KICS2 (KICSTOR subunit 2)

Gene

• Entrez ID: 144577
• Gene name: KICSTOR subunit 2
• Gene symbol: KICS2
• Synonyms (NCBI Gene): C12orf66, MRT83
• Chromosome: 12
• Chromosome location: 12q14.2

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005764	Component	Lysosome	IDA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	NAS	28199306
GO:0005765	Component	Lysosomal membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IBA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	28199306
GO:0042149	Process	Cellular response to glucose starvation	IBA
GO:0042149	Process	Cellular response to glucose starvation	IMP	28199306
GO:0045171	Component	Intercellular bridge	IDA
GO:0061462	Process	Protein localization to lysosome	IBA
GO:0061462	Process	Protein localization to lysosome	IMP	28199306
GO:0140007	Component	KICSTOR complex	IBA
GO:0140007	Component	KICSTOR complex	IDA	28199306
GO:0140007	Component	KICSTOR complex	NAS	28199306
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	28199306

Other IDs

• MIM: 617420
• HGNC: 26517
• e!Ensembl: ENSG00000174206

Protein

• UniProt ID: Q96MD2
• Protein name: KICSTOR subunit 2 (KICSTOR complex protein C12orf66)
• Protein function: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09404	C12orf66_like	7 → 444	KICSTOR complex C12orf66 like	Family

• Sequence:

  MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAH
  LAAAEKVYHSLTYLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEE
  LLSHLSEQLCFFVQARMEMADFYEKMYTLSTQKFINAEELVGLLDAIMKKYSSRFHHPIL
  SPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHL
  FGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGK
  ISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMH
  WPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFI
  SFLNEVSLALKNPKVFASLKPGAKG

• Sequence length: 445

Pathways

Reactome:

Amino acids regulate mTORC1