Gene Gene information from NCBI Gene database.
Entrez ID 1457
Gene name Casein kinase 2 alpha 1
Gene symbol CSNK2A1
Synonyms (NCBI Gene)
CK2A1CKIICka1Cka2OCNDS
Chromosome 20
Chromosome location 20p13
Summary Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is c
SNPs SNP information provided by dbSNP.
16
SNP ID Visualize variation Clinical significance Consequence
rs869312840 T>C Pathogenic Missense variant, coding sequence variant
rs869312845 C>T Likely-pathogenic, pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
rs869312846 A>G Pathogenic Splice donor variant
rs869312848 T>C Pathogenic Missense variant, coding sequence variant
rs869312849 T>C,G Pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
658
miRTarBase ID miRNA Experiments Reference
MIRT007207 hsa-miR-216b-5p ImmunoblotLuciferase reporter assayqRT-PCRWestern blot 23137536
MIRT007208 hsa-miR-337-3p ImmunoblotLuciferase reporter assayqRT-PCRWestern blot 23137536
MIRT007209 hsa-miR-760 ImmunoblotLuciferase reporter assayqRT-PCRWestern blot 23137536
MIRT007210 hsa-miR-186-5p ImmunoblotLuciferase reporter assayqRT-PCRWestern blot 23137536
MIRT030638 hsa-miR-22-3p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
ETS1 Unknown 19027835
NFKB1 Unknown 19027835
RELA Unknown 19027835
SP1 Unknown 19027835
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
72
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IDA 31135337
GO:0000166 Function Nucleotide binding IEA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IDA 31439799
GO:0000724 Process Double-strand break repair via homologous recombination IDA 18417535, 26811421, 29670289, 30612738, 35597237
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
115440 2457 ENSG00000101266
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P68400
Protein name Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Protein function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:117048
PDB 1JWH , 1NA7 , 1PJK , 2PVR , 2ZJW , 3AMY , 3AT2 , 3AT3 , 3AT4 , 3AXW , 3BQC , 3C13 , 3FWQ , 3H30 , 3JUH , 3MB6 , 3MB7 , 3NGA , 3NSZ , 3OWJ , 3OWK , 3OWL , 3PE1 , 3PE2 , 3PE4 , 3Q04 , 3Q9W , 3Q9X , 3Q9Y , 3Q9Z , 3QA0 , 3R0T , 3RPS , 3TAX , 3U4U , 3U87 , 3U9C , 3W8L , 3WAR , 3WIK , 3WIL , 3WOW , 4DGL , 4FBX , 4GRB , 4GUB , 4GYW , 4GYY , 4GZ3 , 4IB5 , 4KWP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 39 324 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). {ECO:0000269|PubMed:24962073}.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ribosome biogenesis in eukaryotes
NF-kappa B signaling pathway
Mitophagy - animal
Wnt signaling pathway
Adherens junction
Alzheimer disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Measles
PD-L1 expression and PD-1 checkpoint pathway in cancer
  Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
89
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CSNK2A1-related disorder Likely pathogenic; Pathogenic rs768238678, rs2122537652 RCV003394234
RCV003892850
CSNK2A1-related neurodevelopmental syndrome Likely pathogenic; Pathogenic rs2018100989 RCV001270882
Developmental disorder Likely pathogenic; Pathogenic rs2018124491 RCV003127743
Intellectual disability Likely pathogenic; Pathogenic rs2514672851 RCV005626791
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism spectrum disorder Conflicting classifications of pathogenicity rs1034583315 RCV003127746
Familial cancer of breast Benign; Likely benign rs143151604 RCV005904443
Neurodevelopmental disorder Uncertain significance rs2018548182 RCV003389151
Ovarian serous cystadenocarcinoma Benign; Likely benign rs143151604 RCV005904444
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35266446, 40179422
Adenoma Oxyphilic Associate 28975890
Alzheimer Disease Associate 28558704
Arthritis Rheumatoid Associate 25880754
Atrial Fibrillation Stimulate 35607269
Breast Neoplasms Associate 27746184, 37348024
Calcinosis Cutis Associate 28975890
Carcinogenesis Associate 27746184
Carcinoma Non Small Cell Lung Associate 38155968
Carcinoma Ovarian Epithelial Associate 26637171