Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1488
Gene name	C-terminal binding protein 2
Gene symbol	CTBP2
Synonyms (NCBI Gene)	-
Chromosome	10
Chromosome location	10q26.13
Summary	This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding dom

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006173	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT006173	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT006173	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT023997	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT051934	hsa-let-7b-5p	CLASH	23622248
MIRT494149	hsa-miR-8485	HITS-CLIP	23313552
MIRT607058	hsa-miR-4328	HITS-CLIP	23313552
MIRT494149	hsa-miR-8485	HITS-CLIP	23313552
MIRT607058	hsa-miR-4328	HITS-CLIP	23313552
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT668862	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT668861	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT668860	hsa-miR-4257	HITS-CLIP	23824327
MIRT668858	hsa-miR-4539	HITS-CLIP	23824327
MIRT668859	hsa-miR-7112-3p	HITS-CLIP	23824327
MIRT668857	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	24906430
MIRT607058	hsa-miR-4328	HITS-CLIP	24906430
MIRT494149	hsa-miR-8485	HITS-CLIP	24906430
MIRT494149	hsa-miR-8485	HITS-CLIP	24906430
MIRT607058	hsa-miR-4328	HITS-CLIP	24906430
MIRT494149	hsa-miR-8485	PAR-CLIP	20371350
MIRT494149	hsa-miR-8485	PAR-CLIP	22012620
MIRT494149	hsa-miR-8485	PAR-CLIP	23592263
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT607058	hsa-miR-4328	HITS-CLIP	27418678
MIRT607058	hsa-miR-4328	HITS-CLIP	27418678
MIRT607058	hsa-miR-4328	HITS-CLIP	27418678
MIRT607058	hsa-miR-4328	HITS-CLIP	27418678
MIRT607058	hsa-miR-4328	HITS-CLIP	27418678
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	27418678
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	27418678
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	27418678
MIRT494149	hsa-miR-8485	HITS-CLIP	23313552
MIRT607058	hsa-miR-4328	HITS-CLIP	23313552
MIRT494149	hsa-miR-8485	HITS-CLIP	23313552
MIRT607058	hsa-miR-4328	HITS-CLIP	23313552
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT668862	hsa-miR-4724-5p	HITS-CLIP	23824327
MIRT668861	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT668860	hsa-miR-4257	HITS-CLIP	23824327
MIRT668858	hsa-miR-4539	HITS-CLIP	23824327
MIRT668859	hsa-miR-7112-3p	HITS-CLIP	23824327
MIRT668857	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT630509	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT630508	hsa-miR-4679	HITS-CLIP	23824327
