Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	146059
Gene name	Codanin 1
Gene symbol	CDAN1
Synonyms (NCBI Gene)	CDA1CDAICDAN1ADLTPRO1295
Chromosome	15
Chromosome location	15q15.2
Summary	This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functiona

Show/Hide all (15)

SNP ID	Visualize variation	Clinical significance	Consequence
rs80338694	G>A,C	Likely-pathogenic, pathogenic	Coding sequence variant, upstream transcript variant, missense variant, genic upstream transcript variant, non coding transcript variant, synonymous variant
rs80338696	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs80338697	G>A,C,T	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant, genic downstream transcript variant, synonymous variant
rs80338699	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant, genic downstream transcript variant
rs113313967	C>T	Pathogenic	Intron variant
rs120074166	T>C	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs120074167	G>A	Likely-pathogenic, pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs120074168	A>T	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant, genic downstream transcript variant
rs120074169	AAC>-	Pathogenic	Non coding transcript variant, coding sequence variant, inframe deletion
rs138334226	G>A,C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs140334403	G>A,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs769679860	->A	Pathogenic	Genic downstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant
rs1223300626	->AA	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant, genic downstream transcript variant
rs1336651679	A>T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs1555414654	->GGC	Likely-pathogenic	Splice donor variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant

