CTSS (cathepsin S)

Gene

• Entrez ID: 1520
• Gene name: Cathepsin S
• Gene symbol: CTSS
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT704399	hsa-miR-8066	HITS-CLIP	23313552
MIRT704398	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT704397	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT704396	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT704395	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT704394	hsa-miR-4459	HITS-CLIP	23313552
MIRT704393	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT704392	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704391	hsa-miR-544b	HITS-CLIP	23313552
MIRT704390	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT704389	hsa-miR-4794	HITS-CLIP	23313552
MIRT704388	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT704387	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704386	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704385	hsa-miR-3672	HITS-CLIP	23313552
MIRT704384	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT440859	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440857	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440859	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727921	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727920	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727919	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727918	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440857	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT733948	hsa-miR-4498	Luciferase reporter assay, qRT-PCR	33013913
MIRT736399	hsa-miR-369-3p	qRT-PCR, Flow cytometry	33679688
MIRT736410	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT704399	hsa-miR-8066	HITS-CLIP	23313552
MIRT704398	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT704397	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT704396	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT704395	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT704394	hsa-miR-4459	HITS-CLIP	23313552
MIRT704393	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT704392	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704391	hsa-miR-544b	HITS-CLIP	23313552
MIRT704390	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT704389	hsa-miR-4794	HITS-CLIP	23313552
MIRT704388	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT704387	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704386	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704385	hsa-miR-3672	HITS-CLIP	23313552
MIRT704384	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916030	hsa-miR-4477a	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916038	hsa-miR-1275	CLIP-seq
MIRT916039	hsa-miR-135a	CLIP-seq
MIRT916040	hsa-miR-135b	CLIP-seq
MIRT916041	hsa-miR-140-3p	CLIP-seq
MIRT916042	hsa-miR-185	CLIP-seq
MIRT916043	hsa-miR-203	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916045	hsa-miR-3150a-3p	CLIP-seq
MIRT916046	hsa-miR-3163	CLIP-seq
MIRT916047	hsa-miR-3175	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT916048	hsa-miR-329	CLIP-seq
MIRT916049	hsa-miR-340	CLIP-seq
MIRT916050	hsa-miR-342-5p	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916051	hsa-miR-362-3p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT916055	hsa-miR-4269	CLIP-seq
MIRT916056	hsa-miR-4275	CLIP-seq
MIRT916057	hsa-miR-4306	CLIP-seq
MIRT916058	hsa-miR-4314	CLIP-seq
MIRT916059	hsa-miR-4428	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916060	hsa-miR-4505	CLIP-seq
MIRT916061	hsa-miR-4514	CLIP-seq
MIRT916062	hsa-miR-4525	CLIP-seq
MIRT916063	hsa-miR-4644	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916064	hsa-miR-4651	CLIP-seq
MIRT916065	hsa-miR-4664-5p	CLIP-seq
MIRT916066	hsa-miR-4665-5p	CLIP-seq
MIRT916067	hsa-miR-4667-5p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916068	hsa-miR-4690-5p	CLIP-seq
MIRT916069	hsa-miR-4692	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT916071	hsa-miR-4700-5p	CLIP-seq
MIRT916072	hsa-miR-4723-5p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916074	hsa-miR-4731-5p	CLIP-seq
MIRT916075	hsa-miR-4738-3p	CLIP-seq
MIRT916076	hsa-miR-4773	CLIP-seq
MIRT916077	hsa-miR-483-3p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT916079	hsa-miR-548g	CLIP-seq
MIRT916080	hsa-miR-604	CLIP-seq
MIRT916081	hsa-miR-608	CLIP-seq
MIRT916082	hsa-miR-625	CLIP-seq
MIRT916083	hsa-miR-637	CLIP-seq
MIRT916084	hsa-miR-647	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT916085	hsa-miR-939	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT1971642	hsa-miR-1827	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT1971643	hsa-miR-3545-3p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT1971644	hsa-miR-3929	CLIP-seq
MIRT1971645	hsa-miR-4267	CLIP-seq
MIRT916056	hsa-miR-4275	CLIP-seq
MIRT1971646	hsa-miR-4419b	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT1971647	hsa-miR-4478	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT1971648	hsa-miR-4649-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT1971649	hsa-miR-4680-5p	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT1971650	hsa-miR-4722-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT1971651	hsa-miR-940	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916068	hsa-miR-4690-5p	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT2465145	hsa-miR-1268	CLIP-seq
