UPP2 (uridine phosphorylase 2)

Gene

• Entrez ID: 151531
• Gene name: Uridine phosphorylase 2
• Gene symbol: UPP2
• Synonyms (NCBI Gene): UDRPASE2, UP2, UPASE2
• Chromosome: 2
• Chromosome location: 2q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052364	hsa-let-7a-5p	CLASH	23622248
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT539579	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT539578	hsa-miR-26a-1-3p	PAR-CLIP	21572407
MIRT539577	hsa-miR-26a-2-3p	PAR-CLIP	21572407
MIRT539576	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT539575	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT1476432	hsa-miR-155	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT1476436	hsa-miR-136	CLIP-seq
MIRT1476437	hsa-miR-1913	CLIP-seq
MIRT1476438	hsa-miR-3074-5p	CLIP-seq
MIRT1476439	hsa-miR-3189-5p	CLIP-seq
MIRT1476440	hsa-miR-324-3p	CLIP-seq
MIRT1476441	hsa-miR-4722-3p	CLIP-seq
MIRT1476442	hsa-miR-4758-3p	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT1476433	hsa-miR-515-3p	CLIP-seq
MIRT1476434	hsa-miR-519e	CLIP-seq
MIRT1476435	hsa-miR-550a	CLIP-seq
MIRT2143536	hsa-miR-3163	CLIP-seq
MIRT2143537	hsa-miR-4517	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004850	Function	Uridine phosphorylase activity	IBA
GO:0004850	Function	Uridine phosphorylase activity	IDA	12849978, 21855639
GO:0004850	Function	Uridine phosphorylase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	NAS	11278417
GO:0005829	Component	Cytosol	TAS
GO:0006218	Process	Uridine catabolic process	IBA
GO:0006218	Process	Uridine catabolic process	IDA	12849978, 21855639
GO:0006218	Process	Uridine catabolic process	IEA
GO:0006248	Process	CMP catabolic process	IEA
GO:0006249	Process	DCMP catabolic process	IDA	12849978
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0009116	Process	Nucleoside metabolic process	NAS	12849978
GO:0009166	Process	Nucleotide catabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016763	Function	Pentosyltransferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	21855639, 25416956, 26871637, 29892012, 31515488, 32296183
GO:0044206	Process	UMP salvage	IEA
GO:0045098	Component	Type III intermediate filament	IDA	11278417
GO:0046050	Process	UMP catabolic process	IEA
GO:0046108	Process	Uridine metabolic process	NAS	11278417
GO:0047847	Function	Deoxyuridine phosphorylase activity	IDA	12849978
GO:0047847	Function	Deoxyuridine phosphorylase activity	IEA

Other IDs

• MIM: 617340
• HGNC: 23061
• e!Ensembl: ENSG00000007001

Protein

• UniProt ID: O95045
• Protein name: Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)
• Protein function: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12849978, PubMed:21855639)
• PDB: 2XRF, 3P0E, 3P0F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01048	PNP_UDP_1	60 → 310	Phosphorylase superfamily	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in kidney. {ECO:0000269|PubMed:12849978}.
• Sequence:

  MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVK
  FVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPS
  ISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDN
  IVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD
  YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR
  PQLLISNFIRRRLGLCD

• Sequence length: 317

Pathways

KEGG:

Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Reactome:

Pyrimidine salvage
Pyrimidine catabolism