MIRT630507	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	HITS-CLIP	23824327
MIRT607058	hsa-miR-4328	HITS-CLIP	23824327
MIRT611132	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT611131	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT611130	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT494149	hsa-miR-8485	PAR-CLIP	20371350
MIRT494149	hsa-miR-8485	PAR-CLIP	22012620
MIRT494149	hsa-miR-8485	PAR-CLIP	23592263
MIRT913765	hsa-miR-1245b-3p	CLIP-seq
MIRT913766	hsa-miR-2113	CLIP-seq
MIRT913767	hsa-miR-3148	CLIP-seq
MIRT913768	hsa-miR-548ae	CLIP-seq
MIRT913769	hsa-miR-548aj	CLIP-seq
MIRT913770	hsa-miR-548am	CLIP-seq
MIRT913771	hsa-miR-548x	CLIP-seq
MIRT913772	hsa-miR-758	CLIP-seq
MIRT913773	hsa-miR-101	CLIP-seq
MIRT913774	hsa-miR-1200	CLIP-seq
MIRT913775	hsa-miR-1206	CLIP-seq
MIRT913776	hsa-miR-144	CLIP-seq
MIRT913777	hsa-miR-2116	CLIP-seq
MIRT913778	hsa-miR-2278	CLIP-seq
MIRT913779	hsa-miR-3074-5p	CLIP-seq
MIRT913780	hsa-miR-3163	CLIP-seq
MIRT913781	hsa-miR-338-5p	CLIP-seq
MIRT913782	hsa-miR-3616-5p	CLIP-seq
MIRT913783	hsa-miR-3647-5p	CLIP-seq
MIRT913784	hsa-miR-3660	CLIP-seq
MIRT913785	hsa-miR-3674	CLIP-seq
MIRT913786	hsa-miR-370	CLIP-seq
MIRT913787	hsa-miR-375	CLIP-seq
MIRT913788	hsa-miR-376a	CLIP-seq
MIRT913789	hsa-miR-376b	CLIP-seq
MIRT913790	hsa-miR-4255	CLIP-seq
MIRT913791	hsa-miR-4324	CLIP-seq
MIRT913792	hsa-miR-4329	CLIP-seq
MIRT913793	hsa-miR-4436a	CLIP-seq
MIRT913794	hsa-miR-4526	CLIP-seq
MIRT913795	hsa-miR-4677-5p	CLIP-seq
MIRT913796	hsa-miR-4719	CLIP-seq
MIRT913797	hsa-miR-4732-5p	CLIP-seq
MIRT913798	hsa-miR-4795-5p	CLIP-seq
MIRT913799	hsa-miR-4796-3p	CLIP-seq
MIRT913800	hsa-miR-492	CLIP-seq
MIRT913801	hsa-miR-513b	CLIP-seq
MIRT913802	hsa-miR-544b	CLIP-seq
MIRT913803	hsa-miR-548an	CLIP-seq
MIRT913804	hsa-miR-548t	CLIP-seq
MIRT913805	hsa-miR-548u	CLIP-seq
MIRT913806	hsa-miR-568	CLIP-seq
MIRT913807	hsa-miR-573	CLIP-seq
MIRT913808	hsa-miR-578	CLIP-seq
MIRT913809	hsa-miR-609	CLIP-seq
MIRT913810	hsa-miR-629	CLIP-seq
MIRT913811	hsa-miR-643	CLIP-seq
MIRT1970984	hsa-miR-1208	CLIP-seq
MIRT1970985	hsa-miR-1294	CLIP-seq
MIRT1970986	hsa-miR-129-5p	CLIP-seq
MIRT1970987	hsa-miR-1302	CLIP-seq
MIRT1970988	hsa-miR-133a	CLIP-seq
MIRT1970989	hsa-miR-133b	CLIP-seq
MIRT1970990	hsa-miR-147	CLIP-seq
MIRT1970991	hsa-miR-3122	CLIP-seq
MIRT1970992	hsa-miR-3200-5p	CLIP-seq
MIRT1970993	hsa-miR-3665	CLIP-seq
MIRT1970994	hsa-miR-3682-5p	CLIP-seq
MIRT1970995	hsa-miR-374c	CLIP-seq
MIRT1970996	hsa-miR-3913-5p	CLIP-seq
MIRT1970997	hsa-miR-4281	CLIP-seq
MIRT1970998	hsa-miR-4298	CLIP-seq
MIRT1970999	hsa-miR-4316	CLIP-seq
MIRT1971000	hsa-miR-4420	CLIP-seq
MIRT1971001	hsa-miR-450b-5p	CLIP-seq
MIRT1971002	hsa-miR-4652-3p	CLIP-seq
MIRT1971003	hsa-miR-4682	CLIP-seq
MIRT1971004	hsa-miR-4724-3p	CLIP-seq
MIRT1971005	hsa-miR-4762-3p	CLIP-seq
MIRT1971006	hsa-miR-4765	CLIP-seq
MIRT1971007	hsa-miR-507	CLIP-seq
MIRT1971008	hsa-miR-5096	CLIP-seq
MIRT1971009	hsa-miR-557	CLIP-seq
MIRT1971010	hsa-miR-561	CLIP-seq
MIRT1971011	hsa-miR-581	CLIP-seq
MIRT1971012	hsa-miR-590-3p	CLIP-seq
MIRT1971013	hsa-miR-593	CLIP-seq
MIRT913811	hsa-miR-643	CLIP-seq
MIRT1971014	hsa-miR-655	CLIP-seq
MIRT1971015	hsa-miR-657	CLIP-seq
MIRT1970984	hsa-miR-1208	CLIP-seq
MIRT913765	hsa-miR-1245b-3p	CLIP-seq
MIRT1970988	hsa-miR-133a	CLIP-seq
MIRT1970989	hsa-miR-133b	CLIP-seq
MIRT2206735	hsa-miR-1911	CLIP-seq
MIRT2206736	hsa-miR-198	CLIP-seq
MIRT2206737	hsa-miR-200b	CLIP-seq
MIRT2206738	hsa-miR-200c	CLIP-seq
MIRT913777	hsa-miR-2116	CLIP-seq
MIRT2206739	hsa-miR-3120-3p	CLIP-seq
MIRT913780	hsa-miR-3163	CLIP-seq
MIRT2206740	hsa-miR-3197	CLIP-seq
MIRT1970992	hsa-miR-3200-5p	CLIP-seq
MIRT2206741	hsa-miR-3611	CLIP-seq
MIRT913782	hsa-miR-3616-5p	CLIP-seq
MIRT913783	hsa-miR-3647-5p	CLIP-seq
MIRT913784	hsa-miR-3660	CLIP-seq
MIRT1970994	hsa-miR-3682-5p	CLIP-seq
MIRT1970995	hsa-miR-374c	CLIP-seq
MIRT913790	hsa-miR-4255	CLIP-seq
MIRT1970997	hsa-miR-4281	CLIP-seq
MIRT2206742	hsa-miR-429	CLIP-seq
MIRT1971000	hsa-miR-4420	CLIP-seq
MIRT2206743	hsa-miR-4475	CLIP-seq
MIRT913794	hsa-miR-4526	CLIP-seq
MIRT2206744	hsa-miR-4668-3p	CLIP-seq
MIRT913795	hsa-miR-4677-5p	CLIP-seq
MIRT1971003	hsa-miR-4682	CLIP-seq
MIRT2206745	hsa-miR-4704-3p	CLIP-seq
MIRT913796	hsa-miR-4719	CLIP-seq
MIRT2206746	hsa-miR-4738-3p	CLIP-seq
MIRT1971005	hsa-miR-4762-3p	CLIP-seq
MIRT1971006	hsa-miR-4765	CLIP-seq
MIRT913798	hsa-miR-4795-5p	CLIP-seq
MIRT1971008	hsa-miR-5096	CLIP-seq
MIRT2206747	hsa-miR-520d-5p	CLIP-seq
MIRT2206748	hsa-miR-524-5p	CLIP-seq
MIRT1971010	hsa-miR-561	CLIP-seq
MIRT913806	hsa-miR-568	CLIP-seq
MIRT913807	hsa-miR-573	CLIP-seq
MIRT913808	hsa-miR-578	CLIP-seq
MIRT1971013	hsa-miR-593	CLIP-seq
MIRT913811	hsa-miR-643	CLIP-seq
MIRT1971014	hsa-miR-655	CLIP-seq
MIRT2206749	hsa-miR-935	CLIP-seq
MIRT2206750	hsa-miR-942	CLIP-seq
MIRT1971010	hsa-miR-561	CLIP-seq
MIRT2510060	hsa-miR-1	CLIP-seq
MIRT913765	hsa-miR-1245b-3p	CLIP-seq
MIRT2510061	hsa-miR-1284	CLIP-seq
MIRT1970987	hsa-miR-1302	CLIP-seq
MIRT2510062	hsa-miR-1322	CLIP-seq
MIRT2206735	hsa-miR-1911	CLIP-seq
MIRT2206736	hsa-miR-198	CLIP-seq
MIRT2510063	hsa-miR-206	CLIP-seq
MIRT913766	hsa-miR-2113	CLIP-seq
MIRT2510064	hsa-miR-300	CLIP-seq
MIRT1970991	hsa-miR-3122	CLIP-seq
MIRT913767	hsa-miR-3148	CLIP-seq
MIRT913780	hsa-miR-3163	CLIP-seq
MIRT2206741	hsa-miR-3611	CLIP-seq
MIRT1970994	hsa-miR-3682-5p	CLIP-seq
MIRT2510065	hsa-miR-3692	CLIP-seq
MIRT2510066	hsa-miR-371b-5p	CLIP-seq
MIRT1970995	hsa-miR-374c	CLIP-seq
MIRT2510067	hsa-miR-381	CLIP-seq
MIRT1970996	hsa-miR-3913-5p	CLIP-seq
MIRT2510068	hsa-miR-4251	CLIP-seq
MIRT1970998	hsa-miR-4298	CLIP-seq
MIRT2510069	hsa-miR-4436b-5p	CLIP-seq
MIRT2510070	hsa-miR-448	CLIP-seq
MIRT2510071	hsa-miR-4529-5p	CLIP-seq
MIRT2510072	hsa-miR-4635	CLIP-seq
MIRT1971002	hsa-miR-4652-3p	CLIP-seq
MIRT2510073	hsa-miR-4659a-3p	CLIP-seq
MIRT2510074	hsa-miR-4659b-3p	CLIP-seq
MIRT2510075	hsa-miR-4666-3p	CLIP-seq
MIRT2510076	hsa-miR-4698	CLIP-seq
MIRT2510077	hsa-miR-4717-5p	CLIP-seq
MIRT913796	hsa-miR-4719	CLIP-seq
MIRT2206746	hsa-miR-4738-3p	CLIP-seq
MIRT1971005	hsa-miR-4762-3p	CLIP-seq
MIRT2510078	hsa-miR-4778-3p	CLIP-seq
MIRT2206747	hsa-miR-520d-5p	CLIP-seq
MIRT2206748	hsa-miR-524-5p	CLIP-seq
MIRT2510079	hsa-miR-526b	CLIP-seq
MIRT2510080	hsa-miR-539	CLIP-seq
MIRT913768	hsa-miR-548ae	CLIP-seq
MIRT913769	hsa-miR-548aj	CLIP-seq
MIRT913770	hsa-miR-548am	CLIP-seq
MIRT913771	hsa-miR-548x	CLIP-seq
MIRT1971010	hsa-miR-561	CLIP-seq
MIRT1971012	hsa-miR-590-3p	CLIP-seq
MIRT2510081	hsa-miR-613	CLIP-seq
MIRT1971014	hsa-miR-655	CLIP-seq
MIRT913772	hsa-miR-758	CLIP-seq
MIRT913765	hsa-miR-1245b-3p	CLIP-seq
MIRT1970987	hsa-miR-1302	CLIP-seq
MIRT2206735	hsa-miR-1911	CLIP-seq
MIRT913766	hsa-miR-2113	CLIP-seq
MIRT2678731	hsa-miR-2467-3p	CLIP-seq
MIRT1970991	hsa-miR-3122	CLIP-seq
MIRT913767	hsa-miR-3148	CLIP-seq
MIRT913780	hsa-miR-3163	CLIP-seq
MIRT2206741	hsa-miR-3611	CLIP-seq
MIRT1970994	hsa-miR-3682-5p	CLIP-seq
MIRT2510065	hsa-miR-3692	CLIP-seq
MIRT1970996	hsa-miR-3913-5p	CLIP-seq
MIRT2510068	hsa-miR-4251	CLIP-seq
MIRT1970998	hsa-miR-4298	CLIP-seq
MIRT2510069	hsa-miR-4436b-5p	CLIP-seq
MIRT2510072	hsa-miR-4635	CLIP-seq
MIRT1971002	hsa-miR-4652-3p	CLIP-seq
MIRT2510073	hsa-miR-4659a-3p	CLIP-seq
MIRT2510074	hsa-miR-4659b-3p	CLIP-seq
MIRT2678732	hsa-miR-4707-3p	CLIP-seq
MIRT913796	hsa-miR-4719	CLIP-seq
MIRT2206746	hsa-miR-4738-3p	CLIP-seq
MIRT1971005	hsa-miR-4762-3p	CLIP-seq
MIRT2510078	hsa-miR-4778-3p	CLIP-seq
MIRT2678733	hsa-miR-4797-3p	CLIP-seq
MIRT2510079	hsa-miR-526b	CLIP-seq
MIRT2510080	hsa-miR-539	CLIP-seq
MIRT913768	hsa-miR-548ae	CLIP-seq
MIRT913769	hsa-miR-548aj	CLIP-seq
MIRT913770	hsa-miR-548am	CLIP-seq
MIRT913771	hsa-miR-548x	CLIP-seq
MIRT1971010	hsa-miR-561	CLIP-seq
MIRT1971012	hsa-miR-590-3p	CLIP-seq
MIRT913772	hsa-miR-758	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
HIPK2	Unknown	23393140

