RC3H1 (ring finger and CCCH-type domains 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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149041 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Ring finger and CCCH-type domains 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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RC3H1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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FHL6, IMDSHY, RNF198, ROQUIN |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q25.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3` UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing r |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||
UniProt ID | Q5TC82 | ||||||||||||||||||||
Protein name | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | ||||||||||||||||||||
Protein function | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs | ||||||||||||||||||||
PDB | 3X1O , 4QIK , 4QIL , 4ULW , 4YWQ , 8RHS | ||||||||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. {ECO:0000269|Ref.3}. | ||||||||||||||||||||
Sequence |
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Sequence length | 1133 | ||||||||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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