159

Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047385	hsa-miR-34a-5p	CLASH	23622248
MIRT037638	hsa-miR-744-5p	CLASH	23622248
MIRT876699	hsa-miR-106a	CLIP-seq
MIRT876700	hsa-miR-106b	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT876702	hsa-miR-1273f	CLIP-seq
MIRT876703	hsa-miR-17	CLIP-seq
MIRT876704	hsa-miR-1972	CLIP-seq
MIRT876705	hsa-miR-1976	CLIP-seq
MIRT876706	hsa-miR-20a	CLIP-seq
MIRT876707	hsa-miR-20b	CLIP-seq
MIRT876708	hsa-miR-2682	CLIP-seq
MIRT876709	hsa-miR-302a	CLIP-seq
MIRT876710	hsa-miR-302b	CLIP-seq
MIRT876711	hsa-miR-302c	CLIP-seq
MIRT876712	hsa-miR-302d	CLIP-seq
MIRT876713	hsa-miR-302e	CLIP-seq
MIRT876714	hsa-miR-3170	CLIP-seq
MIRT876715	hsa-miR-3187-3p	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT876718	hsa-miR-3663-5p	CLIP-seq
MIRT876719	hsa-miR-371-5p	CLIP-seq
MIRT876720	hsa-miR-371b-5p	CLIP-seq
MIRT876721	hsa-miR-372	CLIP-seq
MIRT876722	hsa-miR-373	CLIP-seq
MIRT876723	hsa-miR-3973	CLIP-seq
MIRT876724	hsa-miR-411	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT876726	hsa-miR-4324	CLIP-seq
MIRT876727	hsa-miR-4435	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT876729	hsa-miR-449c	CLIP-seq
MIRT876730	hsa-miR-4514	CLIP-seq
MIRT876731	hsa-miR-4635	CLIP-seq
MIRT876732	hsa-miR-4650-5p	CLIP-seq
MIRT876733	hsa-miR-4659a-5p	CLIP-seq
MIRT876734	hsa-miR-4659b-5p	CLIP-seq
MIRT876735	hsa-miR-4692	CLIP-seq
MIRT876736	hsa-miR-4701-5p	CLIP-seq
MIRT876737	hsa-miR-4708-5p	CLIP-seq
MIRT876738	hsa-miR-4716-5p	CLIP-seq
MIRT876739	hsa-miR-4722-3p	CLIP-seq
MIRT876740	hsa-miR-4731-5p	CLIP-seq
MIRT876741	hsa-miR-4742-5p	CLIP-seq
MIRT876742	hsa-miR-4755-3p	CLIP-seq
MIRT876743	hsa-miR-4757-5p	CLIP-seq
MIRT876744	hsa-miR-4776-3p	CLIP-seq
MIRT876745	hsa-miR-4781-3p	CLIP-seq
MIRT876746	hsa-miR-4793-5p	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876748	hsa-miR-512-3p	CLIP-seq
MIRT876749	hsa-miR-519d	CLIP-seq
MIRT876750	hsa-miR-520a-3p	CLIP-seq
MIRT876751	hsa-miR-520b	CLIP-seq
MIRT876752	hsa-miR-520c-3p	CLIP-seq
MIRT876753	hsa-miR-520d-3p	CLIP-seq
MIRT876754	hsa-miR-520e	CLIP-seq
MIRT876755	hsa-miR-520g	CLIP-seq
MIRT876756	hsa-miR-520h	CLIP-seq
MIRT876757	hsa-miR-544b	CLIP-seq
MIRT876758	hsa-miR-548p	CLIP-seq
MIRT876759	hsa-miR-548s	CLIP-seq
MIRT876760	hsa-miR-588	CLIP-seq
MIRT876761	hsa-miR-93	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT1959785	hsa-miR-1183	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT1959786	hsa-miR-133a	CLIP-seq
MIRT1959787	hsa-miR-133b	CLIP-seq
MIRT1959788	hsa-miR-146b-3p	CLIP-seq
MIRT1959789	hsa-miR-1914	CLIP-seq
MIRT1959790	hsa-miR-218	CLIP-seq
MIRT1959791	hsa-miR-3153	CLIP-seq
MIRT1959792	hsa-miR-3173-5p	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT1959793	hsa-miR-345	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT1959794	hsa-miR-365	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT1959795	hsa-miR-4281	CLIP-seq
MIRT876726	hsa-miR-4324	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT1959796	hsa-miR-4799-5p	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876757	hsa-miR-544b	CLIP-seq
MIRT1959797	hsa-miR-563	CLIP-seq
MIRT1959798	hsa-miR-627	CLIP-seq
MIRT1959799	hsa-miR-636	CLIP-seq
MIRT1959800	hsa-miR-874	CLIP-seq
MIRT1959801	hsa-miR-943	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT2196839	hsa-miR-122	CLIP-seq
MIRT876702	hsa-miR-1273f	CLIP-seq
MIRT2196840	hsa-miR-1912	CLIP-seq
MIRT876704	hsa-miR-1972	CLIP-seq
MIRT876705	hsa-miR-1976	CLIP-seq
MIRT2196841	hsa-miR-3130-5p	CLIP-seq
MIRT876714	hsa-miR-3170	CLIP-seq
MIRT876715	hsa-miR-3187-3p	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT876718	hsa-miR-3663-5p	CLIP-seq
MIRT876724	hsa-miR-411	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT876726	hsa-miR-4324	CLIP-seq
MIRT876727	hsa-miR-4435	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT2196842	hsa-miR-4452	CLIP-seq
MIRT2196843	hsa-miR-4463	CLIP-seq
MIRT2196844	hsa-miR-4466	CLIP-seq
MIRT2196845	hsa-miR-4482	CLIP-seq
MIRT2196846	hsa-miR-4494	CLIP-seq
MIRT876731	hsa-miR-4635	CLIP-seq
MIRT876732	hsa-miR-4650-5p	CLIP-seq
MIRT876733	hsa-miR-4659a-5p	CLIP-seq
MIRT876734	hsa-miR-4659b-5p	CLIP-seq
MIRT876736	hsa-miR-4701-5p	CLIP-seq
MIRT876738	hsa-miR-4716-5p	CLIP-seq
MIRT876739	hsa-miR-4722-3p	CLIP-seq
MIRT2196847	hsa-miR-4733-5p	CLIP-seq
MIRT876742	hsa-miR-4755-3p	CLIP-seq
MIRT876744	hsa-miR-4776-3p	CLIP-seq
MIRT876745	hsa-miR-4781-3p	CLIP-seq
MIRT876746	hsa-miR-4793-5p	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876757	hsa-miR-544b	CLIP-seq
MIRT876759	hsa-miR-548s	CLIP-seq
MIRT876760	hsa-miR-588	CLIP-seq
MIRT2196848	hsa-miR-675	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT876726	hsa-miR-4324	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT2500111	hsa-miR-4775	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876757	hsa-miR-544b	CLIP-seq
MIRT2500112	hsa-miR-590-3p	CLIP-seq
MIRT1959785	hsa-miR-1183	CLIP-seq
MIRT876701	hsa-miR-1200	CLIP-seq
MIRT2677799	hsa-miR-2278	CLIP-seq
MIRT876716	hsa-miR-329	CLIP-seq
MIRT1959793	hsa-miR-345	CLIP-seq
MIRT876717	hsa-miR-362-3p	CLIP-seq
MIRT876725	hsa-miR-4269	CLIP-seq
MIRT876726	hsa-miR-4324	CLIP-seq
MIRT876728	hsa-miR-4438	CLIP-seq
MIRT2677800	hsa-miR-498	CLIP-seq
MIRT876747	hsa-miR-5095	CLIP-seq
MIRT876757	hsa-miR-544b	CLIP-seq
MIRT1959801	hsa-miR-943	CLIP-seq

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Transcription factor	Regulation	Reference
E2F1	Unknown	19336738

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22407294
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21364188, 22407294
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	22407294
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006325	Process	Chromatin organization	IBA
GO:0006325	Process	Chromatin organization	IMP	21364188
GO:0006325	Process	Chromatin organization	IMP	22407294
GO:0008104	Process	Intracellular protein localization	IMP	21364188
GO:0012505	Component	Endomembrane system	IDA	21364188
GO:0016020	Component	Membrane	IEA
GO:0051170	Process	Import into nucleus	IMP	22407294

MIM	HGNC	e!Ensembl
607465	1713	ENSG00000140326

Q8IWY9

Protein name

Codanin-1

Protein function

May act as a negative regulator of ASF1 in chromatin assembly.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15296	Codanin-1_C	784 → 899	Codanin-1 C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 3 is not found in erythroid cells. {ECO:0000269|PubMed:12434312}.

