Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	145567
Gene name	Tetratricopeptide repeat domain 7B
Gene symbol	TTC7B
Synonyms (NCBI Gene)	TTC7L1c14_5685
Chromosome	14
Chromosome location	14q32.11

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020039	hsa-miR-375	Microarray	20215506
MIRT021405	hsa-miR-9-5p	Microarray	17612493
MIRT049562	hsa-miR-92a-3p	CLASH	23622248
MIRT1461870	hsa-miR-1245b-3p	CLIP-seq
MIRT1461871	hsa-miR-125a-3p	CLIP-seq
MIRT1461872	hsa-miR-127-5p	CLIP-seq
MIRT1461873	hsa-miR-1285	CLIP-seq
MIRT1461874	hsa-miR-1293	CLIP-seq
MIRT1461875	hsa-miR-1587	CLIP-seq
MIRT1461876	hsa-miR-183	CLIP-seq
MIRT1461877	hsa-miR-23a	CLIP-seq
MIRT1461878	hsa-miR-23b	CLIP-seq
MIRT1461879	hsa-miR-23c	CLIP-seq
MIRT1461880	hsa-miR-3128	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461882	hsa-miR-3151	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT1461884	hsa-miR-3187-5p	CLIP-seq
MIRT1461885	hsa-miR-3613-3p	CLIP-seq
MIRT1461886	hsa-miR-3665	CLIP-seq
MIRT1461887	hsa-miR-378g	CLIP-seq
MIRT1461888	hsa-miR-3921	CLIP-seq
MIRT1461889	hsa-miR-3926	CLIP-seq
MIRT1461890	hsa-miR-4314	CLIP-seq
MIRT1461891	hsa-miR-4316	CLIP-seq
MIRT1461892	hsa-miR-4330	CLIP-seq
MIRT1461893	hsa-miR-4446-5p	CLIP-seq
MIRT1461894	hsa-miR-4459	CLIP-seq
MIRT1461895	hsa-miR-4470	CLIP-seq
MIRT1461896	hsa-miR-4483	CLIP-seq
MIRT1461897	hsa-miR-4486	CLIP-seq
MIRT1461898	hsa-miR-4492	CLIP-seq
MIRT1461899	hsa-miR-4498	CLIP-seq
MIRT1461900	hsa-miR-4640-5p	CLIP-seq
MIRT1461901	hsa-miR-4649-3p	CLIP-seq
MIRT1461902	hsa-miR-4651	CLIP-seq
MIRT1461903	hsa-miR-4653-5p	CLIP-seq
MIRT1461904	hsa-miR-4655-3p	CLIP-seq
MIRT1461905	hsa-miR-4656	CLIP-seq
MIRT1461906	hsa-miR-4674	CLIP-seq
MIRT1461907	hsa-miR-4675	CLIP-seq
MIRT1461908	hsa-miR-4710	CLIP-seq
MIRT1461909	hsa-miR-4717-3p	CLIP-seq
MIRT1461910	hsa-miR-4722-5p	CLIP-seq
MIRT1461911	hsa-miR-4726-5p	CLIP-seq
MIRT1461912	hsa-miR-4736	CLIP-seq
MIRT1461913	hsa-miR-4741	CLIP-seq
MIRT1461914	hsa-miR-4755-5p	CLIP-seq
MIRT1461915	hsa-miR-4779	CLIP-seq
MIRT1461916	hsa-miR-4796-3p	CLIP-seq
MIRT1461917	hsa-miR-486-3p	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT1461919	hsa-miR-495	CLIP-seq
MIRT1461920	hsa-miR-505	CLIP-seq
MIRT1461921	hsa-miR-520g	CLIP-seq
MIRT1461922	hsa-miR-520h	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461924	hsa-miR-608	CLIP-seq
MIRT1461925	hsa-miR-612	CLIP-seq
MIRT1461926	hsa-miR-640	CLIP-seq
MIRT1461927	hsa-miR-642a	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461929	hsa-miR-659	CLIP-seq
MIRT1461930	hsa-miR-762	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq
MIRT2138760	hsa-miR-1	CLIP-seq
MIRT2138761	hsa-miR-1207-3p	CLIP-seq
MIRT2138762	hsa-miR-138	CLIP-seq
MIRT1461875	hsa-miR-1587	CLIP-seq
MIRT2138763	hsa-miR-206	CLIP-seq
MIRT1461877	hsa-miR-23a	CLIP-seq
MIRT1461878	hsa-miR-23b	CLIP-seq
MIRT1461879	hsa-miR-23c	CLIP-seq
MIRT1461880	hsa-miR-3128	CLIP-seq
MIRT1461885	hsa-miR-3613-3p	CLIP-seq
MIRT1461895	hsa-miR-4470	CLIP-seq
MIRT2138764	hsa-miR-4473	CLIP-seq
MIRT1461898	hsa-miR-4492	CLIP-seq
MIRT1461899	hsa-miR-4498	CLIP-seq
MIRT1461905	hsa-miR-4656	CLIP-seq
MIRT2138765	hsa-miR-4663	CLIP-seq
MIRT1461906	hsa-miR-4674	CLIP-seq
MIRT1461907	hsa-miR-4675	CLIP-seq
MIRT1461913	hsa-miR-4741	CLIP-seq
MIRT2138766	hsa-miR-512-3p	CLIP-seq
MIRT2138767	hsa-miR-520f	CLIP-seq
MIRT2138768	hsa-miR-613	CLIP-seq
