Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	151987
Gene name	Protein phosphatase 4 regulatory subunit 2
Gene symbol	PPP4R2
Synonyms (NCBI Gene)	PP4R2
Chromosome	3
Chromosome location	3p13
Summary	The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021467	hsa-miR-9-5p	Microarray	17612493
MIRT044944	hsa-miR-186-5p	CLASH	23622248
MIRT506060	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT506059	hsa-miR-567	HITS-CLIP	21572407
MIRT506057	hsa-miR-3924	HITS-CLIP	21572407
MIRT506056	hsa-miR-297	HITS-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT506059	hsa-miR-567	HITS-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT506057	hsa-miR-3924	HITS-CLIP	21572407
MIRT506056	hsa-miR-297	HITS-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614084	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT614083	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT614082	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT614081	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT614080	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT614079	hsa-miR-374c-5p	HITS-CLIP	23824327
MIRT614078	hsa-miR-655-3p	HITS-CLIP	23824327
MIRT506058	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614077	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT614076	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT506055	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT506059	hsa-miR-567	PAR-CLIP	20371350
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT506057	hsa-miR-3924	PAR-CLIP	20371350
MIRT506056	hsa-miR-297	PAR-CLIP	20371350
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT210746	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT210742	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT555300	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT555299	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506059	hsa-miR-567	PAR-CLIP	23446348
MIRT506057	hsa-miR-3924	PAR-CLIP	23446348
MIRT506056	hsa-miR-297	PAR-CLIP	23446348
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506059	hsa-miR-567	PAR-CLIP	23446348
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT506057	hsa-miR-3924	PAR-CLIP	23446348
MIRT506056	hsa-miR-297	PAR-CLIP	23446348
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT506060	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT506059	hsa-miR-567	HITS-CLIP	21572407
MIRT506057	hsa-miR-3924	HITS-CLIP	21572407
MIRT506056	hsa-miR-297	HITS-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT506059	hsa-miR-567	HITS-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT506057	hsa-miR-3924	HITS-CLIP	21572407
MIRT506056	hsa-miR-297	HITS-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT614084	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT614083	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT614082	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT614081	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT614080	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT614079	hsa-miR-374c-5p	HITS-CLIP	23824327
MIRT614078	hsa-miR-655-3p	HITS-CLIP	23824327
MIRT506058	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT614077	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT614076	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT506055	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT506059	hsa-miR-567	PAR-CLIP	20371350
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT506057	hsa-miR-3924	PAR-CLIP	20371350
MIRT506056	hsa-miR-297	PAR-CLIP	20371350
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT210746	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT210742	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT555300	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT555299	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT506059	hsa-miR-567	PAR-CLIP	21572407
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT506057	hsa-miR-3924	PAR-CLIP	21572407
MIRT506056	hsa-miR-297	PAR-CLIP	21572407
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506059	hsa-miR-567	PAR-CLIP	23446348
MIRT506057	hsa-miR-3924	PAR-CLIP	23446348
MIRT506056	hsa-miR-297	PAR-CLIP	23446348
MIRT506060	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506059	hsa-miR-567	PAR-CLIP	23446348
MIRT506058	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT506057	hsa-miR-3924	PAR-CLIP	23446348
MIRT506056	hsa-miR-297	PAR-CLIP	23446348
MIRT506055	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1258577	hsa-miR-200b	CLIP-seq
MIRT1258578	hsa-miR-200c	CLIP-seq
MIRT1258579	hsa-miR-217	CLIP-seq
MIRT1258580	hsa-miR-380	CLIP-seq
MIRT1258581	hsa-miR-429	CLIP-seq
MIRT1258582	hsa-miR-4418	CLIP-seq
MIRT1258583	hsa-miR-4495	CLIP-seq
MIRT1258584	hsa-miR-4799-5p	CLIP-seq
MIRT1258585	hsa-miR-509-3-5p	CLIP-seq
MIRT1258586	hsa-miR-509-5p	CLIP-seq
MIRT1258587	hsa-miR-548aa	CLIP-seq
MIRT1258577	hsa-miR-200b	CLIP-seq
MIRT1258578	hsa-miR-200c	CLIP-seq
MIRT1258579	hsa-miR-217	CLIP-seq
MIRT1258580	hsa-miR-380	CLIP-seq
MIRT1258581	hsa-miR-429	CLIP-seq
MIRT1258582	hsa-miR-4418	CLIP-seq
MIRT1258583	hsa-miR-4495	CLIP-seq
MIRT1258584	hsa-miR-4799-5p	CLIP-seq
MIRT1258585	hsa-miR-509-3-5p	CLIP-seq
MIRT1258586	hsa-miR-509-5p	CLIP-seq
MIRT1258587	hsa-miR-548aa	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	18614045
GO:0005515	Function	Protein binding	IPI	16085932, 18614045, 18715871, 19156129, 20154705, 26496610, 27880917, 28330616, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20154705
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	10769191
GO:0005856	Component	Cytoskeleton	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IMP	20154705
GO:0019888	Function	Protein phosphatase regulator activity	IBA
GO:0019888	Function	Protein phosphatase regulator activity	IEA
GO:0019888	Function	Protein phosphatase regulator activity	IMP	20154705
GO:0030289	Component	Protein phosphatase 4 complex	IBA
GO:0030289	Component	Protein phosphatase 4 complex	IDA	20154705
GO:0030289	Component	Protein phosphatase 4 complex	IEA
GO:0030289	Component	Protein phosphatase 4 complex	IPI	18614045
GO:0030674	Function	Protein-macromolecule adaptor activity	IMP	20154705
GO:0036211	Process	Protein modification process	TAS	10769191
GO:2000779	Process	Regulation of double-strand break repair	IMP	18614045

MIM	HGNC	e!Ensembl
613822	18296	ENSG00000163605

Q9NY27

Protein name

Serine/threonine-protein phosphatase 4 regulatory subunit 2

Protein function

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, sugg

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09184	PPP4R2	6 → 313	PPP4R2	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12668731}.

Sequence

MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDF
RTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDK
FLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRP
KVSLSAPMTTNGLPESTDSKEANLQQNEEKNHSDSSTSESEVSSVSPLKNKHPDEDAVEA
EGHEVKRLRFDKEGEVRETASQTTSSEISSVMVGETEASSSSQDKDKDSRCTRQHCTEED
EEEDEEEEEESFMTSREMIPERKNQEKESDDALTVNEETSEENNQMEESDVSQAEKDLLH
SEGSENEGPVSSSSSDCRETEELVGSNSSKTGEILSESSMENDDEATEVTDEPMEQD

Sequence length

417

Interactions

View interactions

	Reactome
			Processing of DNA double-strand break ends

PPP4R2 (protein phosphatase 4 regulatory subunit 2)