Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	151449
Gene name	Growth differentiation factor 7
Gene symbol	GDF7
Synonyms (NCBI Gene)	BMP12
Chromosome	2
Chromosome location	2p24.1
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048114	hsa-miR-197-3p	CLASH	23622248
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT711488	hsa-miR-1207-3p	HITS-CLIP	19536157
MIRT711487	hsa-miR-3687	HITS-CLIP	19536157
MIRT711486	hsa-miR-4442	HITS-CLIP	19536157
MIRT711485	hsa-miR-3135b	HITS-CLIP	19536157
MIRT711484	hsa-miR-1289	HITS-CLIP	19536157
MIRT711483	hsa-miR-4294	HITS-CLIP	19536157
MIRT711482	hsa-miR-3198	HITS-CLIP	19536157
MIRT711481	hsa-miR-4309	HITS-CLIP	19536157
MIRT657900	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT657899	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT657898	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT657897	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT657896	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT657895	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT657894	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT657893	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT657892	hsa-miR-587	HITS-CLIP	23824327
MIRT657891	hsa-miR-3685	HITS-CLIP	23824327
MIRT657890	hsa-miR-384	HITS-CLIP	23824327
MIRT732843	hsa-miR-204-5p	Immunoprecipitaion (IP)Luciferase reporter assayqRT-PCR	33461605
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT719352	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT719353	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719351	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719350	hsa-miR-4736	HITS-CLIP	19536157
MIRT711488	hsa-miR-1207-3p	HITS-CLIP	19536157
MIRT711487	hsa-miR-3687	HITS-CLIP	19536157
MIRT711486	hsa-miR-4442	HITS-CLIP	19536157
MIRT711485	hsa-miR-3135b	HITS-CLIP	19536157
MIRT711484	hsa-miR-1289	HITS-CLIP	19536157
MIRT711483	hsa-miR-4294	HITS-CLIP	19536157
MIRT711482	hsa-miR-3198	HITS-CLIP	19536157
MIRT711481	hsa-miR-4309	HITS-CLIP	19536157
MIRT657900	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT657899	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT657898	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT657897	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT657896	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT657895	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT657894	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT657893	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT657892	hsa-miR-587	HITS-CLIP	23824327
MIRT657891	hsa-miR-3685	HITS-CLIP	23824327
MIRT657890	hsa-miR-384	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	16049014
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0021509	Process	Roof plate formation	IEA
GO:0021527	Process	Spinal cord association neuron differentiation	IEA
GO:0021915	Process	Neural tube development	IEA
GO:0022612	Process	Gland morphogenesis	IEA
GO:0030509	Process	BMP signaling pathway	IBA
GO:0030509	Process	BMP signaling pathway	IDA	16049014
GO:0030509	Process	BMP signaling pathway	IEA
GO:0030855	Process	Epithelial cell differentiation	IEA
GO:0030901	Process	Midbrain development	IEA
GO:0032924	Process	Activin receptor signaling pathway	IDA	16049014
GO:0042802	Function	Identical protein binding	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	16049014
GO:0048608	Process	Reproductive structure development	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	IEA
GO:0048853	Process	Forebrain morphogenesis	IEA
GO:0060391	Process	Positive regulation of SMAD protein signal transduction	IDA	16049014
GO:0060571	Process	Morphogenesis of an epithelial fold	IEA
GO:0090092	Process	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IEA
GO:2001051	Process	Positive regulation of tendon cell differentiation	IEA

MIM	HGNC	e!Ensembl
604651	4222	ENSG00000143869

Q7Z4P5

Protein name

Growth/differentiation factor 7 (GDF-7)

Protein function

May play an active role in the motor area of the primate neocortex.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00688	TGFb_propeptide	66 → 278	TGF-beta propeptide	Family
PF00019	TGF_beta	348 → 449	Transforming growth factor beta like domain	Domain

Sequence

MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSPGGGGGGGGGGRTLAQAAGAA
AVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRADT
ITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLL
LLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGP
VPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPL
PDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKE
LGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARL
SPISILYIDAANNVVYKQYEDMVVEACGCR

Sequence length

450

Interactions

View interactions

	KEGG
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Axon guidance Hippo signaling pathway

GDF7 (growth differentiation factor 7)