Gene Gene information from NCBI Gene database.
Entrez ID 150094
Gene name Salt inducible kinase 1
Gene symbol SIK1
Synonyms (NCBI Gene)
DEE30MSKSIKSIK-1SIK1BSNF1LK
Chromosome 21
Chromosome location 21q22.3
Summary This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transdu
miRNA miRNA information provided by mirtarbase database.
925
miRTarBase ID miRNA Experiments Reference
MIRT028368 hsa-miR-32-5p Sequencing 20371350
MIRT052414 hsa-let-7a-5p CLASH 23622248
MIRT050012 hsa-miR-28-5p CLASH 23622248
MIRT612496 hsa-miR-4731-3p HITS-CLIP 23824327
MIRT612495 hsa-miR-4801 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
58
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 14976552
GO:0000287 Function Magnesium ion binding IEA
GO:0000287 Function Magnesium ion binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605705 11142 ENSG00000142178
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Glucagon signaling pathway  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
965
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Developmental and epileptic encephalopathy, 30 Likely pathogenic; Pathogenic rs2516964679, rs786205159, rs786205160, rs786205161, rs786205163, rs2516965790 RCV002280233
RCV000170344
RCV000170345
RCV000170346
RCV000170348
RCV003990168
Global developmental delay Likely pathogenic rs1256783641 RCV001807537
Language disorder Likely pathogenic rs1256783641 RCV001807537
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign; Likely benign rs17004546, rs148529513 RCV005901811
RCV005910198
Adrenocortical carcinoma, hereditary Benign rs17004546 RCV005901812
Cervical cancer Benign rs17004546 RCV005901813
Colon adenocarcinoma Benign rs17004546 RCV005901810
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 31824497
Autistic Disorder Associate 25839329
Breast Neoplasms Associate 29216867, 31819138, 33545220, 37556419
Carcinogenesis Associate 33545220
Carcinoma Non Small Cell Lung Associate 27266881
Carcinoma Non Small Cell Lung Inhibit 37116165
Cardiomegaly Associate 32364532, 35203255
Cardiomyopathy Hypertrophic Associate 35203255
Developmental Disabilities Associate 27966542
Diabetes Mellitus Type 2 Associate 37556419