TMCO5A (transmembrane and coiled-coil domains 5A)

Gene

• Entrez ID: 145942
• Gene name: Transmembrane and coiled-coil domains 5A
• Gene symbol: TMCO5A
• Synonyms (NCBI Gene): TMCO5
• Chromosome: 15
• Chromosome location: 15q14

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT720516	hsa-miR-6750-3p	HITS-CLIP	19536157
MIRT720515	hsa-miR-28-3p	HITS-CLIP	19536157
MIRT720514	hsa-miR-1972	HITS-CLIP	19536157
MIRT720513	hsa-miR-345-5p	HITS-CLIP	19536157
MIRT720512	hsa-miR-4764-3p	HITS-CLIP	19536157
MIRT720511	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT720510	hsa-miR-4256	HITS-CLIP	19536157
MIRT720516	hsa-miR-6750-3p	HITS-CLIP	19536157
MIRT720515	hsa-miR-28-3p	HITS-CLIP	19536157
MIRT720514	hsa-miR-1972	HITS-CLIP	19536157
MIRT720513	hsa-miR-345-5p	HITS-CLIP	19536157
MIRT720512	hsa-miR-4764-3p	HITS-CLIP	19536157
MIRT720511	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT720510	hsa-miR-4256	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0031965	Component	Nuclear membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N6Q1
• Protein name: Transmembrane and coiled-coil domain-containing protein 5A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14992	TMCO5	13 → 287	TMCO5 family	Family

• Sequence:

  MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVE
  DEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSS
  PDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQETLKKIEEE
  LEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLS
  YMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLPH

• Sequence length: 288

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RECTUM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations