SERPINA12 (serpin family A member 12)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 145264
Gene name Serpin family A member 12
Gene symbol SERPINA12
Synonyms (NCBI Gene)
OL-64
Chromosome 14
Chromosome location 14q32.13
miRNA miRNA information provided by mirtarbase database.
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (1)
miRTarBase ID miRNA Experiments Reference
MIRT045039 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617471 18359 ENSG00000165953
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IW75
Protein name Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin)
Protein function Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
PDB 4IF8 , 4Y3K , 4Y40 , 5EI0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 50 → 411 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in visceral adipose tissues. {ECO:0000269|PubMed:16030142}.
Sequence
Sequence length 414
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hereditary palmoplantar keratoderma, Gamborg-Nielsen type Pathogenic rs1445117727 RCV003319152
Show/Hide Text Mining Associations (35)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Associate 26670468
Atherosclerosis Associate 20145358, 30387901, 33849644
Axial Spondyloarthritis Associate 33849644
Breast Neoplasms Associate 36125462
Cardiovascular Diseases Associate 33849644, 35615549
Coronary Artery Disease Associate 20145358
Diabetes Gestational Inhibit 25608237
Diabetes Mellitus Associate 24367155, 25608237, 35615549
Diabetes Mellitus Type 2 Associate 19801900, 32917052
Endometrial Neoplasms Associate 36291064