Gene Gene information from NCBI Gene database.
Entrez ID 1456
Gene name Casein kinase 1 gamma 3
Gene symbol CSNK1G3
Synonyms (NCBI Gene)
CKI-gamma 3CSNK1G3L
Chromosome 5
Chromosome location 5q23.2
Summary This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spl
miRNA miRNA information provided by mirtarbase database.
531
miRTarBase ID miRNA Experiments Reference
MIRT028223 hsa-miR-33a-5p Sequencing 20371350
MIRT028663 hsa-miR-30a-5p Proteomics 18668040
MIRT710288 hsa-miR-6800-3p HITS-CLIP 19536157
MIRT710287 hsa-miR-4280 HITS-CLIP 19536157
MIRT710286 hsa-miR-4699-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 9925945
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 25500533
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604253 2456 ENSG00000151292
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6M4
Protein name Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1)
Protein function Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulat
PDB 2CHL , 2IZR , 2IZS , 2IZT , 2IZU , 4G16 , 4G17 , 4HGL , 4HGS , 6GRO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 43 296 Protein kinase domain Domain
PF12605 CK1gamma_C 328 417 Casein kinase 1 gamma C terminal Family
Sequence
Sequence length 447
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Hedgehog signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CSNK1G3-related disorder Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME GenCC
★★☆☆☆
Found in Text Mining + Unknown/Other Associations