Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	147923
Gene name	Zinc finger protein 420
Gene symbol	ZNF420
Synonyms (NCBI Gene)	APAK
Chromosome	19
Chromosome location	19q13.12
Summary	The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptos

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023175	hsa-miR-124-3p	Microarray	18668037
MIRT049236	hsa-miR-92a-3p	CLASH	23622248
MIRT042504	hsa-miR-423-3p	CLASH	23622248
MIRT1524282	hsa-miR-1255a	CLIP-seq
MIRT1524283	hsa-miR-1255b	CLIP-seq
MIRT1524284	hsa-miR-183	CLIP-seq
MIRT1524285	hsa-miR-3158-3p	CLIP-seq
MIRT1524286	hsa-miR-3200-5p	CLIP-seq
MIRT1524287	hsa-miR-342-3p	CLIP-seq
MIRT1524288	hsa-miR-3685	CLIP-seq
MIRT1524289	hsa-miR-371b-3p	CLIP-seq
MIRT1524290	hsa-miR-3908	CLIP-seq
MIRT1524291	hsa-miR-3942-5p	CLIP-seq
MIRT1524292	hsa-miR-4313	CLIP-seq
MIRT1524293	hsa-miR-4502	CLIP-seq
MIRT1524294	hsa-miR-4509	CLIP-seq
MIRT1524295	hsa-miR-4699-3p	CLIP-seq
MIRT1524296	hsa-miR-4703-5p	CLIP-seq
MIRT1524297	hsa-miR-4766-3p	CLIP-seq
MIRT1524298	hsa-miR-4768-5p	CLIP-seq
MIRT1524299	hsa-miR-516a-3p	CLIP-seq
MIRT1524300	hsa-miR-629	CLIP-seq
MIRT2377937	hsa-miR-145	CLIP-seq
MIRT2377938	hsa-miR-3180-5p	CLIP-seq
MIRT1524287	hsa-miR-342-3p	CLIP-seq
MIRT2377939	hsa-miR-3691-3p	CLIP-seq
MIRT1524289	hsa-miR-371b-3p	CLIP-seq
MIRT2377940	hsa-miR-4307	CLIP-seq
MIRT1524292	hsa-miR-4313	CLIP-seq
MIRT2377941	hsa-miR-432	CLIP-seq
MIRT2377942	hsa-miR-4464	CLIP-seq
MIRT2377943	hsa-miR-4712-5p	CLIP-seq
MIRT2377944	hsa-miR-4748	CLIP-seq
MIRT2377945	hsa-miR-4764-5p	CLIP-seq
MIRT2377946	hsa-miR-633	CLIP-seq
MIRT2377947	hsa-miR-770-5p	CLIP-seq
MIRT1524287	hsa-miR-342-3p	CLIP-seq
MIRT2670260	hsa-miR-1229	CLIP-seq
MIRT2670261	hsa-miR-1305	CLIP-seq
MIRT2670262	hsa-miR-135a	CLIP-seq
MIRT2670263	hsa-miR-135b	CLIP-seq
MIRT2670264	hsa-miR-181a	CLIP-seq
MIRT2670265	hsa-miR-181b	CLIP-seq
MIRT2670266	hsa-miR-181c	CLIP-seq
MIRT2670267	hsa-miR-181d	CLIP-seq
MIRT2670268	hsa-miR-1827	CLIP-seq
MIRT1524284	hsa-miR-183	CLIP-seq
MIRT2670269	hsa-miR-200b	CLIP-seq
MIRT2670270	hsa-miR-200c	CLIP-seq
MIRT2670271	hsa-miR-218	CLIP-seq
MIRT2670272	hsa-miR-2277-3p	CLIP-seq
MIRT2670273	hsa-miR-23a	CLIP-seq
MIRT2670274	hsa-miR-23b	CLIP-seq
MIRT2670275	hsa-miR-23c	CLIP-seq
MIRT2670276	hsa-miR-3117-5p	CLIP-seq
MIRT2670277	hsa-miR-3145-3p	CLIP-seq
MIRT1524285	hsa-miR-3158-3p	CLIP-seq
MIRT2670278	hsa-miR-3160-5p	CLIP-seq
MIRT1524286	hsa-miR-3200-5p	CLIP-seq
MIRT2670279	hsa-miR-325	CLIP-seq
MIRT2670280	hsa-miR-338-5p	CLIP-seq
MIRT1524287	hsa-miR-342-3p	CLIP-seq
MIRT1524288	hsa-miR-3685	CLIP-seq
MIRT2670281	hsa-miR-369-3p	CLIP-seq
MIRT1524289	hsa-miR-371b-3p	CLIP-seq
MIRT2670282	hsa-miR-3923	CLIP-seq
MIRT2670283	hsa-miR-410	CLIP-seq
MIRT2670284	hsa-miR-411	CLIP-seq
MIRT2670285	hsa-miR-4262	CLIP-seq
MIRT2670286	hsa-miR-429	CLIP-seq
MIRT1524293	hsa-miR-4502	CLIP-seq
MIRT1524294	hsa-miR-4509	CLIP-seq
MIRT2670287	hsa-miR-4528	CLIP-seq
MIRT2670288	hsa-miR-4662a-3p	CLIP-seq
MIRT2670289	hsa-miR-4732-5p	CLIP-seq
MIRT1524298	hsa-miR-4768-5p	CLIP-seq
MIRT2670290	hsa-miR-495	CLIP-seq
MIRT1524299	hsa-miR-516a-3p	CLIP-seq
MIRT2670291	hsa-miR-548ag	CLIP-seq
MIRT2670292	hsa-miR-548ai	CLIP-seq
MIRT2670293	hsa-miR-548m	CLIP-seq
MIRT2670294	hsa-miR-580	CLIP-seq
MIRT2670295	hsa-miR-600	CLIP-seq
MIRT2670296	hsa-miR-610	CLIP-seq
MIRT2670297	hsa-miR-636	CLIP-seq
MIRT2670298	hsa-miR-664	CLIP-seq
MIRT2670299	hsa-miR-758	CLIP-seq
MIRT2670300	hsa-miR-933	CLIP-seq
MIRT2670260	hsa-miR-1229	CLIP-seq
MIRT2670261	hsa-miR-1305	CLIP-seq
MIRT2670262	hsa-miR-135a	CLIP-seq
MIRT2670263	hsa-miR-135b	CLIP-seq
MIRT2670264	hsa-miR-181a	CLIP-seq
MIRT2670265	hsa-miR-181b	CLIP-seq
MIRT2670266	hsa-miR-181c	CLIP-seq
MIRT2670267	hsa-miR-181d	CLIP-seq
MIRT2670268	hsa-miR-1827	CLIP-seq
MIRT1524284	hsa-miR-183	CLIP-seq
MIRT2670271	hsa-miR-218	CLIP-seq
MIRT2670272	hsa-miR-2277-3p	CLIP-seq
MIRT2670273	hsa-miR-23a	CLIP-seq
MIRT2670274	hsa-miR-23b	CLIP-seq
MIRT2670275	hsa-miR-23c	CLIP-seq
MIRT2670276	hsa-miR-3117-5p	CLIP-seq
MIRT2670277	hsa-miR-3145-3p	CLIP-seq
MIRT1524285	hsa-miR-3158-3p	CLIP-seq
MIRT2670278	hsa-miR-3160-5p	CLIP-seq
MIRT1524286	hsa-miR-3200-5p	CLIP-seq
MIRT2670279	hsa-miR-325	CLIP-seq
MIRT1524287	hsa-miR-342-3p	CLIP-seq
MIRT2377939	hsa-miR-3691-3p	CLIP-seq
MIRT1524289	hsa-miR-371b-3p	CLIP-seq
MIRT2670282	hsa-miR-3923	CLIP-seq
MIRT2670283	hsa-miR-410	CLIP-seq
MIRT2670284	hsa-miR-411	CLIP-seq
MIRT2670285	hsa-miR-4262	CLIP-seq
MIRT1524292	hsa-miR-4313	CLIP-seq
MIRT2377941	hsa-miR-432	CLIP-seq
MIRT1524293	hsa-miR-4502	CLIP-seq
MIRT1524294	hsa-miR-4509	CLIP-seq
MIRT2670287	hsa-miR-4528	CLIP-seq
MIRT2670288	hsa-miR-4662a-3p	CLIP-seq
MIRT2670289	hsa-miR-4732-5p	CLIP-seq
MIRT1524298	hsa-miR-4768-5p	CLIP-seq
MIRT2670290	hsa-miR-495	CLIP-seq
MIRT2670294	hsa-miR-580	CLIP-seq
MIRT2670296	hsa-miR-610	CLIP-seq
MIRT2670297	hsa-miR-636	CLIP-seq
MIRT2670298	hsa-miR-664	CLIP-seq
MIRT2670299	hsa-miR-758	CLIP-seq
MIRT2670300	hsa-miR-933	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20713054, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
617216	20649	ENSG00000197050

Q8TAQ5

Protein name

Zinc finger protein 420

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	5 → 46	KRAB box	Family
PF00096	zf-C2H2	139 → 161	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	167 → 189	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	195 → 217	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	223 → 245	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	251 → 273	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	279 → 301	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	363 → 385	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	447 → 469	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	475 → 497	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	503 → 525	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	531 → 553	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	559 → 581	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	587 → 609	Zinc finger, C2H2 type	Domain
PF13465	zf-H2C2_2	629 → 654		Domain

Sequence

MARKLVMFRDVAIDFSQEEWECLDSAQRDLYRDVMLENYSNLVSLDLPSRCASKDLSPEK
NTYETELSQWEMSDRLENCDLEESNSRDYLEAKGKMEKQQENQKEYFRQGMIIYDKMSIF
NQHTYLSQHSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDS
QLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTR
HQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRI
HTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGE
KPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQLTQHQRIHTGEKPYQ
CKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKEC
GKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAF
ARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYECKECGKAFSHGS
QLTLHQRIHTGEKPYECRECRKAFTQSSHLSRHQRIHTGEKPYQCKECGKAFTRGSQLTQ
HQRIHISEKSFEYKECGIDFSHGSQVYM

Sequence length

688

Interactions

View interactions

	Reactome
			Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast ductal adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Hypoxia	Inhibit	25961932	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia Brain	Inhibit	25961932	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	20713054	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF420 (zinc finger protein 420)