MIRT2465146	hsa-miR-1268b	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT2465149	hsa-miR-4486	CLIP-seq
MIRT916060	hsa-miR-4505	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2465152	hsa-miR-585	CLIP-seq
MIRT2510555	hsa-miR-103b	CLIP-seq
MIRT2510556	hsa-miR-106a	CLIP-seq
MIRT2510557	hsa-miR-106b	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT2465145	hsa-miR-1268	CLIP-seq
MIRT2465146	hsa-miR-1268b	CLIP-seq
MIRT2510558	hsa-miR-1279	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT2510559	hsa-miR-1323	CLIP-seq
MIRT2510560	hsa-miR-150	CLIP-seq
MIRT2510561	hsa-miR-17	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT2510562	hsa-miR-20a	CLIP-seq
MIRT2510563	hsa-miR-20b	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT2510564	hsa-miR-302a	CLIP-seq
MIRT2510565	hsa-miR-302b	CLIP-seq
MIRT2510566	hsa-miR-302c	CLIP-seq
MIRT2510567	hsa-miR-302d	CLIP-seq
MIRT2510568	hsa-miR-302e	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT2510569	hsa-miR-3148	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT2510570	hsa-miR-3613-3p	CLIP-seq
MIRT2510571	hsa-miR-3617	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT2510572	hsa-miR-371-5p	CLIP-seq
MIRT2510573	hsa-miR-371b-5p	CLIP-seq
MIRT2510574	hsa-miR-372	CLIP-seq
MIRT2510575	hsa-miR-373	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2510576	hsa-miR-3940-5p	CLIP-seq
MIRT2510577	hsa-miR-3977	CLIP-seq
MIRT2510578	hsa-miR-423-3p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT2510579	hsa-miR-4438	CLIP-seq
MIRT2465149	hsa-miR-4486	CLIP-seq
MIRT2510580	hsa-miR-4507	CLIP-seq
MIRT2510581	hsa-miR-4638-5p	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT2510582	hsa-miR-4714-3p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT2510583	hsa-miR-4735-5p	CLIP-seq
MIRT2510584	hsa-miR-4775	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT2510585	hsa-miR-4797-5p	CLIP-seq
MIRT2510586	hsa-miR-494	CLIP-seq
MIRT2510587	hsa-miR-501-3p	CLIP-seq
MIRT2510588	hsa-miR-502-3p	CLIP-seq
MIRT2510589	hsa-miR-5095	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT2510590	hsa-miR-519d	CLIP-seq
MIRT2510591	hsa-miR-520a-3p	CLIP-seq
MIRT2510592	hsa-miR-520b	CLIP-seq
MIRT2510593	hsa-miR-520c-3p	CLIP-seq
MIRT2510594	hsa-miR-520d-3p	CLIP-seq
MIRT2510595	hsa-miR-520e	CLIP-seq
MIRT2510596	hsa-miR-520f	CLIP-seq
MIRT2510597	hsa-miR-526b	CLIP-seq
MIRT2510598	hsa-miR-548a-3p	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2510599	hsa-miR-548e	CLIP-seq
MIRT2510600	hsa-miR-548f	CLIP-seq
MIRT2510601	hsa-miR-548o	CLIP-seq
MIRT2510602	hsa-miR-562	CLIP-seq
MIRT2510603	hsa-miR-578	CLIP-seq
MIRT2465152	hsa-miR-585	CLIP-seq
MIRT2510604	hsa-miR-590-3p	CLIP-seq
MIRT2510605	hsa-miR-635	CLIP-seq
MIRT2510606	hsa-miR-641	CLIP-seq
MIRT2510607	hsa-miR-642b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT2510608	hsa-miR-767-5p	CLIP-seq
MIRT2510609	hsa-miR-93	CLIP-seq
MIRT2510610	hsa-miR-944	CLIP-seq
MIRT2510555	hsa-miR-103b	CLIP-seq
MIRT2465143	hsa-miR-10a	CLIP-seq
MIRT2465144	hsa-miR-10b	CLIP-seq
MIRT916015	hsa-miR-1182	CLIP-seq
MIRT2678806	hsa-miR-1200	CLIP-seq
MIRT916016	hsa-miR-122	CLIP-seq
MIRT916017	hsa-miR-1299	CLIP-seq
MIRT2510559	hsa-miR-1323	CLIP-seq
MIRT916018	hsa-miR-193a-5p	CLIP-seq
MIRT916019	hsa-miR-214	CLIP-seq
MIRT916020	hsa-miR-3120-3p	CLIP-seq
MIRT916044	hsa-miR-3122	CLIP-seq
MIRT916021	hsa-miR-3135b	CLIP-seq
MIRT2510569	hsa-miR-3148	CLIP-seq
MIRT916022	hsa-miR-3182	CLIP-seq
MIRT916023	hsa-miR-3194-3p	CLIP-seq
MIRT2465147	hsa-miR-339-5p	CLIP-seq
MIRT2510570	hsa-miR-3613-3p	CLIP-seq
MIRT2510571	hsa-miR-3617	CLIP-seq
MIRT916024	hsa-miR-3619-5p	CLIP-seq
MIRT916025	hsa-miR-3650	CLIP-seq
MIRT916026	hsa-miR-3652	CLIP-seq
MIRT916027	hsa-miR-3664-5p	CLIP-seq
MIRT916052	hsa-miR-3689a-3p	CLIP-seq
MIRT916053	hsa-miR-3689c	CLIP-seq
MIRT2510572	hsa-miR-371-5p	CLIP-seq
MIRT2510573	hsa-miR-371b-5p	CLIP-seq
MIRT916054	hsa-miR-3913-5p	CLIP-seq
MIRT2510576	hsa-miR-3940-5p	CLIP-seq
MIRT916028	hsa-miR-431	CLIP-seq
MIRT2678807	hsa-miR-4324	CLIP-seq
MIRT2465148	hsa-miR-4421	CLIP-seq
MIRT916029	hsa-miR-4430	CLIP-seq
MIRT2510580	hsa-miR-4507	CLIP-seq
MIRT2678808	hsa-miR-450b-5p	CLIP-seq
MIRT916031	hsa-miR-4645-5p	CLIP-seq
MIRT916032	hsa-miR-4659a-3p	CLIP-seq
MIRT916033	hsa-miR-4659b-3p	CLIP-seq
MIRT916034	hsa-miR-4673	CLIP-seq
MIRT916070	hsa-miR-4695-3p	CLIP-seq
MIRT2510582	hsa-miR-4714-3p	CLIP-seq
MIRT916073	hsa-miR-4728-5p	CLIP-seq
MIRT916035	hsa-miR-4782-5p	CLIP-seq
MIRT2510585	hsa-miR-4797-5p	CLIP-seq
MIRT916078	hsa-miR-485-5p	CLIP-seq
MIRT2510586	hsa-miR-494	CLIP-seq
MIRT2465150	hsa-miR-511	CLIP-seq
MIRT916036	hsa-miR-516b	CLIP-seq
MIRT2678809	hsa-miR-518a-5p	CLIP-seq
MIRT2678810	hsa-miR-527	CLIP-seq
MIRT2510598	hsa-miR-548a-3p	CLIP-seq
MIRT2465151	hsa-miR-548c-3p	CLIP-seq
MIRT2510599	hsa-miR-548e	CLIP-seq
MIRT2510600	hsa-miR-548f	CLIP-seq
MIRT2510601	hsa-miR-548o	CLIP-seq
MIRT2510605	hsa-miR-635	CLIP-seq
MIRT2510606	hsa-miR-641	CLIP-seq
MIRT2510607	hsa-miR-642b	CLIP-seq
MIRT916037	hsa-miR-761	CLIP-seq
MIRT2510610	hsa-miR-944	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SPI1	Activation	16365419

