CST1 (cystatin SN)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1469
Gene name Gene Name - the full gene name approved by the HGNC.
Cystatin SN
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CST1
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p11.21
Summary Summary of gene provided in NCBI Entrez Gene.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT018277 hsa-miR-335-5p Microarray 18185580
MIRT913277 hsa-miR-3065-5p CLIP-seq
MIRT913278 hsa-miR-3173-5p CLIP-seq
MIRT913279 hsa-miR-339-3p CLIP-seq
MIRT913280 hsa-miR-370 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0001580 Process Detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0004869 Function Cysteine-type endopeptidase inhibitor activity IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005615 Component Extracellular space HDA 22664934, 23580065
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
123855 2473 ENSG00000170373
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01037
Protein name Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)
Protein function Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00031 Cystatin 32 → 127 Cystatin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}.
Sequence
Sequence length 141
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Salivary secretion  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 19463800
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 19208208
Show/Hide Text Mining Associations (39)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26683690
Adenocarcinoma of Lung Associate 35637432
Asthma Stimulate 28933920
Asthma Associate 31506971, 32460303, 35550122, 36354198, 36733482, 37241840, 37271320
Breast Neoplasms Stimulate 28523467
Breast Neoplasms Associate 31292488
Carcinogenesis Associate 35653624
Carcinoma Hepatocellular Associate 31115549
Carcinoma Non Small Cell Lung Associate 25648368, 35653624
Colorectal Neoplasms Associate 25577248, 28300829