Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
149603
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 187
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF187
Synonyms (NCBI Gene) Gene synonyms aliases
RACO-1, RACO1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029670 hsa-miR-26b-5p Microarray 19088304
MIRT048702 hsa-miR-99a-5p CLASH 23622248
MIRT047251 hsa-miR-181b-5p CLASH 23622248
MIRT040880 hsa-miR-18a-3p CLASH 23622248
MIRT711041 hsa-miR-181a-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IDA 20852630
GO:0005515 Function Protein binding IPI 20852630, 32296183
GO:0005634 Component Nucleus IDA 20852630
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613754 27146 ENSG00000168159
Protein
UniProt ID Q5TA31
Protein name E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187)
Protein function E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
PDB 7OW2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00097 zf-C3HC4 12 52 Zinc finger, C3HC4 type (RING finger) Domain
Sequence
MALPAGPAEAACALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRA
VEPGRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADAGPLCAACRMAAGPEPPEWE
PRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRA
FFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ
Sequence length 235
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Stimulate 35165289
Esophageal Neoplasms Associate 32896069
Esophageal Squamous Cell Carcinoma Associate 32896069
Neoplasm Metastasis Associate 31477177
Neoplasms Associate 31477177, 32896069
Ovarian Neoplasms Associate 32057463