Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1453
Gene name Gene Name - the full gene name approved by the HGNC.
Casein kinase 1 delta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CSNK1D
Synonyms (NCBI Gene) Gene synonyms aliases
ASPS, CKI-delta, CKId, CKIdelta, FASPS2, HCKID
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FASPS2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apop
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs104894561 T>C Pathogenic Non coding transcript variant, missense variant, coding sequence variant
rs397514693 T>C Pathogenic Non coding transcript variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001640 hsa-let-7b-5p pSILAC 18668040
MIRT016176 hsa-miR-590-3p Sequencing 20371350
MIRT001640 hsa-let-7b-5p Proteomics;Other 18668040
MIRT610086 hsa-miR-8485 HITS-CLIP 23824327
MIRT610085 hsa-miR-329-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0000139 Component Golgi membrane IEA
GO:0001934 Process Positive regulation of protein phosphorylation IMP 20412773
GO:0004672 Function Protein kinase activity IDA 16618118
GO:0004672 Function Protein kinase activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600864 2452 ENSG00000141551
Protein
UniProt ID P48730
Protein name Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Protein function Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally
PDB 3UYS , 3UYT , 3UZP , 4HGT , 4HNF , 4KB8 , 4KBA , 4KBC , 4KBK , 4TN6 , 4TW9 , 4TWC , 5IH4 , 5IH5 , 5IH6 , 5MQV , 5OKT , 5W4W , 6F1W , 6F26 , 6GZM , 6HMP , 6HMR , 6PXN , 6PXO , 6PXP , 6RCG , 6RCH , 6RU6 , 6RU7 , 6RU8 , 7NZY , 7P7F , 7P7G , 7P7H , 7QR9 , 7QRA , 7QRB , 8D7M , 8D7N , 8D7O , 8D7P , 8IZC , 8VXD , 8VXF , 9B3S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 9 271 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in
Sequence
Sequence length 415
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Hedgehog signaling pathway
Hippo signaling pathway
Gap junction
Circadian rhythm
  COPII-mediated vesicle transport
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
AURKA Activation by TPX2
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Advanced sleep phase syndrome Familial advanced sleep-phase syndrome, Advanced Sleep-Phase Syndrome, Familial rs121908635, rs104894561, rs397514693, rs1559332542 15800623
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Migraine Migraine Disorders rs794727411
Unknown
Disease term Disease name Evidence References Source
Migraine with aura Migraine with Aura ClinVar
Advanced Sleep Phase Syndrome advanced sleep phase syndrome GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acute On Chronic Liver Failure Associate 26173605
Adenocarcinoma of Lung Associate 35441736
Alzheimer Disease Associate 14761950, 21811019
Bipolar Disorder Associate 26283580
Breast Neoplasms Associate 17855657
Carcinogenesis Associate 32071557
Carcinoma Hepatocellular Associate 37688771
Carcinoma Squamous Cell Associate 32991423
Chronobiology Disorders Associate 35163208
Colorectal Neoplasms Stimulate 26809274