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001968	Function	Fibronectin binding	IEA
GO:0001968	Function	Fibronectin binding	IPI	22952693
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002250	Process	Adaptive immune response	IEP	15196205
GO:0002577	Process	Regulation of antigen processing and presentation	IDA	22365146
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	8612130, 12788072, 22952693
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	1373132
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0005515	Function	Protein binding	IPI	15752368, 22365146
GO:0005518	Function	Collagen binding	IDA	22952693
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	9524075, 22952693
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IDA	15196205
GO:0005764	Component	Lysosome	IEA
GO:0005770	Component	Late endosome	IDA	22365146
GO:0006508	Process	Proteolysis	IDA	12788072, 22864553
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	1373132
GO:0006955	Process	Immune response	TAS	8157683
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IDA	15752368, 22365146
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0010447	Process	Response to acidic pH	IDA	22864553
GO:0016485	Process	Protein processing	IDA	22864553
GO:0016787	Function	Hydrolase activity	IEA
GO:0019882	Process	Antigen processing and presentation	TAS	15196205
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	30612035
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0022617	Process	Extracellular matrix disassembly	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030574	Process	Collagen catabolic process	IDA	22952693
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28344315
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034769	Process	Basement membrane disassembly	IDA	22952693
GO:0036021	Component	Endolysosome lumen	IEA
GO:0036021	Component	Endolysosome lumen	TAS
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043236	Function	Laminin binding	IDA	22952693
GO:0043394	Function	Proteoglycan binding	IEA
GO:0043394	Function	Proteoglycan binding	IPI	22952693
GO:0045335	Component	Phagocytic vesicle	IDA	30612035
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0048002	Process	Antigen processing and presentation of peptide antigen	IDA	8612130
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IDA	22952693
GO:0097067	Process	Cellular response to thyroid hormone stimulus	IEP	21217776
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:2001259	Process	Positive regulation of cation channel activity	IDA	22864553

