Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	149111
Gene name Gene Name - the full gene name approved by the HGNC.	Cornichon family AMPA receptor auxiliary protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CNIH3
Synonyms (NCBI Gene) Gene synonyms aliases	CNIH-3
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q42.12

Show/Hide all(62)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017447	hsa-miR-335-5p	Microarray	18185580
MIRT899697	hsa-miR-1207-3p	CLIP-seq
MIRT899698	hsa-miR-188-3p	CLIP-seq
MIRT899699	hsa-miR-1915	CLIP-seq
MIRT899700	hsa-miR-329	CLIP-seq
MIRT899701	hsa-miR-337-3p	CLIP-seq
MIRT899702	hsa-miR-338-3p	CLIP-seq
MIRT899703	hsa-miR-361-3p	CLIP-seq
MIRT899704	hsa-miR-362-3p	CLIP-seq
MIRT899705	hsa-miR-4528	CLIP-seq
MIRT899706	hsa-miR-4667-3p	CLIP-seq
MIRT899707	hsa-miR-4699-3p	CLIP-seq
MIRT899708	hsa-miR-4726-3p	CLIP-seq
MIRT899709	hsa-miR-4749-3p	CLIP-seq
MIRT899710	hsa-miR-572	CLIP-seq
MIRT899711	hsa-miR-605	CLIP-seq
MIRT899712	hsa-miR-616	CLIP-seq
MIRT899713	hsa-miR-766	CLIP-seq
MIRT899714	hsa-miR-873	CLIP-seq
MIRT737626	hsa-miR-150	CLIP-seq
MIRT737631	hsa-miR-1972	CLIP-seq
MIRT737622	hsa-miR-3921	CLIP-seq
MIRT737624	hsa-miR-4264	CLIP-seq
MIRT737630	hsa-miR-4650-5p	CLIP-seq
MIRT737621	hsa-miR-4653-5p	CLIP-seq
MIRT737628	hsa-miR-4713-5p	CLIP-seq
MIRT737629	hsa-miR-4757-5p	CLIP-seq
MIRT737625	hsa-miR-4797-3p	CLIP-seq
MIRT737627	hsa-miR-532-3p	CLIP-seq
MIRT737620	hsa-miR-593	CLIP-seq
MIRT737623	hsa-miR-622	CLIP-seq
MIRT2202630	hsa-miR-1322	CLIP-seq
MIRT2202631	hsa-miR-135a	CLIP-seq
MIRT2202632	hsa-miR-135b	CLIP-seq
MIRT2202633	hsa-miR-2278	CLIP-seq
MIRT2202634	hsa-miR-3187-3p	CLIP-seq
MIRT2202635	hsa-miR-3622b-5p	CLIP-seq
MIRT2202636	hsa-miR-3925-3p	CLIP-seq
MIRT2202637	hsa-miR-4253	CLIP-seq
MIRT2202638	hsa-miR-4529-5p	CLIP-seq
MIRT899706	hsa-miR-4667-3p	CLIP-seq
MIRT2202639	hsa-miR-4691-5p	CLIP-seq
MIRT2202640	hsa-miR-4704-3p	CLIP-seq
MIRT2202641	hsa-miR-4761-3p	CLIP-seq
MIRT2202642	hsa-miR-4797-5p	CLIP-seq
MIRT2386277	hsa-miR-1231	CLIP-seq
MIRT2386278	hsa-miR-3120-5p	CLIP-seq
MIRT2386279	hsa-miR-3160-3p	CLIP-seq
MIRT2386280	hsa-miR-3670	CLIP-seq
MIRT737622	hsa-miR-3921	CLIP-seq
MIRT2386281	hsa-miR-4303	CLIP-seq
MIRT2386282	hsa-miR-4487	CLIP-seq
MIRT737621	hsa-miR-4653-5p	CLIP-seq
MIRT2386283	hsa-miR-558	CLIP-seq
MIRT2386284	hsa-miR-626	CLIP-seq
MIRT2505566	hsa-miR-3591-3p	CLIP-seq
MIRT2505567	hsa-miR-3613-3p	CLIP-seq
MIRT2505568	hsa-miR-4684-3p	CLIP-seq
MIRT2505569	hsa-miR-518a-5p	CLIP-seq
MIRT2505570	hsa-miR-527	CLIP-seq
MIRT2505571	hsa-miR-586	CLIP-seq
MIRT2505572	hsa-miR-607	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016247	Function	Channel regulator activity	IEA
GO:0030425	Component	Dendrite	IBA	21873635
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS
GO:0035249	Process	Synaptic transmission, glutamatergic	IEA
GO:0042391	Process	Regulation of membrane potential	IEA
GO:0043198	Component	Dendritic shaft	ISS
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0048208	Process	COPII vesicle coating	TAS
GO:2000311	Process	Regulation of AMPA receptor activity	IBA	21873635
GO:2000311	Process	Regulation of AMPA receptor activity	IDA	20805473

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q8TBE1

Protein name

Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3)

Protein function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivatio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03311	Cornichon	7 → 51	Cornichon protein	Family
PF03311	Cornichon	50 → 151	Cornichon protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}.

Sequence

MAFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFKSPIDQCNPVHARERLRNIERI
CFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCPADSSELAYDPP
VVMNADTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS

Sequence length

160

Interactions

View interactions

	Reactome
			COPII-mediated vesicle transport Cargo concentration in the ER

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	23103966

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	References	Source
Unknown
Endometriosis	Endometriosis		20864642	ClinVar
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	36230901
Carotid Body Tumor	Associate	30967136
Opioid Related Disorders	Associate	31081034

CNIH3 (cornichon family AMPA receptor auxiliary protein 3)