XXYLT1 (xyloside xylosyltransferase 1)

Gene

• Entrez ID: 152002
• Gene name: Xyloside xylosyltransferase 1
• Gene symbol: XXYLT1
• Synonyms (NCBI Gene): C3orf21
• Chromosome: 3
• Chromosome location: 3q29

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	8982869
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	22117070
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	IBA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	IDA	8982869, 22117070
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030145	Function	Manganese ion binding	IDA	8982869
GO:0030145	Function	Manganese ion binding	IEA
GO:0035252	Function	UDP-xylosyltransferase activity	IDA	8982869
GO:0035252	Function	UDP-xylosyltransferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0140560	Function	Xylosyl alpha-1,3-xylosyltransferase activity	IBA
GO:0140560	Function	Xylosyl alpha-1,3-xylosyltransferase activity	IDA	22117070, 30169771
GO:0140560	Function	Xylosyl alpha-1,3-xylosyltransferase activity	IEA

Other IDs

• MIM: 614552
• HGNC: 26639
• e!Ensembl: ENSG00000173950

Protein

• UniProt ID: Q8NBI6
• Protein name: Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)
• Protein function: Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01501	Glyco_transf_8	113 → 369	Glycosyl transferase family 8	Family

• Sequence:

  MGLLRGGLPCARAMARLGAVRSHYCALLLAAALAVCAFYYLGSGRETFSSATKRLKEARA
  GAPAAPSPPALELARGSVAPAPGAKAKSLEGGGAGPVDYHLLMMFTKAEHNAALQAKARV
  ALRSLLRLAKFEAHEVLNLHFVSEEASREVAKGLLRELLPPAAGFKCKVIFHDVAVLTDK
  LFPIVEAMQKHFSAGLGTYYSDSIFFLSVAMHQIMPKEILQIIQLDLDLKFKTNIRELFE
  EFDSFLPGAIIGIAREMQPVYRHTFWQFRHENPQTRVGGPPPEGLPGFNSGVMLLNLEAM
  RQSPLYSRLLEPAQVQQLADKYHFRGHLGDQDFFTMIGMEHPKLFHVLDCTWNRQLCTWW
  RDHGYSDVFEAYFRCEGHVKIYHGNCNTPIPED

• Sequence length: 393

Pathways

KEGG:

Other types of O-glycan biosynthesis