IGSF5 (immunoglobulin superfamily member 5)

Gene

• Entrez ID: 150084
• Gene name: Immunoglobulin superfamily member 5
• Gene symbol: IGSF5
• Synonyms (NCBI Gene): GSF5, JAM4
• Chromosome: 21
• Chromosome location: 21q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1062766	hsa-miR-1297	CLIP-seq
MIRT1062767	hsa-miR-2052	CLIP-seq
MIRT1062768	hsa-miR-2110	CLIP-seq
MIRT1062769	hsa-miR-219-2-3p	CLIP-seq
MIRT1062770	hsa-miR-26a	CLIP-seq
MIRT1062771	hsa-miR-26b	CLIP-seq
MIRT1062772	hsa-miR-2964a-3p	CLIP-seq
MIRT1062773	hsa-miR-302a	CLIP-seq
MIRT1062774	hsa-miR-302b	CLIP-seq
MIRT1062775	hsa-miR-302c	CLIP-seq
MIRT1062776	hsa-miR-302d	CLIP-seq
MIRT1062777	hsa-miR-302e	CLIP-seq
MIRT1062778	hsa-miR-3150a-3p	CLIP-seq
MIRT1062779	hsa-miR-3157-5p	CLIP-seq
MIRT1062780	hsa-miR-3676	CLIP-seq
MIRT1062781	hsa-miR-372	CLIP-seq
MIRT1062782	hsa-miR-373	CLIP-seq
MIRT1062783	hsa-miR-4271	CLIP-seq
MIRT1062784	hsa-miR-4277	CLIP-seq
MIRT1062785	hsa-miR-4452	CLIP-seq
MIRT1062786	hsa-miR-4453	CLIP-seq
MIRT1062787	hsa-miR-4465	CLIP-seq
MIRT1062788	hsa-miR-4480	CLIP-seq
MIRT1062789	hsa-miR-4502	CLIP-seq
MIRT1062790	hsa-miR-4538	CLIP-seq
MIRT1062791	hsa-miR-4633-3p	CLIP-seq
MIRT1062792	hsa-miR-4643	CLIP-seq
MIRT1062793	hsa-miR-466	CLIP-seq
MIRT1062794	hsa-miR-4691-3p	CLIP-seq
MIRT1062795	hsa-miR-4694-5p	CLIP-seq
MIRT1062796	hsa-miR-4725-3p	CLIP-seq
MIRT1062797	hsa-miR-4747-5p	CLIP-seq
MIRT1062798	hsa-miR-4762-3p	CLIP-seq
MIRT1062799	hsa-miR-4789-3p	CLIP-seq
MIRT1062800	hsa-miR-520a-3p	CLIP-seq
MIRT1062801	hsa-miR-520b	CLIP-seq
MIRT1062802	hsa-miR-520c-3p	CLIP-seq
MIRT1062803	hsa-miR-520d-3p	CLIP-seq
MIRT1062804	hsa-miR-520e	CLIP-seq
MIRT1062805	hsa-miR-548an	CLIP-seq
MIRT2014810	hsa-miR-365	CLIP-seq
MIRT2014811	hsa-miR-4641	CLIP-seq
MIRT2247116	hsa-miR-490-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0098609	Process	Cell-cell adhesion	IBA

Other IDs

• MIM: 610638
• HGNC: 5952
• e!Ensembl: ENSG00000183067

Protein

• UniProt ID: Q9NSI5
• Protein name: Immunoglobulin superfamily member 5 (IgSF5) (Junctional adhesion molecule 4) (JAM-4)
• Protein function: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may fun
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	39 → 140	Immunoglobulin I-set domain	Domain

• Sequence:

  MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNC
  TVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGN
  IRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGL
  LVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQD
  TGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCC
  CRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCE
  SSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV

• Sequence length: 407

Pathways

KEGG:

Tight junction
Epithelial cell signaling in Helicobacter pylori infection