Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
151194
Gene name Gene Name - the full gene name approved by the HGNC.
Methyltransferase 21A, HSPA lysine
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
METTL21A
Synonyms (NCBI Gene) Gene synonyms aliases
FAM119A, HCA557b, HSPA-KMT
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT045232 hsa-miR-186-5p CLASH 23622248
MIRT720984 hsa-miR-6776-3p HITS-CLIP 19536157
MIRT720983 hsa-miR-6746-3p HITS-CLIP 19536157
MIRT720982 hsa-miR-1306-5p HITS-CLIP 19536157
MIRT720981 hsa-miR-4772-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21516116, 23921388, 25416956, 29892012, 31515488, 32296183
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IBA 21873635
GO:0006479 Process Protein methylation IDA 22948820, 23349634
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615257 30476 ENSG00000144401
Protein
UniProt ID Q8WXB1
Protein name Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A)
Protein function Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-
PDB 4LEC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10294 Methyltransf_16 25 190 Lysine methyltransferase Family
Sequence
Sequence length 218
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Protein methylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder), AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
24529757
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 24529757
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Depressive Disorder Major Associate 25755794
Wounds and Injuries Associate 25755794