CNIH3 (cornichon family AMPA receptor auxiliary protein 3)

Gene

• Entrez ID: 149111
• Gene name: Cornichon family AMPA receptor auxiliary protein 3
• Gene symbol: CNIH3
• Synonyms (NCBI Gene): CNIH-3
• Chromosome: 1
• Chromosome location: 1q42.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017447	hsa-miR-335-5p	Microarray	18185580
MIRT899697	hsa-miR-1207-3p	CLIP-seq
MIRT899698	hsa-miR-188-3p	CLIP-seq
MIRT899699	hsa-miR-1915	CLIP-seq
MIRT899700	hsa-miR-329	CLIP-seq
MIRT899701	hsa-miR-337-3p	CLIP-seq
MIRT899702	hsa-miR-338-3p	CLIP-seq
MIRT899703	hsa-miR-361-3p	CLIP-seq
MIRT899704	hsa-miR-362-3p	CLIP-seq
MIRT899705	hsa-miR-4528	CLIP-seq
MIRT899706	hsa-miR-4667-3p	CLIP-seq
MIRT899707	hsa-miR-4699-3p	CLIP-seq
MIRT899708	hsa-miR-4726-3p	CLIP-seq
MIRT899709	hsa-miR-4749-3p	CLIP-seq
MIRT899710	hsa-miR-572	CLIP-seq
MIRT899711	hsa-miR-605	CLIP-seq
MIRT899712	hsa-miR-616	CLIP-seq
MIRT899713	hsa-miR-766	CLIP-seq
MIRT899714	hsa-miR-873	CLIP-seq
MIRT737626	hsa-miR-150	CLIP-seq
MIRT737631	hsa-miR-1972	CLIP-seq
MIRT737622	hsa-miR-3921	CLIP-seq
MIRT737624	hsa-miR-4264	CLIP-seq
MIRT737630	hsa-miR-4650-5p	CLIP-seq
MIRT737621	hsa-miR-4653-5p	CLIP-seq
MIRT737628	hsa-miR-4713-5p	CLIP-seq
MIRT737629	hsa-miR-4757-5p	CLIP-seq
MIRT737625	hsa-miR-4797-3p	CLIP-seq
MIRT737627	hsa-miR-532-3p	CLIP-seq
MIRT737620	hsa-miR-593	CLIP-seq
MIRT737623	hsa-miR-622	CLIP-seq
MIRT2202630	hsa-miR-1322	CLIP-seq
MIRT2202631	hsa-miR-135a	CLIP-seq
MIRT2202632	hsa-miR-135b	CLIP-seq
MIRT2202633	hsa-miR-2278	CLIP-seq
MIRT2202634	hsa-miR-3187-3p	CLIP-seq
MIRT2202635	hsa-miR-3622b-5p	CLIP-seq
MIRT2202636	hsa-miR-3925-3p	CLIP-seq
MIRT2202637	hsa-miR-4253	CLIP-seq
MIRT2202638	hsa-miR-4529-5p	CLIP-seq
MIRT899706	hsa-miR-4667-3p	CLIP-seq
MIRT2202639	hsa-miR-4691-5p	CLIP-seq
MIRT2202640	hsa-miR-4704-3p	CLIP-seq
MIRT2202641	hsa-miR-4761-3p	CLIP-seq
MIRT2202642	hsa-miR-4797-5p	CLIP-seq
MIRT2386277	hsa-miR-1231	CLIP-seq
MIRT2386278	hsa-miR-3120-5p	CLIP-seq
MIRT2386279	hsa-miR-3160-3p	CLIP-seq
MIRT2386280	hsa-miR-3670	CLIP-seq
MIRT737622	hsa-miR-3921	CLIP-seq
MIRT2386281	hsa-miR-4303	CLIP-seq
MIRT2386282	hsa-miR-4487	CLIP-seq
MIRT737621	hsa-miR-4653-5p	CLIP-seq
MIRT2386283	hsa-miR-558	CLIP-seq
MIRT2386284	hsa-miR-626	CLIP-seq
MIRT2505566	hsa-miR-3591-3p	CLIP-seq
MIRT2505567	hsa-miR-3613-3p	CLIP-seq
MIRT2505568	hsa-miR-4684-3p	CLIP-seq
MIRT2505569	hsa-miR-518a-5p	CLIP-seq
MIRT2505570	hsa-miR-527	CLIP-seq
MIRT2505571	hsa-miR-586	CLIP-seq
MIRT2505572	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016247	Function	Channel regulator activity	IEA
GO:0030425	Component	Dendrite	IBA
GO:0032281	Component	AMPA glutamate receptor complex	IEA
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0035249	Process	Synaptic transmission, glutamatergic	IEA
GO:0042391	Process	Regulation of membrane potential	IEA
GO:0043198	Component	Dendritic shaft	IEA
GO:0043198	Component	Dendritic shaft	ISS
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099645	Process	Neurotransmitter receptor localization to postsynaptic specialization membrane	IEA
GO:2000311	Process	Regulation of AMPA receptor activity	IDA	20805473

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TBE1
• Protein name: Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3)
• Protein function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivatio
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03311	Cornichon	7 → 51	Cornichon protein	Family
  PF03311	Cornichon	50 → 151	Cornichon protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}.
• Sequence:

  MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQCNPVHARERLRNIERI
  CFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCPADSSELAYDPP
  VVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS

• Sequence length: 160

Pathways

Reactome:

COPII-mediated vesicle transport
Cargo concentration in the ER