Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1489
Gene name Gene Name - the full gene name approved by the HGNC.	Cardiotrophin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CTF1
Synonyms (NCBI Gene) Gene synonyms aliases	CT-1, CT1
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene.

Show/Hide all(99)

miRTarBase ID	miRNA	Experiments
MIRT914603	hsa-miR-1178	CLIP-seq
MIRT914604	hsa-miR-1273	CLIP-seq
MIRT914605	hsa-miR-1273f	CLIP-seq
MIRT914606	hsa-miR-1285	CLIP-seq
MIRT914607	hsa-miR-1324	CLIP-seq
MIRT914608	hsa-miR-143	CLIP-seq
MIRT914609	hsa-miR-2110	CLIP-seq
MIRT914610	hsa-miR-2114	CLIP-seq
MIRT914611	hsa-miR-2278	CLIP-seq
MIRT914612	hsa-miR-3150a-5p	CLIP-seq
MIRT914613	hsa-miR-3150b-5p	CLIP-seq
MIRT914614	hsa-miR-3166	CLIP-seq
MIRT914615	hsa-miR-3187-5p	CLIP-seq
MIRT914616	hsa-miR-3197	CLIP-seq
MIRT914617	hsa-miR-342-3p	CLIP-seq
MIRT914618	hsa-miR-3714	CLIP-seq
MIRT914619	hsa-miR-377	CLIP-seq
MIRT914620	hsa-miR-3918	CLIP-seq
MIRT914621	hsa-miR-4271	CLIP-seq
MIRT914622	hsa-miR-4468	CLIP-seq
MIRT914623	hsa-miR-4486	CLIP-seq
MIRT914624	hsa-miR-4643	CLIP-seq
MIRT914625	hsa-miR-4649-3p	CLIP-seq
MIRT914626	hsa-miR-4649-5p	CLIP-seq
MIRT914627	hsa-miR-466	CLIP-seq
MIRT914628	hsa-miR-4667-5p	CLIP-seq
MIRT914629	hsa-miR-4700-5p	CLIP-seq
MIRT914630	hsa-miR-4708-5p	CLIP-seq
MIRT914631	hsa-miR-4725-3p	CLIP-seq
MIRT914632	hsa-miR-4725-5p	CLIP-seq
MIRT914633	hsa-miR-4731-5p	CLIP-seq
MIRT914634	hsa-miR-4770	CLIP-seq
MIRT914635	hsa-miR-4789-3p	CLIP-seq
MIRT914636	hsa-miR-504	CLIP-seq
MIRT914637	hsa-miR-597	CLIP-seq
MIRT914638	hsa-miR-612	CLIP-seq
MIRT914639	hsa-miR-661	CLIP-seq
MIRT914640	hsa-miR-940	CLIP-seq
MIRT914641	hsa-miR-1225-3p	CLIP-seq
MIRT914642	hsa-miR-1233	CLIP-seq
MIRT914643	hsa-miR-1304	CLIP-seq
MIRT914607	hsa-miR-1324	CLIP-seq
MIRT914644	hsa-miR-1827	CLIP-seq
MIRT914645	hsa-miR-2277-3p	CLIP-seq
MIRT914646	hsa-miR-2467-5p	CLIP-seq
MIRT914647	hsa-miR-2682	CLIP-seq
MIRT914614	hsa-miR-3166	CLIP-seq
MIRT914648	hsa-miR-3188	CLIP-seq
MIRT914649	hsa-miR-3192	CLIP-seq
MIRT914650	hsa-miR-34a	CLIP-seq
MIRT914651	hsa-miR-34c-5p	CLIP-seq
MIRT914652	hsa-miR-3612	CLIP-seq
MIRT914653	hsa-miR-3689a-3p	CLIP-seq
MIRT914654	hsa-miR-3689c	CLIP-seq
MIRT914655	hsa-miR-3689d	CLIP-seq
MIRT914656	hsa-miR-3944-5p	CLIP-seq
MIRT914657	hsa-miR-3975	CLIP-seq
MIRT914658	hsa-miR-4459	CLIP-seq
MIRT914622	hsa-miR-4468	CLIP-seq
MIRT914659	hsa-miR-449a	CLIP-seq
MIRT914660	hsa-miR-449b	CLIP-seq
MIRT914661	hsa-miR-449c	CLIP-seq
MIRT914662	hsa-miR-4728-5p	CLIP-seq
MIRT914633	hsa-miR-4731-5p	CLIP-seq
MIRT914663	hsa-miR-485-5p	CLIP-seq
MIRT914664	hsa-miR-512-3p	CLIP-seq
MIRT914665	hsa-miR-650	CLIP-seq
MIRT914666	hsa-miR-665	CLIP-seq
MIRT1971354	hsa-miR-3130-3p	CLIP-seq
MIRT1971355	hsa-miR-4252	CLIP-seq
MIRT914639	hsa-miR-661	CLIP-seq
MIRT914641	hsa-miR-1225-3p	CLIP-seq
MIRT914642	hsa-miR-1233	CLIP-seq
MIRT914604	hsa-miR-1273	CLIP-seq
MIRT1971354	hsa-miR-3130-3p	CLIP-seq
MIRT1971355	hsa-miR-4252	CLIP-seq
MIRT914623	hsa-miR-4486	CLIP-seq
MIRT914626	hsa-miR-4649-5p	CLIP-seq
MIRT914639	hsa-miR-661	CLIP-seq
MIRT914606	hsa-miR-1285	CLIP-seq
MIRT914615	hsa-miR-3187-5p	CLIP-seq
MIRT914638	hsa-miR-612	CLIP-seq
MIRT914639	hsa-miR-661	CLIP-seq
MIRT914612	hsa-miR-3150a-5p	CLIP-seq
MIRT914613	hsa-miR-3150b-5p	CLIP-seq
MIRT2510188	hsa-miR-1283	CLIP-seq
MIRT914612	hsa-miR-3150a-5p	CLIP-seq
MIRT914613	hsa-miR-3150b-5p	CLIP-seq
MIRT2510189	hsa-miR-3613-3p	CLIP-seq
MIRT2510190	hsa-miR-4684-5p	CLIP-seq
MIRT2510188	hsa-miR-1283	CLIP-seq
MIRT914606	hsa-miR-1285	CLIP-seq
MIRT914612	hsa-miR-3150a-5p	CLIP-seq
MIRT914613	hsa-miR-3150b-5p	CLIP-seq
MIRT914615	hsa-miR-3187-5p	CLIP-seq
MIRT2510189	hsa-miR-3613-3p	CLIP-seq
MIRT2510190	hsa-miR-4684-5p	CLIP-seq
MIRT914638	hsa-miR-612	CLIP-seq
MIRT914639	hsa-miR-661	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005146	Function	Leukemia inhibitory factor receptor binding	TAS	8833032
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	7862649
GO:0005615	Component	Extracellular space	IEA
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IBA
GO:0007267	Process	Cell-cell signaling	TAS	7862649
GO:0007399	Process	Nervous system development	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007517	Process	Muscle organ development	TAS	7862649, 8833032
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	7862649
GO:0030182	Process	Neuron differentiation	TAS	7738033
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	21912637
GO:0048666	Process	Neuron development	IEA

