CCN2 (cellular communication network factor 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1490
Gene name Gene Name - the full gene name approved by the HGNC.
Cellular communication network factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCN2
Synonyms (NCBI Gene) Gene synonyms aliases
CTGF, HCS24, IBP-8, IGFBP8, KMD, NOV2, SEMDLSL
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth fa
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT735783 hsa-miR-18a-5p Luciferase reporter assay, Western blotting, qRT-PCR 32656212
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(46)
GO ID Ontology Definition Evidence Reference
GO:0001502 Process Cartilage condensation IEA
GO:0001503 Process Ossification IEA
GO:0001525 Process Angiogenesis IEA
GO:0001649 Process Osteoblast differentiation IMP 39414788
GO:0001894 Process Tissue homeostasis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
121009 2500 ENSG00000118523
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P29279
Protein name CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
Protein function Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP 27 → 82 Insulin-like growth factor binding protein Domain
PF00093 VWC 103 → 166 von Willebrand factor type C domain Family
PF19035 TSP1_CCN 199 → 242 CCN3 Nov like TSP1 domain Domain
PF00007 Cys_knot 253 → 346 Cystine-knot domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. {ECO:0000269|PubMed:1756408}.
Sequence
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Apelin signaling pathway
Hippo signaling pathway 		  YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Spondyloenchondrodysplasia spondyloepimetaphyseal dysplasia N/A N/A GenCC
Show/Hide Text Mining Associations (267)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 27062921
Adenoma Associate 26749005
Airway Remodeling Associate 24828686
Albuminuria Associate 20522428
Aneurysm Inhibit 26539497
Arthritis Rheumatoid Associate 22006448, 26584911, 40281642
Asthma Stimulate 16204585
Asthma Associate 37312162
Atherosclerosis Associate 10400038, 10601320, 11278731, 12736251
Atrial Fibrillation Stimulate 28323847, 29483593, 30697920