Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1452
Gene name Gene Name - the full gene name approved by the HGNC.
Casein kinase 1 alpha 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CSNK1A1
Synonyms (NCBI Gene) Gene synonyms aliases
CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q32
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006267 hsa-miR-155-5p Luciferase reporter assay 22350414
MIRT006267 hsa-miR-155-5p Luciferase reporter assay 22350414
MIRT006267 hsa-miR-155-5p Luciferase reporter assay 22350414
MIRT006267 hsa-miR-155-5p Luciferase reporter assay 22350414
MIRT006267 hsa-miR-155-5p Luciferase reporter assay 22350414
Transcription factors
Transcription factor Regulation Reference
SOX17 Repression 24407731
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000777 Component Condensed chromosome kinetochore IEA
GO:0004672 Function Protein kinase activity ISS
GO:0004672 Function Protein kinase activity TAS 10777483
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 18305108, 19364825, 25500533
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600505 2451 ENSG00000113712
Protein
UniProt ID P48729
Protein name Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
Protein function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (Pub
PDB 5FQD , 6GZD , 7WTT , 8G66
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 17 260 Protein kinase domain Domain
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Wnt signaling pathway
Hedgehog signaling pathway
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Esophagus neoplasm Esophageal Neoplasms, Malignant neoplasm of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21642993
Unknown
Disease term Disease name Evidence References Source
Biliary Atresia Biliary Atresia GWAS
Astrocytoma Astrocytoma GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anophthalmia with pulmonary hypoplasia Associate 32029502
Brain Concussion Stimulate 30644102
Breast Neoplasms Inhibit 31462314
Carcinoma Hepatocellular Associate 35985475, 37149115
Chromosome 5q Deletion Syndrome Associate 17916100
Colonic Neoplasms Associate 27031502
Colorectal Neoplasms Associate 23739040, 34536148
Colorectal Neoplasms Stimulate 29409464
Delayed Cranial Ossification due to CBFB Haploinsufficiency Associate 35617825
DNA Virus Infections Associate 19759023, 20157532