MIRT1461929	hsa-miR-659	CLIP-seq
MIRT1461930	hsa-miR-762	CLIP-seq
MIRT1461872	hsa-miR-127-5p	CLIP-seq
MIRT1461874	hsa-miR-1293	CLIP-seq
MIRT1461876	hsa-miR-183	CLIP-seq
MIRT2359640	hsa-miR-3127-3p	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT2359641	hsa-miR-3180	CLIP-seq
MIRT2359642	hsa-miR-3180-3p	CLIP-seq
MIRT2359643	hsa-miR-3189-3p	CLIP-seq
MIRT2359644	hsa-miR-3196	CLIP-seq
MIRT2359645	hsa-miR-4260	CLIP-seq
MIRT1461894	hsa-miR-4459	CLIP-seq
MIRT2138764	hsa-miR-4473	CLIP-seq
MIRT1461896	hsa-miR-4483	CLIP-seq
MIRT1461902	hsa-miR-4651	CLIP-seq
MIRT1461909	hsa-miR-4717-3p	CLIP-seq
MIRT1461910	hsa-miR-4722-5p	CLIP-seq
MIRT1461915	hsa-miR-4779	CLIP-seq
MIRT1461917	hsa-miR-486-3p	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT2138766	hsa-miR-512-3p	CLIP-seq
MIRT2138767	hsa-miR-520f	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461924	hsa-miR-608	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq
MIRT1461881	hsa-miR-3150a-3p	CLIP-seq
MIRT1461883	hsa-miR-3175	CLIP-seq
MIRT1461918	hsa-miR-491-5p	CLIP-seq
MIRT1461923	hsa-miR-541	CLIP-seq
MIRT1461928	hsa-miR-654-5p	CLIP-seq
MIRT1461931	hsa-miR-939	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23229899, 26571211, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	23229899
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23229899
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IDA	23229899, 26571211
GO:0072659	Process	Protein localization to plasma membrane	IBA
GO:0072659	Process	Protein localization to plasma membrane	IDA	23229899, 26571211

MIM	HGNC	e!Ensembl
620060	19858	ENSG00000165914

Q86TV6

Protein name

Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)

Protein function

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging

PDB

5DSE , 6BQ1 , 9B9G , 9BAX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13181	TPR_8	397 → 430	Tetratricopeptide repeat	Repeat
PF12895	ANAPC3	494 → 575		Domain
PF13424	TPR_12	728 → 795		Repeat
PF13181	TPR_8	798 → 831	Tetratricopeptide repeat	Repeat

Sequence

MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH
PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY
ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG
RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN
TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL
KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY
SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ
ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD
EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA
TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ
EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY
SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP
RVL

Sequence length

843

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANXIETY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cardiovascular Diseases	Associate	22453632	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Associate	22453632	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Inhibit	36193074	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36193074	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	37990988	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	22453632	★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC7B (tetratricopeptide repeat domain 7B)