Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
145270
Gene name Gene Name - the full gene name approved by the HGNC.
Proline rich membrane anchor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRIMA1
Synonyms (NCBI Gene) Gene synonyms aliases
PRIMA
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.12
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023651 hsa-miR-1-3p Microarray 18668037
MIRT707924 hsa-miR-1277-5p HITS-CLIP 21572407
MIRT707923 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT707922 hsa-miR-3668 HITS-CLIP 21572407
MIRT707921 hsa-miR-7852-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IEA
GO:0016021 Component Integral component of membrane IEA
GO:0042135 Process Neurotransmitter catabolic process IEA
GO:0045202 Component Synapse IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613851 18319 ENSG00000175785
Protein
UniProt ID Q86XR5
Protein name Proline-rich membrane anchor 1 (PRiMA)
Protein function Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16101 PRIMA1 37 153 Family
Sequence
Sequence length 153
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Muscular dystrophy Muscular Dystrophy rs200198778, rs121908110, rs121908185, rs58932704, rs61672878, rs60458016, rs387906881, rs397509417, rs267607644, rs267607634, rs59332535, rs797045898, rs755660222, rs142908436, rs886039913
View all (15 more)
22906800
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 22511943 ClinVar
Insomnia Insomnia GWAS
Mental Depression Mental Depression GWAS
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26482433
Adenoma Associate 28753106
Atherosclerosis Associate 31406157
Breast Neoplasms Associate 16168122, 22982566
Colorectal Neoplasms Associate 26482433, 28753106
Death Associate 27863474
Drug Related Side Effects and Adverse Reactions Stimulate 15491287, 16398657
Drug Related Side Effects and Adverse Reactions Associate 22982566, 27533450
Ectrodactyly cleft lip palate syndrome Associate 23355676
Hypoxia Inhibit 22982566