Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
149041
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger and CCCH-type domains 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RC3H1
Synonyms (NCBI Gene) Gene synonyms aliases
FHL6, IMDSHY, RNF198, ROQUIN
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3` UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing r
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT038022 hsa-miR-423-5p CLASH 23622248
MIRT037221 hsa-miR-877-5p CLASH 23622248
MIRT521417 hsa-miR-410-3p HITS-CLIP 21572407
MIRT521420 hsa-miR-374a-5p HITS-CLIP 21572407
MIRT521419 hsa-miR-374b-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IBA 21873635
GO:0000209 Process Protein polyubiquitination IDA 26489670
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA 21873635
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
GO:0000932 Component P-body ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609424 29434 ENSG00000135870
Protein
UniProt ID Q5TC82
Protein name Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)
Protein function Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs
PDB 3X1O , 4QIK , 4QIL , 4ULW , 4YWQ , 8RHS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13445 zf-RING_UBOX 14 55 RING-type zinc-finger Domain
PF18386 ROQ_II 271 326 Roquin II domain Domain
PF00642 zf-CCCH 414 440 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. {ECO:0000269|Ref.3}.
Sequence
MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTD
IELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVG
LNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLS
SNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKT
SIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAP
DQWSSLLYGDQSHKSHMQSIIDKLQT
PASFAQSVQELTIALQRTGDPANLNRLRPHLELL
ANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCR
DMKQRGGCPRGASCTFAHSQ
EELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDE
GAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLL
ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAA
PPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQ
QYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYP
VAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSP
TLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEM
MNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMA
PQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPS
AEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMI
SSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLT
LTFSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP
Sequence length 1133
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hemophagocytic Lymphohistiocytosis hemophagocytic lymphohistiocytosis, familial, 6 GenCC
Schizophrenia Schizophrenia GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Coronavirus Infections Associate 34176764
Infections Associate 34176764
Lymphoma Large B Cell Diffuse Associate 37623434
Lymphoma T Cell Associate 23825522