CSTF1 (cleavage stimulation factor subunit 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 1477 |
| Gene name | Cleavage stimulation factor subunit 1 |
| Gene symbol | CSTF1 |
| Synonyms (NCBI Gene) |
CstF-50CstFp50
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| Chromosome | 20 |
| Chromosome location | 20q13.2-q13.31 |
| Summary | This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3`end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like |
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miRNA
miRNA information provided by mirtarbase database.
417
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q05048 | |||||||||||||||||||||||||||||||||||
| Protein name | Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) | |||||||||||||||||||||||||||||||||||
| Protein function | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729). | |||||||||||||||||||||||||||||||||||
| PDB | 6B3X | |||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 431 | |||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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