ABHD12B (abhydrolase domain containing 12B)

Gene

• Entrez ID: 145447
• Gene name: Abhydrolase domain containing 12B
• Gene symbol: ABHD12B
• Synonyms (NCBI Gene): BEM46L3, C14orf29, c14_5314
• Chromosome: 14
• Chromosome location: 14q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018993	hsa-miR-335-5p	Microarray	18185580
MIRT759540	hsa-miR-2053	CLIP-seq
MIRT759541	hsa-miR-31	CLIP-seq
MIRT759542	hsa-miR-3662	CLIP-seq
MIRT759543	hsa-miR-3674	CLIP-seq
MIRT759544	hsa-miR-4777-5p	CLIP-seq
MIRT1923838	hsa-miR-128	CLIP-seq
MIRT1923839	hsa-miR-27a	CLIP-seq
MIRT1923840	hsa-miR-27b	CLIP-seq
MIRT1923841	hsa-miR-335	CLIP-seq
MIRT1923842	hsa-miR-4277	CLIP-seq
MIRT1923843	hsa-miR-4314	CLIP-seq
MIRT1923844	hsa-miR-4488	CLIP-seq
MIRT1923845	hsa-miR-4492	CLIP-seq
MIRT1923846	hsa-miR-4498	CLIP-seq
MIRT1923847	hsa-miR-4505	CLIP-seq
MIRT1923848	hsa-miR-4646-5p	CLIP-seq
MIRT1923849	hsa-miR-4667-5p	CLIP-seq
MIRT1923850	hsa-miR-4697-5p	CLIP-seq
MIRT1923851	hsa-miR-4700-5p	CLIP-seq
MIRT1923852	hsa-miR-4747-5p	CLIP-seq
MIRT1923853	hsa-miR-637	CLIP-seq
MIRT1923854	hsa-miR-762	CLIP-seq
MIRT1923838	hsa-miR-128	CLIP-seq
MIRT1923839	hsa-miR-27a	CLIP-seq
MIRT1923840	hsa-miR-27b	CLIP-seq
MIRT1923841	hsa-miR-335	CLIP-seq
MIRT1923842	hsa-miR-4277	CLIP-seq
MIRT1923843	hsa-miR-4314	CLIP-seq
MIRT1923844	hsa-miR-4488	CLIP-seq
MIRT1923845	hsa-miR-4492	CLIP-seq
MIRT1923846	hsa-miR-4498	CLIP-seq
MIRT1923847	hsa-miR-4505	CLIP-seq
MIRT1923848	hsa-miR-4646-5p	CLIP-seq
MIRT1923849	hsa-miR-4667-5p	CLIP-seq
MIRT1923850	hsa-miR-4697-5p	CLIP-seq
MIRT1923851	hsa-miR-4700-5p	CLIP-seq
MIRT1923852	hsa-miR-4747-5p	CLIP-seq
MIRT1923853	hsa-miR-637	CLIP-seq
MIRT1923854	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004622	Function	Lysophospholipase activity	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0006660	Process	Phosphatidylserine catabolic process	IBA	21873635
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0047372	Function	Acylglycerol lipase activity	IBA	21873635
GO:0052651	Process	Monoacylglycerol catabolic process	IBA	21873635
GO:0098734	Process	Macromolecule depalmitoylation	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q7Z5M8
• Protein name: Protein ABHD12B (EC 3.-.-.-) (Abhydrolase domain-containing protein 12B) (Alpha/beta hydrolase domain-containing protein 12B)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12146	Hydrolase_4	137 → 280	Serine aminopeptidase, S33	Family

• Sequence:

  MDAQDCQAAASPEPPGPPARSCVAAWWDMVDRNLRYFPHSCSMLGRKIAALYDSFTSKSL
  KEHVFLPLIDMLIYFNFFKAPFLVDLKKPELKIPHTVNFYLRVEPGVMLGIWHTVPSCRG
  EDAKGKDCCWYEAALRDGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFG
  DSTGKPTEEGLTTDAICVYEWTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAI
  VLEAPFTNMWVASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILH
  GEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLLITVRDFLSKQ
  WS

• Sequence length: 362

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Embryonal	Associate	26659575
Chronic Periodontitis	Associate	25056994, 36360171
Periodontitis	Associate	35179257
Testicular Germ Cell Tumor	Associate	26659575