Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
151636
Gene name Gene Name - the full gene name approved by the HGNC.
Deltex E3 ubiquitin ligase 3L
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DTX3L
Synonyms (NCBI Gene) Gene synonyms aliases
BBAP, RNF143
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030687 hsa-miR-21-5p Microarray 18591254
MIRT681668 hsa-miR-5197-5p HITS-CLIP 23706177
MIRT681667 hsa-miR-6888-5p HITS-CLIP 23706177
MIRT681666 hsa-miR-6746-5p HITS-CLIP 23706177
MIRT681665 hsa-miR-7162-3p HITS-CLIP 23706177
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination TAS
GO:0002230 Process Positive regulation of defense response to virus by host IGI 26479788
GO:0004842 Function Ubiquitin-protein transferase activity IDA 19818714, 28525742
GO:0004842 Function Ubiquitin-protein transferase activity IMP 23230272, 24790097, 26479788
GO:0004857 Function Enzyme inhibitor activity IMP 24790097
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613143 30323 ENSG00000163840
Protein
UniProt ID Q8TDB6
Protein name E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
Protein function E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiqu
PDB 3PG6 , 8R79
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 560 599 Domain
PF18102 DTC 607 739 Deltex C-terminal domain Domain
Sequence
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSE
RAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQISSLTQSQAETPSGDMHQHE
GHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQD
IERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPL
PYFEYFKYICPDKINSIEKRFGVNIEIQESSPNMVCLDFTSSRSGDLEAARESFASEFQK
NTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEA
FVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILF
ESKDRQVDLSVHAYASFIDAFQHASCQLMREVLLLKSLGKERKHLHQTKFADDFRKRHPN
VHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASP
PLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQ
TSYGIQKGNQPEGSMVFTVSRDSLPGYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQR
TAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYG
YPDPSYLKRVKEELKAKGI
E
Sequence length 740
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Notch signaling pathway   Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Squamous Cell Stimulate 18618715
Inflammation Associate 16809771
Lymphoma Associate 16809771
Lymphoma Large B Cell Diffuse Associate 16809771, 25605023
Multiple Myeloma Associate 28653881
Neoplasms Associate 16809771, 38182103
Prostatic Neoplasms Associate 24886089
Squamous Cell Carcinoma of Head and Neck Associate 38182103
Systemic Inflammatory Response Syndrome Associate 16809771
Uterine Cervical Neoplasms Associate 18618715