LRFN5 (leucine rich repeat and fibronectin type III domain containing 5)

Gene

• Entrez ID: 145581
• Gene name: Leucine rich repeat and fibronectin type III domain containing 5
• Gene symbol: LRFN5
• Synonyms (NCBI Gene): C14orf146, FIGLER8, SALM5
• Chromosome: 14
• Chromosome location: 14q21.1
• Summary: This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1117556	hsa-miR-4282	CLIP-seq
MIRT1117557	hsa-miR-4717-5p	CLIP-seq
MIRT2033201	hsa-miR-106a	CLIP-seq
MIRT2033202	hsa-miR-106b	CLIP-seq
MIRT2033203	hsa-miR-1193	CLIP-seq
MIRT2033204	hsa-miR-139-5p	CLIP-seq
MIRT2033205	hsa-miR-17	CLIP-seq
MIRT2033206	hsa-miR-20a	CLIP-seq
MIRT2033207	hsa-miR-20b	CLIP-seq
MIRT2033208	hsa-miR-2681	CLIP-seq
MIRT2033209	hsa-miR-3065-5p	CLIP-seq
MIRT2033210	hsa-miR-3609	CLIP-seq
MIRT2033211	hsa-miR-3689a-5p	CLIP-seq
MIRT2033212	hsa-miR-3689b	CLIP-seq
MIRT2033213	hsa-miR-3689e	CLIP-seq
MIRT2033214	hsa-miR-3689f	CLIP-seq
MIRT2033215	hsa-miR-421	CLIP-seq
MIRT2033216	hsa-miR-4272	CLIP-seq
MIRT1117556	hsa-miR-4282	CLIP-seq
MIRT2033217	hsa-miR-4426	CLIP-seq
MIRT2033218	hsa-miR-4647	CLIP-seq
MIRT2033219	hsa-miR-4659a-3p	CLIP-seq
MIRT2033220	hsa-miR-4659b-3p	CLIP-seq
MIRT2033221	hsa-miR-4662b	CLIP-seq
MIRT1117557	hsa-miR-4717-5p	CLIP-seq
MIRT2033222	hsa-miR-4796-3p	CLIP-seq
MIRT2033223	hsa-miR-490-5p	CLIP-seq
MIRT2033224	hsa-miR-5096	CLIP-seq
MIRT2033225	hsa-miR-519d	CLIP-seq
MIRT2033226	hsa-miR-548ah	CLIP-seq
MIRT2033227	hsa-miR-622	CLIP-seq
MIRT2033228	hsa-miR-659	CLIP-seq
MIRT2033229	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27152329
GO:0009986	Component	Cell surface	IBA	21873635
GO:0043031	Process	Negative regulation of macrophage activation	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IDA	27152329
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:0098982	Component	GABA-ergic synapse	IBA	21873635
GO:0099061	Component	Integral component of postsynaptic density membrane	IBA	21873635
GO:0099560	Process	Synaptic membrane adhesion	IBA	21873635
GO:1905606	Process	Regulation of presynapse assembly	IBA	21873635

Other IDs

• MIM: 612811
• HGNC: 20360
• e!Ensembl: ENSG00000165379

Protein

• UniProt ID: Q96NI6
• Protein name: Leucine-rich repeat and fibronectin type-III domain-containing protein 5
• Protein function: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.
• PDB: 5XNP, 5XNQ, 5XWS, 5XWT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13306	LRR_5	56 → 213	BspA type Leucine rich repeat region (6 copies)	Repeat
  PF07679	I-set	287 → 374	Immunoglobulin I-set domain	Domain

• Sequence:

  MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLAD
  NFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS
  GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDH
  NMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN
  PLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE
  GQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIAS
  NPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK
  IVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGT
  MYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVAS
  VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENA
  QCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAV
  TNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI

• Sequence length: 719

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	27182965

Unknown
Disease term	Disease name	Evidence	References	Source
Mental depression	Major Depressive Disorder		29700475, 29662059	ClinVar
Neuroticism	Neuroticism			GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA
Mental Depression	Mental Depression			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Autism Spectrum Disorder	Associate	31152157
Mental Disorders	Associate	31152157
Stomach Neoplasms	Associate	35578189