Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	147686
Gene name	Zinc finger protein 418
Gene symbol	ZNF418
Synonyms (NCBI Gene)	ZFP418
Chromosome	19
Chromosome location	19q13.43

113

Show/Hide all (113)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049908	hsa-miR-30a-3p	CLASH	23622248
MIRT443933	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT443932	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT443931	hsa-miR-3182	PAR-CLIP	22100165
MIRT443930	hsa-miR-5093	PAR-CLIP	22100165
MIRT443929	hsa-miR-3686	PAR-CLIP	22100165
MIRT443933	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT443932	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT443931	hsa-miR-3182	PAR-CLIP	22100165
MIRT443930	hsa-miR-5093	PAR-CLIP	22100165
MIRT443929	hsa-miR-3686	PAR-CLIP	22100165
MIRT443933	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT443932	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT443931	hsa-miR-3182	PAR-CLIP	22100165
MIRT443930	hsa-miR-5093	PAR-CLIP	22100165
MIRT443929	hsa-miR-3686	PAR-CLIP	22100165
MIRT443933	hsa-miR-651-3p	PAR-CLIP	22100165
MIRT443932	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT443931	hsa-miR-3182	PAR-CLIP	22100165
MIRT443930	hsa-miR-5093	PAR-CLIP	22100165
MIRT443929	hsa-miR-3686	PAR-CLIP	22100165
MIRT1524202	hsa-miR-1229	CLIP-seq
MIRT1524203	hsa-miR-1285	CLIP-seq
MIRT1524204	hsa-miR-1324	CLIP-seq
MIRT1524205	hsa-miR-181a	CLIP-seq
MIRT1524206	hsa-miR-181b	CLIP-seq
MIRT1524207	hsa-miR-181c	CLIP-seq
MIRT1524208	hsa-miR-181d	CLIP-seq
MIRT1524209	hsa-miR-23a	CLIP-seq
MIRT1524210	hsa-miR-23b	CLIP-seq
MIRT1524211	hsa-miR-23c	CLIP-seq
MIRT1524212	hsa-miR-2682	CLIP-seq
MIRT1524213	hsa-miR-298	CLIP-seq
MIRT1524214	hsa-miR-3160-3p	CLIP-seq
MIRT1524215	hsa-miR-3160-5p	CLIP-seq
MIRT1524216	hsa-miR-3166	CLIP-seq
MIRT1524217	hsa-miR-3187-5p	CLIP-seq
MIRT1524218	hsa-miR-335	CLIP-seq
MIRT1524219	hsa-miR-342-3p	CLIP-seq
MIRT1524220	hsa-miR-3612	CLIP-seq
MIRT1524221	hsa-miR-3689d	CLIP-seq
MIRT1524222	hsa-miR-421	CLIP-seq
MIRT1524223	hsa-miR-4254	CLIP-seq
MIRT1524224	hsa-miR-4262	CLIP-seq
MIRT1524225	hsa-miR-4272	CLIP-seq
MIRT1524226	hsa-miR-4423-3p	CLIP-seq
MIRT1524227	hsa-miR-4443	CLIP-seq
MIRT1524228	hsa-miR-4487	CLIP-seq
MIRT1524229	hsa-miR-449c	CLIP-seq
MIRT1524230	hsa-miR-4640-5p	CLIP-seq
MIRT1524231	hsa-miR-4699-3p	CLIP-seq
MIRT1524232	hsa-miR-4726-5p	CLIP-seq
MIRT1524233	hsa-miR-4789-3p	CLIP-seq
MIRT1524234	hsa-miR-485-5p	CLIP-seq
MIRT1524235	hsa-miR-558	CLIP-seq
MIRT1524236	hsa-miR-612	CLIP-seq
MIRT1524237	hsa-miR-617	CLIP-seq
MIRT1524238	hsa-miR-650	CLIP-seq
MIRT1524239	hsa-miR-660	CLIP-seq
MIRT1524240	hsa-miR-661	CLIP-seq
MIRT1524241	hsa-miR-940	CLIP-seq
MIRT1524203	hsa-miR-1285	CLIP-seq
MIRT2158422	hsa-miR-146a	CLIP-seq
MIRT2158423	hsa-miR-146b-5p	CLIP-seq
MIRT2158424	hsa-miR-1827	CLIP-seq
MIRT1524217	hsa-miR-3187-5p	CLIP-seq
MIRT1524220	hsa-miR-3612	CLIP-seq
MIRT1524221	hsa-miR-3689d	CLIP-seq
MIRT2158425	hsa-miR-3929	CLIP-seq
MIRT2158426	hsa-miR-4252	CLIP-seq
MIRT1524223	hsa-miR-4254	CLIP-seq
MIRT2158427	hsa-miR-4308	CLIP-seq
MIRT2158428	hsa-miR-4419b	CLIP-seq
MIRT1524227	hsa-miR-4443	CLIP-seq
MIRT2158429	hsa-miR-4478	CLIP-seq
MIRT2158430	hsa-miR-4649-3p	CLIP-seq
MIRT2158431	hsa-miR-4712-3p	CLIP-seq
MIRT2158432	hsa-miR-4722-5p	CLIP-seq
MIRT2158433	hsa-miR-4768-3p	CLIP-seq
MIRT1524234	hsa-miR-485-5p	CLIP-seq
MIRT2158434	hsa-miR-508-5p	CLIP-seq
MIRT2158435	hsa-miR-589	CLIP-seq
MIRT1524236	hsa-miR-612	CLIP-seq
MIRT1524238	hsa-miR-650	CLIP-seq
MIRT1524240	hsa-miR-661	CLIP-seq
MIRT2158436	hsa-miR-766	CLIP-seq
MIRT1524241	hsa-miR-940	CLIP-seq
MIRT2158424	hsa-miR-1827	CLIP-seq
MIRT1524220	hsa-miR-3612	CLIP-seq
MIRT1524221	hsa-miR-3689d	CLIP-seq
MIRT2158425	hsa-miR-3929	CLIP-seq
MIRT1524223	hsa-miR-4254	CLIP-seq
MIRT2158427	hsa-miR-4308	CLIP-seq
MIRT2158428	hsa-miR-4419b	CLIP-seq
MIRT1524227	hsa-miR-4443	CLIP-seq
MIRT2158429	hsa-miR-4478	CLIP-seq
MIRT2158430	hsa-miR-4649-3p	CLIP-seq
MIRT2158432	hsa-miR-4722-5p	CLIP-seq
MIRT2158433	hsa-miR-4768-3p	CLIP-seq
MIRT1524234	hsa-miR-485-5p	CLIP-seq
MIRT1524238	hsa-miR-650	CLIP-seq
MIRT2158436	hsa-miR-766	CLIP-seq
MIRT1524241	hsa-miR-940	CLIP-seq
MIRT2670252	hsa-miR-1273e	CLIP-seq
MIRT2670253	hsa-miR-1279	CLIP-seq
MIRT2670254	hsa-miR-374a	CLIP-seq
MIRT2670255	hsa-miR-374b	CLIP-seq
MIRT2670256	hsa-miR-3925-5p	CLIP-seq
MIRT2670257	hsa-miR-4277	CLIP-seq
MIRT2670258	hsa-miR-4311	CLIP-seq
MIRT2670259	hsa-miR-760	CLIP-seq
MIRT2670252	hsa-miR-1273e	CLIP-seq
MIRT2670259	hsa-miR-760	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001217	Function	DNA-binding transcription repressor activity	IDA	18084723
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18084723
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016237	Process	Microautophagy	ISS
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619509	20647	ENSG00000196724

Q8TF45

Protein name

Zinc finger protein 418

Protein function

Transcriptional repressor (PubMed:18084723). May play a role as regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	4 → 45	KRAB box	Family
PF00096	zf-C2H2	230 → 252	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	258 → 280	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	286 → 308	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	314 → 336	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	342 → 364	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	370 → 392	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	398 → 420	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	426 → 448	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	454 → 476	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	482 → 504	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	510 → 532	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	538 → 560	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	591 → 613	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	619 → 641	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	647 → 669	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart. {ECO:0000269|PubMed:18084723}.

Sequence

MQGTVAFEDVAVNFSQEEWSLLSEVQRCLYHDVMLENWVLISSLGCWCGSEDEEAPSKKS
ISIQRVSQVSTPGAGVSPKKAHSCEMCGAILGDILHLADHQGTHHKQKLHRCEAWGNKLY
DSSNRPHQNQYLGEKPYRSSVEEALFVKRCKFHVSEESSIFIQSGKDFLPSSGLLLQEAT
HTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVFVQQQRLPSREECYCWECGKSFS
KYDSVSNHQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGKRPYECGECGKSFSHKGS
LVQHQRVHTGERPYECGECGKSFSQNGTLIKHQRVHTGERPYECEECGKCFTQKGNLIQH
QRGHTSERPYECEECGKCFSQKGTLTEHHRVHTRERPYECGECGKSFSRKGHLRNHQRGH
TGERPYECGECGKSFSRKGNLIQHQRSHTGERPYECRECRKLFRGKSHLIEHQRVHTGER
PYECNECGKSFQDSSGFRVHQRVHTGEKPFECSECGKSFPQSCSLLRHRRVHTGERPYEC
GECGKSFHQSSSLLRHQKTHTAERPYECRECGKFFSSLLEHRRVHTGERPYECRECGKTF
TRRSAHFKHQRLHTRGKPYECSECGKSFAETFSLTEHRRVHTGERPYECSECGKSFHRSS
SLLRHQRVHTERSPYK

Sequence length

676

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Moyamoya angiopathy	Likely pathogenic	rs2072226563	RCV004704500	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Esophageal Squamous Cell Carcinoma	Associate	29270239	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	36547193	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF418 (zinc finger protein 418)