Other IDs

• MIM: 116845
• HGNC: 2545
• e!Ensembl: ENSG00000163131

Protein

• UniProt ID: P25774
• Protein name: Cathepsin S (EC 3.4.22.27)
• Protein function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities
• PDB: 1GLO, 1MS6, 1NPZ, 1NQC, 2C0Y, 2F1G, 2FQ9, 2FRA, 2FRQ, 2FT2, 2FUD, 2FYE, 2G6D, 2G7Y, 2H7J, 2HH5, 2HHN, 2HXZ, 2OP3, 2R9M, 2R9N, 2R9O, 3IEJ, 3N3G, 3N4C, 3OVX, 4P6E, 4P6G, 5QBU, 5QBV, 5QBW, 5QBX, 5QBY, 5QBZ, 5QC0, 5QC1, 5QC2, 5QC3, 5QC4, 5QC5, 5QC6, 5QC7, 5QC8, 5QC9, 5QCA, 5QCB, 5QCC, 5QCD, 5QCE, 5QCF, 5QCG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08246	Inhibitor_I29	28 → 88	Cathepsin propeptide inhibitor domain (I29)	Domain
  PF00112	Peptidase_C1	115 → 330	Papain family cysteine protease	Domain

• Sequence:

  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
  LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
  WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
  NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
  AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
  GHNFGEEGYIRMARNKGNHCGIASFPSYPEI

• Sequence length: 331

Pathways

KEGG:

Lysosome
Phagosome
Apoptosis
Antigen processing and presentation
Tuberculosis

Reactome:

Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation