ZNF558 (zinc finger protein 558)

Gene

• Entrez ID: 148156
• Gene name: Zinc finger protein 558
• Gene symbol: ZNF558
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017695	hsa-miR-335-5p	Microarray	18185580
MIRT025046	hsa-miR-181a-5p	Microarray	17612493
MIRT449064	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT449063	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT449062	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT449061	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT449060	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT449059	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449058	hsa-miR-555	PAR-CLIP	22100165
MIRT449064	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT449063	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT449062	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT449061	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT449060	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT449059	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449058	hsa-miR-555	PAR-CLIP	22100165
MIRT1529517	hsa-miR-1236	CLIP-seq
MIRT1529518	hsa-miR-141	CLIP-seq
MIRT1529519	hsa-miR-181a	CLIP-seq
MIRT1529520	hsa-miR-181b	CLIP-seq
MIRT1529521	hsa-miR-181c	CLIP-seq
MIRT1529522	hsa-miR-181d	CLIP-seq
MIRT1529523	hsa-miR-1827	CLIP-seq
MIRT1529524	hsa-miR-200a	CLIP-seq
MIRT1529525	hsa-miR-3155	CLIP-seq
MIRT1529526	hsa-miR-3155b	CLIP-seq
MIRT1529527	hsa-miR-384	CLIP-seq
MIRT1529528	hsa-miR-3920	CLIP-seq
MIRT1529529	hsa-miR-3929	CLIP-seq
MIRT1529530	hsa-miR-4262	CLIP-seq
MIRT1529531	hsa-miR-4419b	CLIP-seq
MIRT1529532	hsa-miR-4478	CLIP-seq
MIRT1529533	hsa-miR-4649-3p	CLIP-seq
MIRT1529534	hsa-miR-4709-3p	CLIP-seq
MIRT1529535	hsa-miR-4753-3p	CLIP-seq
MIRT1529536	hsa-miR-4768-5p	CLIP-seq
MIRT1529537	hsa-miR-484	CLIP-seq
MIRT1529538	hsa-miR-633	CLIP-seq
MIRT1529539	hsa-miR-759	CLIP-seq
MIRT2160068	hsa-miR-1257	CLIP-seq
MIRT2160069	hsa-miR-136	CLIP-seq
MIRT1529518	hsa-miR-141	CLIP-seq
MIRT1529519	hsa-miR-181a	CLIP-seq
MIRT1529520	hsa-miR-181b	CLIP-seq
MIRT1529521	hsa-miR-181c	CLIP-seq
MIRT1529522	hsa-miR-181d	CLIP-seq
MIRT1529524	hsa-miR-200a	CLIP-seq
MIRT2160070	hsa-miR-224	CLIP-seq
MIRT2160071	hsa-miR-3160-3p	CLIP-seq
MIRT2160072	hsa-miR-3160-5p	CLIP-seq
MIRT2160073	hsa-miR-3180-5p	CLIP-seq
MIRT2160074	hsa-miR-3591-5p	CLIP-seq
MIRT2160075	hsa-miR-3607-5p	CLIP-seq
MIRT1529527	hsa-miR-384	CLIP-seq
MIRT1529528	hsa-miR-3920	CLIP-seq
MIRT1529530	hsa-miR-4262	CLIP-seq
MIRT2160076	hsa-miR-4287	CLIP-seq
MIRT2160077	hsa-miR-4420	CLIP-seq
MIRT2160078	hsa-miR-4469	CLIP-seq
MIRT2160079	hsa-miR-4487	CLIP-seq
MIRT2160080	hsa-miR-4645-5p	CLIP-seq
MIRT2160081	hsa-miR-4673	CLIP-seq
MIRT2160082	hsa-miR-4685-3p	CLIP-seq
MIRT2160083	hsa-miR-4717-3p	CLIP-seq
MIRT2160084	hsa-miR-515-5p	CLIP-seq
MIRT2160085	hsa-miR-558	CLIP-seq
MIRT2160086	hsa-miR-648	CLIP-seq
MIRT2379429	hsa-miR-1237	CLIP-seq
MIRT2160068	hsa-miR-1257	CLIP-seq
MIRT2160069	hsa-miR-136	CLIP-seq
MIRT1529518	hsa-miR-141	CLIP-seq
MIRT1529519	hsa-miR-181a	CLIP-seq
MIRT1529520	hsa-miR-181b	CLIP-seq
MIRT1529521	hsa-miR-181c	CLIP-seq
MIRT1529522	hsa-miR-181d	CLIP-seq
MIRT1529523	hsa-miR-1827	CLIP-seq
MIRT1529524	hsa-miR-200a	CLIP-seq
MIRT2379430	hsa-miR-3136-5p	CLIP-seq
MIRT1529525	hsa-miR-3155	CLIP-seq
MIRT1529526	hsa-miR-3155b	CLIP-seq
MIRT2160073	hsa-miR-3180-5p	CLIP-seq
MIRT2160075	hsa-miR-3607-5p	CLIP-seq
MIRT2379431	hsa-miR-3647-3p	CLIP-seq
MIRT2379432	hsa-miR-371b-5p	CLIP-seq
MIRT2379433	hsa-miR-375	CLIP-seq
MIRT1529527	hsa-miR-384	CLIP-seq
MIRT1529528	hsa-miR-3920	CLIP-seq
MIRT1529529	hsa-miR-3929	CLIP-seq
MIRT1529530	hsa-miR-4262	CLIP-seq
MIRT1529531	hsa-miR-4419b	CLIP-seq
MIRT2160077	hsa-miR-4420	CLIP-seq
MIRT2379434	hsa-miR-4439	CLIP-seq
MIRT1529532	hsa-miR-4478	CLIP-seq
MIRT2379435	hsa-miR-4493	CLIP-seq
MIRT2379436	hsa-miR-4513	CLIP-seq
MIRT2160080	hsa-miR-4645-5p	CLIP-seq
MIRT1529533	hsa-miR-4649-3p	CLIP-seq
MIRT2160081	hsa-miR-4673	CLIP-seq
MIRT1529536	hsa-miR-4768-5p	CLIP-seq
MIRT2379437	hsa-miR-4786-5p	CLIP-seq
MIRT2379438	hsa-miR-4802-3p	CLIP-seq
MIRT1529537	hsa-miR-484	CLIP-seq
MIRT2379439	hsa-miR-493	CLIP-seq
MIRT2160084	hsa-miR-515-5p	CLIP-seq
MIRT2379440	hsa-miR-769-5p	CLIP-seq
MIRT2671425	hsa-miR-1178	CLIP-seq
MIRT1529517	hsa-miR-1236	CLIP-seq
MIRT2379429	hsa-miR-1237	CLIP-seq
MIRT2160068	hsa-miR-1257	CLIP-seq
MIRT2671426	hsa-miR-1297	CLIP-seq
MIRT2160069	hsa-miR-136	CLIP-seq
MIRT2671427	hsa-miR-139-5p	CLIP-seq
MIRT1529518	hsa-miR-141	CLIP-seq
MIRT2671428	hsa-miR-142-3p	CLIP-seq
MIRT1529519	hsa-miR-181a	CLIP-seq
MIRT1529520	hsa-miR-181b	CLIP-seq
MIRT1529521	hsa-miR-181c	CLIP-seq
MIRT1529522	hsa-miR-181d	CLIP-seq
MIRT1529524	hsa-miR-200a	CLIP-seq
MIRT2671429	hsa-miR-2117	CLIP-seq
MIRT2671430	hsa-miR-219-5p	CLIP-seq
MIRT2671431	hsa-miR-26a	CLIP-seq
MIRT2671432	hsa-miR-26b	CLIP-seq
MIRT2671433	hsa-miR-27a	CLIP-seq
MIRT2671434	hsa-miR-27b	CLIP-seq
MIRT2671435	hsa-miR-300	CLIP-seq
MIRT2671436	hsa-miR-3137	CLIP-seq
MIRT2160071	hsa-miR-3160-3p	CLIP-seq
MIRT2160072	hsa-miR-3160-5p	CLIP-seq
MIRT2160074	hsa-miR-3591-5p	CLIP-seq
MIRT2671437	hsa-miR-3614-3p	CLIP-seq
MIRT2671438	hsa-miR-3685	CLIP-seq
MIRT2671439	hsa-miR-370	CLIP-seq
MIRT2671440	hsa-miR-381	CLIP-seq
MIRT1529527	hsa-miR-384	CLIP-seq
MIRT2671441	hsa-miR-3910	CLIP-seq
MIRT2671442	hsa-miR-3913-3p	CLIP-seq
MIRT1529528	hsa-miR-3920	CLIP-seq
MIRT2671443	hsa-miR-4251	CLIP-seq
MIRT1529530	hsa-miR-4262	CLIP-seq
MIRT2160076	hsa-miR-4287	CLIP-seq
MIRT2671444	hsa-miR-4303	CLIP-seq
MIRT2671445	hsa-miR-4329	CLIP-seq
MIRT2160077	hsa-miR-4420	CLIP-seq
MIRT2671446	hsa-miR-4445	CLIP-seq
MIRT2671447	hsa-miR-4457	CLIP-seq
MIRT2671448	hsa-miR-4465	CLIP-seq
MIRT2160078	hsa-miR-4469	CLIP-seq
MIRT2671449	hsa-miR-4484	CLIP-seq
MIRT2160079	hsa-miR-4487	CLIP-seq
MIRT2379435	hsa-miR-4493	CLIP-seq
MIRT2671450	hsa-miR-4659a-3p	CLIP-seq
MIRT2671451	hsa-miR-4659b-3p	CLIP-seq
MIRT2671452	hsa-miR-4666-3p	CLIP-seq
MIRT2160082	hsa-miR-4685-3p	CLIP-seq
MIRT2671453	hsa-miR-4712-3p	CLIP-seq
MIRT2671454	hsa-miR-4713-5p	CLIP-seq
MIRT2160083	hsa-miR-4717-3p	CLIP-seq
MIRT1529535	hsa-miR-4753-3p	CLIP-seq
MIRT1529536	hsa-miR-4768-5p	CLIP-seq
MIRT2671455	hsa-miR-4778-3p	CLIP-seq
MIRT2671456	hsa-miR-4782-3p	CLIP-seq
MIRT2671457	hsa-miR-4786-3p	CLIP-seq
MIRT2379437	hsa-miR-4786-5p	CLIP-seq
MIRT2671458	hsa-miR-489	CLIP-seq
MIRT2671459	hsa-miR-495	CLIP-seq
MIRT2671460	hsa-miR-498	CLIP-seq
MIRT2671461	hsa-miR-508-3p	CLIP-seq
MIRT2671462	hsa-miR-513a-5p	CLIP-seq
MIRT2671463	hsa-miR-513b	CLIP-seq
MIRT2160084	hsa-miR-515-5p	CLIP-seq
MIRT2671464	hsa-miR-548an	CLIP-seq
MIRT2160085	hsa-miR-558	CLIP-seq
MIRT2671465	hsa-miR-606	CLIP-seq
MIRT2160086	hsa-miR-648	CLIP-seq
MIRT2671466	hsa-miR-668	CLIP-seq
MIRT2379440	hsa-miR-769-5p	CLIP-seq
MIRT1529517	hsa-miR-1236	CLIP-seq
MIRT2379429	hsa-miR-1237	CLIP-seq
MIRT2696124	hsa-miR-1285	CLIP-seq
MIRT2160069	hsa-miR-136	CLIP-seq
MIRT2671427	hsa-miR-139-5p	CLIP-seq
MIRT1529518	hsa-miR-141	CLIP-seq
MIRT1529519	hsa-miR-181a	CLIP-seq
MIRT1529520	hsa-miR-181b	CLIP-seq
MIRT1529521	hsa-miR-181c	CLIP-seq
MIRT1529522	hsa-miR-181d	CLIP-seq
MIRT1529524	hsa-miR-200a	CLIP-seq
MIRT2671433	hsa-miR-27a	CLIP-seq
MIRT2671434	hsa-miR-27b	CLIP-seq
MIRT2696125	hsa-miR-296-5p	CLIP-seq
MIRT2160071	hsa-miR-3160-3p	CLIP-seq
MIRT2160072	hsa-miR-3160-5p	CLIP-seq
MIRT2696126	hsa-miR-3182	CLIP-seq
MIRT2696127	hsa-miR-3187-5p	CLIP-seq
MIRT2160074	hsa-miR-3591-5p	CLIP-seq
MIRT2671437	hsa-miR-3614-3p	CLIP-seq
MIRT2671439	hsa-miR-370	CLIP-seq
MIRT2696128	hsa-miR-378g	CLIP-seq
MIRT1529527	hsa-miR-384	CLIP-seq
MIRT1529528	hsa-miR-3920	CLIP-seq
MIRT2671443	hsa-miR-4251	CLIP-seq
MIRT1529530	hsa-miR-4262	CLIP-seq
MIRT2696129	hsa-miR-4264	CLIP-seq
MIRT2160076	hsa-miR-4287	CLIP-seq
MIRT2671444	hsa-miR-4303	CLIP-seq
MIRT2696130	hsa-miR-4314	CLIP-seq
MIRT2696131	hsa-miR-4320	CLIP-seq
MIRT2671445	hsa-miR-4329	CLIP-seq
MIRT2160077	hsa-miR-4420	CLIP-seq
MIRT2160078	hsa-miR-4469	CLIP-seq
MIRT2696132	hsa-miR-4486	CLIP-seq
MIRT2160079	hsa-miR-4487	CLIP-seq
MIRT2379435	hsa-miR-4493	CLIP-seq
MIRT2160082	hsa-miR-4685-3p	CLIP-seq
MIRT2671454	hsa-miR-4713-5p	CLIP-seq
MIRT2160083	hsa-miR-4717-3p	CLIP-seq
MIRT1529535	hsa-miR-4753-3p	CLIP-seq
MIRT1529536	hsa-miR-4768-5p	CLIP-seq
MIRT2671455	hsa-miR-4778-3p	CLIP-seq
MIRT2671457	hsa-miR-4786-3p	CLIP-seq
MIRT2379437	hsa-miR-4786-5p	CLIP-seq
MIRT2696133	hsa-miR-4797-3p	CLIP-seq
MIRT2671462	hsa-miR-513a-5p	CLIP-seq
MIRT2160084	hsa-miR-515-5p	CLIP-seq
MIRT2160085	hsa-miR-558	CLIP-seq
MIRT2696134	hsa-miR-612	CLIP-seq
MIRT2160086	hsa-miR-648	CLIP-seq
MIRT2671466	hsa-miR-668	CLIP-seq
MIRT2379440	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96NG5
• Protein name: Zinc finger protein 558
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	42 → 83	KRAB box	Family
  PF00096	zf-C2H2	153 → 174	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	180 → 202	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	208 → 230	Zinc finger, C2H2 type	Domain
  PF13912	zf-C2H2_6	263 → 289		Domain
  PF00096	zf-C2H2	292 → 314	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	320 → 342	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	348 → 370	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	376 → 398	Zinc finger, C2H2 type	Domain

• Sequence:

  MAAVILPSTAAPSSLFPASQQKGHTQGGELVNELLTSWLRGLVTFEDVAVEFTQEEWALL
  DPAQRTLYRDVMLENCRNLASLGCRVNKPSLISQLEQDKKVVTEERGILPSTCPDLETLL
  KAKWLTPKKNVFRKEQSKGVKTERSHRGVKLNECNQCFKVFSTKSNLTQHKRIHTGEKPY
  DCSQCGKSFSSRSYLTIHKRIHNGEKPYECNHCGKAFSDPSSLRLHLRIHTGEKPYECNQ
  CFHVFRTSCNLKSHKRIHTGENHHECNQCGKAFSTRSSLTGHNSIHTGEKPYECHDCGKT
  FRKSSYLTQHVRTHTGEKPYECNECGKSFSSSFSLTVHKRIHTGEKPYECSDCGKAFNNL
  SAVKKHLRTHTGEKPYECNHCGKSFTSNSYLSVHKRIHNRWI

• Sequence length: 402

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations