Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	147906
Gene name Gene Name - the full gene name approved by the HGNC.	Dishevelled binding antagonist of beta catenin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DACT3
Synonyms (NCBI Gene) Gene synonyms aliases	DAPPER3, RRR1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.32

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005875	hsa-miR-31-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21048943
MIRT005875	hsa-miR-31-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21048943
MIRT005875	hsa-miR-31-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21048943
MIRT005875	hsa-miR-31-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21048943
MIRT005875	hsa-miR-31-5p	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21048943
MIRT731470	hsa-miR-638	Luciferase reporter assay, qRT-PCR, Western blot	28108314
MIRT731470	hsa-miR-638	Luciferase reporter assay, qRT-PCR, Western blot	28108314
MIRT731470	hsa-miR-638	Luciferase reporter assay, qRT-PCR, Western blot	28108314
MIRT731470	hsa-miR-638	Luciferase reporter assay, qRT-PCR, Western blot	28108314
MIRT756101	hsa-miR-9-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35598381
MIRT922683	hsa-miR-101	CLIP-seq
MIRT922684	hsa-miR-1183	CLIP-seq
MIRT922685	hsa-miR-1245b-3p	CLIP-seq
MIRT922686	hsa-miR-144	CLIP-seq
MIRT922687	hsa-miR-3121-5p	CLIP-seq
MIRT922688	hsa-miR-3126-3p	CLIP-seq
MIRT922689	hsa-miR-3150a-3p	CLIP-seq
MIRT922690	hsa-miR-3175	CLIP-seq
MIRT922691	hsa-miR-3176	CLIP-seq
MIRT922692	hsa-miR-3609	CLIP-seq
MIRT922693	hsa-miR-3915	CLIP-seq
MIRT922694	hsa-miR-3922-3p	CLIP-seq
MIRT922695	hsa-miR-3928	CLIP-seq
MIRT922696	hsa-miR-4667-5p	CLIP-seq
MIRT922697	hsa-miR-4700-5p	CLIP-seq
MIRT922698	hsa-miR-4775	CLIP-seq
MIRT922699	hsa-miR-4799-5p	CLIP-seq
MIRT922700	hsa-miR-495	CLIP-seq
MIRT922701	hsa-miR-548ah	CLIP-seq
MIRT922702	hsa-miR-590-3p	CLIP-seq
MIRT922703	hsa-miR-645	CLIP-seq
MIRT922704	hsa-miR-939	CLIP-seq
MIRT1973323	hsa-miR-1184	CLIP-seq
MIRT1973324	hsa-miR-1205	CLIP-seq
MIRT1973325	hsa-miR-1909	CLIP-seq
MIRT1973326	hsa-miR-3158-5p	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
EZH2	Repression	22144423
NKX2-5	Repression	19479054

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005080	Function	Protein kinase C binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IDA	18538736
GO:0030308	Process	Negative regulation of cell growth	IDA	18538736
GO:0042802	Function	Identical protein binding	IEA
GO:0051018	Function	Protein kinase A binding	ISS
GO:0070097	Function	Delta-catenin binding	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	18538736

MIM	HGNC	e!Ensembl
611112	30745	ENSG00000197380

Protein

UniProt ID

Q96B18

Protein name

Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3)

Protein function

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15268	Dapper	19 → 166	Dapper	Family
PF15268	Dapper	543 → 629	Dapper	Family

Sequence

MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDE
EDADEDEDAAAARRAAAALEEQLEALPGLVWDLGQQLGDLSLESGGLEQESGRSSGFYED
PSSTGGPDSPPSTFCGDSGFSGSSSYGRLGPSEPRGIYASERPKSLGDASPSAPEVVGAR
AAVPRSFSAPYPTAGGSAGPEACSSAERRARAGPFLTPSPLHAVAMRSPRPCGRPPTDSP
DAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGADGGPRRQNSVRQRPPDASPSPGSAR
PAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAAPSPPDSPAEGRLVKAQYI
PGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASGRRGSPRARK
ASRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGPAPTLAAQAAGSCRRWRSTA
EIDAADGRRVRPRAPAARVPGPGPSPSAPQRRLLYGCAGSDSECSAGRLGPLGRRGPAGG
VGGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAK
VFVKIKASHALKKKILRFRSGSLKVMTTV

Sequence length

629

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Lymphocytic Leukemia	Lymphocytic Leukemia			GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	35764883
Colorectal Neoplasms	Associate	18538736
Esophageal Neoplasms	Inhibit	28077137
Hypoxia	Stimulate	35764883
Inflammation	Associate	39341975
Leukemia Lymphocytic Chronic B Cell	Associate	22235315
Lung Neoplasms	Associate	21048943
Neoplasm Metastasis	Associate	35764883
Thyroid Cancer Papillary	Associate	21642358
Varicose Veins	Associate	39341975

DACT3 (dishevelled binding antagonist of beta catenin 3)