SIK1 (salt inducible kinase 1)

Gene
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
150094
Gene name Gene Name - the full gene name approved by the HGNC.
Salt inducible kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SIK1
Synonyms (NCBI Gene) Gene synonyms aliases
DEE30, MSK, SIK, SIK-1, SIK1B, SNF1LK
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transdu
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Show/Hide all(925)
miRTarBase ID miRNA Experiments Reference
MIRT028368 hsa-miR-32-5p Sequencing 20371350
MIRT052414 hsa-let-7a-5p CLASH 23622248
MIRT050012 hsa-miR-28-5p CLASH 23622248
MIRT612496 hsa-miR-4731-3p HITS-CLIP 23824327
MIRT612495 hsa-miR-4801 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Show/Hide all(58)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 14976552
GO:0000287 Function Magnesium ion binding IEA
GO:0000287 Function Magnesium ion binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
MIM HGNC e!Ensembl
605705 11142 ENSG00000142178
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
  KEGG  
  Glucagon signaling pathway  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Developmental And Epileptic Encephalopathy Developmental and epileptic encephalopathy, 30 rs786205159, rs786205160, rs786205161, rs786205163 N/A
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Eczema Eczema N/A N/A GWAS
Epilepsy generalized epilepsy N/A N/A GenCC
Hypertension Hypertension N/A N/A GWAS
Infantile Spasms infantile spasms N/A N/A GenCC
Show/Hide Text Mining Associations (31)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 31824497
Autistic Disorder Associate 25839329
Breast Neoplasms Associate 29216867, 31819138, 33545220, 37556419
Carcinogenesis Associate 33545220
Carcinoma Non Small Cell Lung Associate 27266881
Carcinoma Non Small Cell Lung Inhibit 37116165
Cardiomegaly Associate 32364532, 35203255
Cardiomyopathy Hypertrophic Associate 35203255
Developmental Disabilities Associate 27966542
Diabetes Mellitus Type 2 Associate 37556419