CTRL (chymotrypsin like)

Gene

• Entrez ID: 1506
• Gene name: Chymotrypsin like
• Gene symbol: CTRL
• Synonyms (NCBI Gene): CTRL1
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1971489	hsa-miR-1321	CLIP-seq
MIRT1971490	hsa-miR-2861	CLIP-seq
MIRT1971491	hsa-miR-3925-3p	CLIP-seq
MIRT1971492	hsa-miR-4270	CLIP-seq
MIRT1971493	hsa-miR-4441	CLIP-seq
MIRT1971494	hsa-miR-4512	CLIP-seq
MIRT1971495	hsa-miR-4685-5p	CLIP-seq
MIRT1971496	hsa-miR-4721	CLIP-seq
MIRT1971497	hsa-miR-4728-5p	CLIP-seq
MIRT1971498	hsa-miR-4739	CLIP-seq
MIRT1971499	hsa-miR-4756-5p	CLIP-seq
MIRT1971500	hsa-miR-766	CLIP-seq
MIRT2207270	hsa-miR-1227	CLIP-seq
MIRT2207271	hsa-miR-1237	CLIP-seq
MIRT2207272	hsa-miR-3182	CLIP-seq
MIRT2207273	hsa-miR-4690-3p	CLIP-seq
MIRT2207274	hsa-miR-512-5p	CLIP-seq
MIRT2207275	hsa-miR-668	CLIP-seq
MIRT2207276	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	IDA	9065485
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0008236	Function	Serine-type peptidase activity	IDA	9065485
GO:0030163	Process	Protein catabolic process	IC	9065485

Other IDs

• MIM: 118888
• HGNC: 2524
• e!Ensembl: ENSG00000141086

Protein

• UniProt ID: P40313
• Protein name: Chymotrypsin-like protease CTRL-1 (EC 3.4.21.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	34 → 257	Trypsin	Domain

• Sequence:

  MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFC
  GGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTMNN
  DVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALP
  LVTVNQCRQYWGSSITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCN
  VRAPAVYTRVSKFSTWINQVIAYN

• Sequence length: 264

Pathways

KEGG:

Pancreatic secretion
Protein digestion and absorption

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24287731

Associations from Text Mining
Disease Name	Relationship Type	References
Hematologic Neoplasms	Associate	19671918, 25578495
Idiopathic Pulmonary Fibrosis	Associate	34524912
Leukemia Lymphocytic Chronic B Cell	Stimulate	18224667
Multiple Myeloma	Associate	19671918
Prostatic Neoplasms	Associate	25578495
Stomach Neoplasms	Associate	12616123