Gene Gene information from NCBI Gene database.
Entrez ID 151636
Gene name Deltex E3 ubiquitin ligase 3L
Gene symbol DTX3L
Synonyms (NCBI Gene)
BBAPRNF143
Chromosome 3
Chromosome location 3q21.1
Summary DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
miRNA miRNA information provided by mirtarbase database.
1087
miRTarBase ID miRNA Experiments Reference
MIRT030687 hsa-miR-21-5p Microarray 18591254
MIRT681668 hsa-miR-5197-5p HITS-CLIP 23706177
MIRT681667 hsa-miR-6888-5p HITS-CLIP 23706177
MIRT681666 hsa-miR-6746-5p HITS-CLIP 23706177
MIRT681665 hsa-miR-7162-3p HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IMP 28525742
GO:0002230 Process Positive regulation of defense response to virus by host IGI 26479788
GO:0002376 Process Immune system process IEA
GO:0004842 Function Ubiquitin-protein transferase activity IDA 19818714, 28525742
GO:0004842 Function Ubiquitin-protein transferase activity IMP 23230272, 24790097
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613143 30323 ENSG00000163840
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TDB6
Protein name E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
Protein function E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiqu
PDB 3PG6 , 8R79
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 560 599 Domain
PF18102 DTC 607 739 Deltex C-terminal domain Domain
Sequence
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSE
RAAKERVLKKGEHQILVDEKPVPIFLVPTENSIKKNTRPQISSLTQSQAETPSGDMHQHE
GHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQD
IERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPL
PYFEYFKYICPDKINSIEKRFGVNIEIQESSPNMVCLDFTSSRSGDLEAARESFASEFQK
NTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEA
FVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILF
ESKDRQVDLSVHAYASFIDAFQHASCQLMREVLLLKSLGKERKHLHQTKFADDFRKRHPN
VHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASP
PLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQ
TSYGIQKGNQPEGSMVFTVSRDSLPGYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQR
TAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYG
YPDPSYLKRVKEELKAKGI
E
Sequence length 740
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Notch signaling pathway   Antigen processing: Ubiquitination & Proteasome degradation