UPP2 (uridine phosphorylase 2)

Gene

• Entrez ID: 151531
• Gene name: Uridine phosphorylase 2
• Gene symbol: UPP2
• Synonyms (NCBI Gene): UDRPASE2, UP2, UPASE2
• Chromosome: 2
• Chromosome location: 2q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052364	hsa-let-7a-5p	CLASH	23622248
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT1476432	hsa-miR-155	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT1476436	hsa-miR-136	CLIP-seq
MIRT1476437	hsa-miR-1913	CLIP-seq
MIRT1476438	hsa-miR-3074-5p	CLIP-seq
MIRT1476439	hsa-miR-3189-5p	CLIP-seq
MIRT1476440	hsa-miR-324-3p	CLIP-seq
MIRT1476441	hsa-miR-4722-3p	CLIP-seq
MIRT1476442	hsa-miR-4758-3p	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT2143536	hsa-miR-3163	CLIP-seq
MIRT2143537	hsa-miR-4517	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004850	Function	Uridine phosphorylase activity	IDA	12849978, 21855639
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005829	Component	Cytosol	NAS	11278417
GO:0005829	Component	Cytosol	TAS
GO:0006218	Process	Uridine catabolic process	IDA	12849978, 21855639
GO:0009116	Process	Nucleoside metabolic process	NAS	12849978
GO:0009166	Process	Nucleotide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	21855639, 25416956, 29892012, 31515488
GO:0043097	Process	Pyrimidine nucleoside salvage	TAS
GO:0044206	Process	UMP salvage	IEA
GO:0045098	Component	Type III intermediate filament	IDA	11278417
GO:0046108	Process	Uridine metabolic process	NAS	11278417
GO:0046135	Process	Pyrimidine nucleoside catabolic process	TAS

Other IDs

• MIM: 617340
• HGNC: 23061
• e!Ensembl: ENSG00000007001

Protein

• UniProt ID: O95045
• Protein name: Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)
• Protein function: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12849978, PubMed:21855639)
• PDB: 2XRF, 3P0E, 3P0F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01048	PNP_UDP_1	60 → 310	Phosphorylase superfamily	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in kidney. {ECO:0000269|PubMed:12849978}.
• Sequence:

  MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVK
  FVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPS
  ISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDN
  IVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD
  YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR
  PQLLISNFIRRRLGLCD

• Sequence length: 317

Pathways

KEGG:

Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Reactome:

Pyrimidine salvage
Pyrimidine catabolism

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	21151189

Unknown
Disease term	Disease name	Evidence	References	Source
Mental depression	Major Depressive Disorder		25897834	ClinVar
Diabetes	Diabetes			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Migraine Disorders	Associate	31842742