783	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the lung. {ECO:0000269|PubMed:31959991}.

Sequence

MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS
EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS
REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH
TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ
ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL
HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA
NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL
ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA
YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS
GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL
YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN
IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILY
QMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVS
SMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEK
ASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYS
EVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLP
LDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAV
SQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKS
EIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTV
IEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR

Sequence length

1172

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Ciliary dyskinesia	Ciliary dyskinesia, primary, 44	rs1575588483, rs1575215909, rs766982731, rs1253689023	N/A

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Breast Cancer	Postmenopausal breast cancer	N/A	N/A	GWAS
Breast cancer	Breast cancer (early onset), Breast cancer	N/A	N/A	GWAS
Cataract	Cataract	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Stimulate	35260162
Breast Neoplasms	Associate	19330027, 24943594, 25881232, 29898891
Bronchiectasis	Associate	31959991
Ciliary Motility Disorders	Associate	32414360, 37998386
Ciliopathies	Associate	31959991
Respiratory Insufficiency	Associate	31959991

NEK10 (NIMA related kinase 10)