Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1454
Gene name Gene Name - the full gene name approved by the HGNC.
Casein kinase 1 epsilon
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CSNK1E
Synonyms (NCBI Gene) Gene synonyms aliases
CKIe, CKIepsilon, HCKIE
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The enc
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047921 hsa-miR-30c-5p CLASH 23622248
MIRT045612 hsa-miR-149-5p CLASH 23622248
MIRT676632 hsa-miR-646 HITS-CLIP 23824327
MIRT676630 hsa-miR-1207-3p HITS-CLIP 23824327
MIRT676629 hsa-miR-6814-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0003723 Function RNA binding HDA 22681889
GO:0004672 Function Protein kinase activity IDA 14722104, 17244647
GO:0004672 Function Protein kinase activity ISS
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600863 2453 ENSG00000213923
Protein
UniProt ID P49674
Protein name Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Protein function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phos
PDB 4HNI , 4HOK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 9 270 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Sequence
Sequence length 416
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  FoxO signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Hippo signaling pathway
Hippo signaling pathway - multiple species
Circadian rhythm
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
  WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
AURKA Activation by TPX2
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Epileptic encephalopathy EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 rs587776508, rs121918334, rs121918317, rs121918321, rs74315390, rs28939684, rs74315391, rs74315392, rs118192244, rs121918622, rs121918623, rs121917953, rs121917955, rs121918624, rs121918625
View all (860 more)
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22981886, 22367616
Unknown
Disease term Disease name Evidence References Source
Developmental And Epileptic Encephalopathy genetic developmental and epileptic encephalopathy GenCC
Mastocytosis Mastocytosis GWAS
Keratoconus Keratoconus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic lateral sclerosis 1 Associate 29881994
Atypical Squamous Cells of the Cervix Associate 35266015
Bipolar Disorder Associate 18228528, 26283580
Breast Neoplasms Associate 20507565, 23822714, 24098497, 26327509
Carcinogenesis Associate 32071557
Carcinoma Adenoid Cystic Associate 12368205
Carcinoma Hepatocellular Associate 26482619, 33540684, 33818013
Carcinoma in Situ Stimulate 35266015
Colitis Ulcerative Associate 38302916
Colorectal Neoplasms Stimulate 27492458