Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1479
Gene name Gene Name - the full gene name approved by the HGNC.	Cleavage stimulation factor subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CSTF3
Synonyms (NCBI Gene) Gene synonyms aliases	CSTF-77
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p13
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3` end cleavage of pre-mRNAs

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022875	hsa-miR-124-3p	Microarray	18668037
MIRT023876	hsa-miR-1-3p	Proteomics	18668040
MIRT030582	hsa-miR-24-3p	Microarray	19748357
MIRT045842	hsa-miR-132-3p	CLASH	23622248
MIRT043935	hsa-miR-378a-3p	CLASH	23622248
MIRT913599	hsa-miR-142-3p	CLIP-seq
MIRT913600	hsa-miR-298	CLIP-seq
MIRT913601	hsa-miR-3158-5p	CLIP-seq
MIRT913602	hsa-miR-4418	CLIP-seq
MIRT913603	hsa-miR-4420	CLIP-seq
MIRT913604	hsa-miR-509-3-5p	CLIP-seq
MIRT913605	hsa-miR-509-5p	CLIP-seq
MIRT913606	hsa-miR-648	CLIP-seq
MIRT913607	hsa-miR-3689a-5p	CLIP-seq
MIRT913608	hsa-miR-3689b	CLIP-seq
MIRT913609	hsa-miR-3689e	CLIP-seq
MIRT913610	hsa-miR-3689f	CLIP-seq
MIRT913611	hsa-miR-3942-3p	CLIP-seq
MIRT2510026	hsa-miR-3145-5p	CLIP-seq
MIRT2510027	hsa-miR-409-3p	CLIP-seq
MIRT2510028	hsa-miR-452	CLIP-seq
MIRT2510029	hsa-miR-4676-3p	CLIP-seq
MIRT2510030	hsa-miR-4684-3p	CLIP-seq
MIRT2510031	hsa-miR-4698	CLIP-seq
MIRT2510032	hsa-miR-4738-3p	CLIP-seq
MIRT2510033	hsa-miR-548g	CLIP-seq
MIRT2510034	hsa-miR-891b	CLIP-seq
MIRT2510026	hsa-miR-3145-5p	CLIP-seq
MIRT2678730	hsa-miR-3667-5p	CLIP-seq
MIRT2510027	hsa-miR-409-3p	CLIP-seq
MIRT2510028	hsa-miR-452	CLIP-seq
MIRT2510029	hsa-miR-4676-3p	CLIP-seq
MIRT2510030	hsa-miR-4684-3p	CLIP-seq
MIRT2510031	hsa-miR-4698	CLIP-seq
MIRT2510032	hsa-miR-4738-3p	CLIP-seq
MIRT2510033	hsa-miR-548g	CLIP-seq
MIRT2510034	hsa-miR-891b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7590244
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006369	Process	Termination of RNA polymerase II transcription	TAS
GO:0006378	Process	MRNA polyadenylation	TAS	7984242
GO:0006379	Process	MRNA cleavage	TAS	7984242
GO:0031123	Process	RNA 3'-end processing	IBA	21873635
GO:0031124	Process	MRNA 3'-end processing	TAS

MIM	HGNC	e!Ensembl
600367	2485	ENSG00000176102

Protein

UniProt ID

Q12996

Protein name

Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)

Protein function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

PDB

6B3X , 6URO , 7ZY4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05843	Suf	375 → 649	Suppressor of forked protein (Suf)	Family

Sequence

MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQ
FPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKE
KMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPM
INIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQ
NTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQY
LEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVH
SIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEY
YCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEK
SGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASE
LKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPP
GLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIIT
GGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR

Sequence length

717

Interactions

View interactions

	KEGG		Reactome
	mRNA surveillance pathway		mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	22491018

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Unipolar Depression, Major Depressive Disorder		27622933	ClinVar

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Colorectal Neoplasms	Associate	30243491
Neoplasms	Associate	27758885
Triple Negative Breast Neoplasms	Associate	27758885

CSTF3 (cleavage stimulation factor subunit 3)