Sequence

MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQ
SSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGG
RRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPP
VGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGL
PPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLPSRTGSLTDEPADPARVSSRQ
RLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPAVLDSLESPLF
QSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKV
SLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKG
LGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLG
RLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNG
LALPQHEPNDEDGESDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQ
DSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLL
LRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAP
EHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPS
QTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQ
LVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSS
AENIAVGLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHH
APLPSHLISEIKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAK
CSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNV
GLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFL
AEPHLPEPQLRACELVQPNRGTVLAQS

Sequence length

1227

Interactions

View interactions

493

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Anemia, congenital dyserythropoietic, type 1a	Pathogenic; Likely pathogenic	rs375339408, rs778822407, rs2140471687, rs2140505826, rs2506101144, rs80338697, rs80338699, rs120074166, rs120074167, rs2506131342, rs2506067560, rs778173860, rs2506137543, rs2506092231, rs1383200463, rs80338694, rs80338696, rs1336651679 View all (3 more)	RCV005009585 RCV003764481 RCV001780464 RCV001780465 RCV002280806 RCV001544511 RCV001839408 RCV005007811 RCV002466391 RCV003141256 RCV003335886 RCV003337798 RCV003493225 RCV003493226 RCV003764482 RCV001807737 RCV004795934 RCV001839414
CDAN1-related disorder	Likely pathogenic; Pathogenic	rs80338694	RCV004755746
Congenital dyserythropoietic anemia, type I	Likely pathogenic; Pathogenic	rs80338697, rs80338699, rs120074166, rs120074167, rs120074168, rs120074169, rs80338694, rs80338696, rs140334403	RCV000020956 RCV000020959 RCV000003328 RCV000020953 RCV000003330 RCV000003332 RCV004700262 RCV000020954 RCV000995713
Uterine corpus endometrial carcinoma	Pathogenic	rs145148854	RCV005927014

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Uncertain significance; Conflicting classifications of pathogenicity; Benign	rs201401533, rs200767055, rs114208791	RCV005934749 RCV005893362 RCV005893364
Adrenocortical carcinoma, hereditary	Benign; Likely benign	rs147500837	RCV005893370
Cervical cancer	Benign; Uncertain significance	rs16957109, rs113313967	RCV005915554 RCV005887240
Clear cell carcinoma of kidney	Conflicting classifications of pathogenicity; Benign; Likely benign	rs200767055, rs147500837	RCV005893363 RCV005893371
Colorectal cancer	Conflicting classifications of pathogenicity	rs201125492	RCV005893361
Congenital anemia	Likely benign	rs139202766	RCV005625545
Congenital dyserythropoietic anemia	Likely benign; Uncertain significance	rs111961345, rs531320636, rs767935615, rs778227051	RCV000312642 RCV000288162 RCV000400788 RCV000273984
Familial cancer of breast	Benign; Conflicting classifications of pathogenicity	rs12905385, rs201125492, rs372998688	RCV005894280 RCV005893360 RCV005903146
Gastric cancer	Benign; Likely benign	rs114208791, rs147500837	RCV005893365 RCV005893373
Lung cancer	Benign; Likely benign	rs16957109, rs114208791, rs147500837, rs377026916	RCV005915556 RCV005893367 RCV005893377 RCV005903207
Malignant lymphoma, large B-cell, diffuse	Benign	rs12905385	RCV005894281
Malignant tumor of esophagus	Benign; Likely benign	rs16957109, rs147500837	RCV005915553 RCV005893369
Melanoma	Benign; Likely benign	rs147500837	RCV005893376
Nonpapillary renal cell carcinoma	Uncertain significance	rs200071287	RCV005926867
Ovarian serous cystadenocarcinoma	Uncertain significance; Benign; Likely benign	rs751799284, rs147500837	RCV005925653 RCV005893374
Sarcoma	Benign; Likely benign; Conflicting classifications of pathogenicity	rs16957109, rs199584270, rs372671684, rs147500837	RCV005915555 RCV005928560 RCV005893378 RCV005893372
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs114208791, rs147500837	RCV005893366 RCV005893375

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abnormalities Drug Induced	Associate	22407294
Anemia	Associate	33401150
Anemia Diamond Blackfan	Associate	12434312
Anemia Dyserythropoietic Congenital	Associate	12434312, 16098079, 16141353, 19336738, 22407294, 22504250, 23716552, 29599085, 32160409, 32239177, 32293259, 32518175, 33075436, 33121234, 33401150
Anemia Dyserythropoietic Congenital	Stimulate	9345103
Anemia Hemolytic	Associate	33401150
Anemia Macrocytic	Associate	29599085
Bone Diseases	Associate	16098079
Corneal dystrophy Avellino type	Associate	33401150
Gallstones	Associate	16141353
Hydrops Fetalis	Associate	29599085
Iron Overload	Associate	29599085, 33401150
Jaundice	Associate	29599085

CDAN1 (codanin 1)