PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative))

Gene

• Entrez ID: 147699
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
• Gene symbol: PPM1N
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT615790	hsa-miR-4674	HITS-CLIP	23824327
MIRT615789	hsa-miR-1587	HITS-CLIP	23824327
MIRT615788	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT1254720	hsa-miR-129-5p	CLIP-seq
MIRT2075160	hsa-miR-3675-3p	CLIP-seq
MIRT2075161	hsa-miR-3919	CLIP-seq
MIRT2075162	hsa-miR-4330	CLIP-seq
MIRT2075163	hsa-miR-4661-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IEA
GO:0030145	Function	Manganese ion binding	IEA
GO:0043124	Process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N819
• Protein name: Probable protein phosphatase 1N (EC 3.1.3.16)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	65 → 319	Protein phosphatase 2C	Family
  PF07830	PP2C_C	320 → 397	Protein serine/threonine phosphatase 2C, C-terminal domain	Domain

• Sequence:

  MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEGPRSLLTAPRRAQRPHGGAE
  ASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPG
  HVLQELGPEPSEPEGVREALRRAFLSADERLRSLWPRVETGGCTAVVLLVSPRFLYLAHC
  GDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGDFTYKE
  APGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPE
  LLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAELCASAQK
  PPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQICQVSEECGEKGQDGAGKSNPT
  HLGSALDMEA

• Sequence length: 430

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Spondylometaphyseal dysplasia	SPASTIC PARAPLEGIA 12, AUTOSOMAL DOMINANT (disorder)	rs77975504, rs121912634, rs121912637, rs267607148, rs267607149, rs515726162, rs1599810980, rs769967246, rs786203989, rs1064795155, rs1553658926, rs1553659131, rs1181638652, rs1553667072, rs1553669703, rs140451304, rs1114167892, rs1114167893, rs778222701, rs1131690800, rs763623409, rs922930539, rs555164150, rs1555716575, rs1559604072, rs1559609410, rs1559616744, rs1596247721, rs1602071514