MIM	HGNC	e!Ensembl
600435	2499	ENSG00000150281

Protein

UniProt ID

Q16619

Protein name

Cardiotrophin-1 (CT-1)

Protein function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes

Sequence

MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPS
FSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLR
RLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGL
YREWLSRTEGDLGQLLPGGSA

Sequence length

201

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
cardiomyopathy	Cardiomyopathy	N/A	N/A	ClinVar
Cardiomyopathy	Primary dilated cardiomyopathy	N/A	N/A	ClinVar
Dilated Cardiomyopathy	Dilated Cardiomyopathy, Dominant	N/A	N/A	ClinVar
Hypertrophic Cardiomyopathy	Primary familial hypertrophic cardiomyopathy	N/A	N/A	ClinVar
Hypertrophic cardiomyopathy	hypertrophic cardiomyopathy	N/A	N/A	ClinVar
Myoclonic Epilepsy	Juvenile myoclonic epilepsy	N/A	N/A	GWAS
Myopathy	dilated cardiomyopathy	N/A	N/A	GenCC
Psoriasis	Psoriasis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34301211
Atherosclerosis	Associate	18055523, 23935888
Brain Ischemia	Associate	25732979
Cardiomyopathy Hypertrophic	Stimulate	16920889
Diabetes Mellitus	Inhibit	25025664
Diabetes Mellitus Type 2	Associate	23776558
Drug Related Side Effects and Adverse Reactions	Inhibit	17970078
Essential Hypertension	Associate	33813485
Heart Failure	Stimulate	17885560
Heart Failure	Associate	23041742, 33813485
Heart Valve Diseases	Associate	25732979
Hypertension	Associate	17885560
Hypertrophy	Associate	33813485
Hypertrophy Left Ventricular	Associate	33813485
Idiopathic Pulmonary Fibrosis	Associate	37858084
Insulin Resistance	Associate	25025664
Migraine Disorders	Associate	33813485
Multiple Endocrine Neoplasia Type 2a	Associate	33813485
Neoplasms	Associate	23220842
Neuromuscular Diseases	Associate	23776558

CTF1 (cardiotrophin 1)