Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
150
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenoceptor alpha 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADRA2A
Synonyms (NCBI Gene) Gene synonyms aliases
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, FPLD8, ZNF32
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FPLD8
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.2
Summary Summary of gene provided in NCBI Entrez Gene.
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029792 hsa-miR-26b-5p Microarray 19088304
MIRT769817 hsa-miR-106a CLIP-seq
MIRT769818 hsa-miR-106b CLIP-seq
MIRT769819 hsa-miR-1179 CLIP-seq
MIRT769820 hsa-miR-1207-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001819 Process Positive regulation of cytokine production IDA 17655843
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004938 Function Alpha2-adrenergic receptor activity IBA 21873635
GO:0004938 Function Alpha2-adrenergic receptor activity IDA 10948191
GO:0004938 Function Alpha2-adrenergic receptor activity ISS 1354394
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
104210 281 ENSG00000150594
Protein
UniProt ID P08913
Protein name Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
Protein function Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine
PDB 1HLL , 1HO9 , 1HOD , 1HOF , 6K42 , 6KUX , 6KUY , 7EJ0 , 7EJ8 , 7EJA , 7EJK , 7W6P , 7W7E , 9CBL , 9CBM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 50 426 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 465
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
  Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Epilepsy, Cryptogenic, Awakening Epilepsy rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)
17341653
Hypertension Hypertensive disease rs13306026 10694191
Partial lipodystrophy Familial partial lipodystrophy rs121909244, rs72551362, rs72551363, rs72551364, rs121909245, rs121909246, rs28928900, rs57520892, rs60864230, rs57920071, rs61282106, rs61214927, rs1567075176, rs1567075667, rs587776968
View all (12 more)
27376152
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
25163438, 19439247, 22940547, 17034020
Unknown
Disease term Disease name Evidence References Source
Cirrhosis Cirrhosis 20083574 ClinVar
Mental depression Mental Depression, Depressive disorder 18794646, 21859713, 16333651, 11425914 ClinVar
Lipodystrophy lipodystrophy, familial partial, type 8, lipodystrophy GenCC
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 36759514
Anxiety Associate 33915198
Asthma Associate 23148572
Attention Deficit and Disruptive Behavior Disorders Associate 25964505
Attention Deficit Disorder with Hyperactivity Associate 20146095, 20731965, 24978879, 25964505, 27091191, 32791971, 34573389
Behcet Syndrome Associate 39278467
Bipolar and Related Disorders Associate 39278467
Bipolar Disorder Associate 39278467
Blood Platelet Disorders Associate 20526338, 29865896
Body Weight Associate 34573389