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	20705609
GO:0001221	Function	Transcription coregulator binding	IBA
GO:0001221	Function	Transcription coregulator binding	IEA
GO:0001222	Function	Transcription corepressor binding	IPI	29628311
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	20705609
GO:0005515	Function	Protein binding	IPI	16189514, 16702210, 19486893, 21516116, 21653829, 21903422, 21988832, 24722188, 25416956, 25728771, 25910212, 26496610, 26871637, 27107012, 27705803, 28947780, 31041561, 31515488, 32296183, 32814053, 33961781, 35016035, 35271311, 35800763, 36414381
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16702210
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9479502
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0017053	Component	Transcription repressor complex	ISS
GO:0019079	Process	Viral genome replication	TAS	9479502
GO:0019901	Function	Protein kinase binding	IPI	23393140
GO:0030154	Process	Cell differentiation	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0044877	Function	Protein-containing complex binding	IPI	23393140
GO:0045202	Component	Synapse	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	23775127
GO:0048386	Process	Positive regulation of retinoic acid receptor signaling pathway	IEA
GO:0048386	Process	Positive regulation of retinoic acid receptor signaling pathway	IMP	23775127
GO:0050872	Process	White fat cell differentiation	ISS
GO:0051287	Function	NAD binding	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IBA

MIM	HGNC	e!Ensembl
602619	2495	ENSG00000175029

P56545

Protein name

C-terminal-binding protein 2 (CtBP2)

Protein function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). ; Isoform 2 probably acts as a scaffold for specialized synapses.

PDB

2OME , 4LCJ , 6WKW , 8ATI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00389	2-Hacid_dh	36 → 358	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	Domain
PF02826	2-Hacid_dh_C	139 → 323	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Sequence

MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFC
DAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELG
IAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRG
ETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVS
LHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHES
EPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKE
FFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTV
AHPSQAPSPNQPTKHGDNREHPNEQ

Sequence length

445

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway Notch signaling pathway Pathways in cancer Chronic myeloid leukemia		Repression of WNT target genes TCF7L2 mutants don't bind CTBP

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Pulmonary artery atresia	Pathogenic	rs76203768, rs755416442, rs76079088	RCV002512180 RCV002512181 RCV003107980

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CTBP2-related disorder	Benign; Likely benign	rs2946994, rs3781412, rs142429792, rs3781411, rs3781409, rs3781408, rs3781413, rs112433109, rs3781410, rs12571821, rs185994757, rs73375140, rs201342709, rs7067816, rs3824796 View all (15 more)	RCV003974355 RCV003974377 RCV003904681 RCV003967374 RCV003979660 RCV003984612 RCV003984646 RCV003914199 RCV003916847 RCV003984472 RCV003939871 RCV003942084 RCV003917154 RCV003907302 RCV003914484 RCV003914511 RCV003924534 RCV003937203 RCV003934243 RCV003979112 RCV003981851 RCV003957276 RCV003971734 RCV003976291 RCV003976398 RCV003948320 RCV003950474 RCV003950475 RCV003912829 RCV003933133
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs74769610, rs1554881282	RCV004560212 RCV004560213
Gastric cancer	Likely benign	rs1554881282	RCV005927736

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Lung Injury	Associate	31754335
Adenocarcinoma of Lung	Stimulate	32756072
Adenoma	Associate	33972635
Alcoholism	Associate	28040410
Anorexia Nervosa	Associate	27184124
Arrhythmogenic Right Ventricular Dysplasia	Associate	29221435
Breast Neoplasms	Associate	23393140, 34074001
Carcinogenesis	Associate	30151388
Carcinogenesis	Inhibit	34878149
Carcinoma Hepatocellular	Stimulate	30151388
Carcinoma Non Small Cell Lung	Associate	37694353
Carcinoma Ovarian Epithelial	Associate	23730208, 32332713
Colorectal Neoplasms	Associate	25483087
Esophageal Squamous Cell Carcinoma	Associate	25820824, 29147064, 34878149
Glioma	Associate	28826173
Kidney Failure Chronic	Associate	31929749
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	27534394
Lung Neoplasms	Associate	37563730
Lymphatic Metastasis	Stimulate	25820824, 32756072
Metabolic Diseases	Associate	37286039
Neoplasm Metastasis	Associate	34878149
Neoplasms	Associate	20964627, 23393140, 24012420, 25483087, 25820824, 32756072, 34878149, 37563730
Neoplasms Squamous Cell	Stimulate	32993576
Neoplasms Squamous Cell	Associate	34878149
Obesity	Stimulate	27184124
Obesity	Associate	37286039
Ovarian Neoplasms	Associate	23730208
Ovarian Neoplasms	Stimulate	32332713
Prostatic Neoplasms	Associate	19318432, 21538423, 26773531, 31323811, 32215555
Renal Insufficiency Chronic	Associate	31929749
Spastic Paraplegia Hereditary	Associate	28040410
Uterine Cervical Dysplasia	Inhibit	32993576

CTBP2 (C-terminal binding protein 2)