CSN3 (casein kappa)

Gene

• Entrez ID: 1448
• Gene name: Casein kappa
• Gene symbol: CSN3
• Synonyms (NCBI Gene): CNS10, CSN10, CSNK, KCA
• Chromosome: 4
• Chromosome location: 4q13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018995	hsa-miR-335-5p	Microarray	18185580
MIRT030202	hsa-miR-26b-5p	Microarray	19088304
MIRT912032	hsa-miR-1253	CLIP-seq
MIRT912033	hsa-miR-185	CLIP-seq
MIRT912034	hsa-miR-3160-3p	CLIP-seq
MIRT912035	hsa-miR-3173-3p	CLIP-seq
MIRT912036	hsa-miR-4306	CLIP-seq
MIRT912037	hsa-miR-4428	CLIP-seq
MIRT912038	hsa-miR-4644	CLIP-seq
MIRT912039	hsa-miR-4677-3p	CLIP-seq
MIRT912040	hsa-miR-4679	CLIP-seq
MIRT2206283	hsa-miR-19a	CLIP-seq
MIRT2206284	hsa-miR-19b	CLIP-seq
MIRT2206285	hsa-miR-3119	CLIP-seq
MIRT912037	hsa-miR-4428	CLIP-seq
MIRT2206286	hsa-miR-4715-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	7979373
GO:0007595	Process	Lactation	IBA	21873635
GO:0007595	Process	Lactation	IDA	7979373
GO:0050821	Process	Protein stabilization	IBA	21873635
GO:0050821	Process	Protein stabilization	IDA	7979373
GO:0055085	Process	Transmembrane transport	TAS

Other IDs

• MIM: 601695
• HGNC: 2446
• e!Ensembl: ENSG00000171209

Protein

• UniProt ID: P07498
• Protein name: Kappa-casein
• Protein function: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00997	Casein_kappa	21 → 181	Kappa casein	Family

• Tissue specificity: TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
• Sequence:

  MKSFLLVVNALALTLPFLAVEVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGT
  NLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLPNSHPPTVVRRPNLHPSFIAI
  PPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIITSTPETTTVAVTPP
  TA

• Sequence length: 182

Pathways

Reactome:

Miscellaneous transport and binding events

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	31408975
Carcinoma Non Small Cell Lung	Associate	34526525
Cerebral Infarction	Associate	22536414
Diabetes Mellitus	Associate	29305679
Hypoxia Brain	Associate	16396931
Prostatic Neoplasms	Associate	36430833
Squamous Cell Carcinoma of Head and Neck	Associate	33530209
Stroke	Associate	22536414
Vascular Diseases	Associate	29305679