Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1445
Gene name Gene Name - the full gene name approved by the HGNC.	C-terminal Src kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CSK
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-re

Show/Hide all(74)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003960	hsa-miR-140-5p	Microarray	17875710
MIRT030606	hsa-miR-24-3p	Microarray	19748357
MIRT035928	hsa-miR-1180-3p	CLASH	23622248
MIRT755804	hsa-miR-192-3p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay	36914869
MIRT911892	hsa-miR-1225-5p	CLIP-seq
MIRT911893	hsa-miR-1302	CLIP-seq
MIRT911894	hsa-miR-130a	CLIP-seq
MIRT911895	hsa-miR-130b	CLIP-seq
MIRT911896	hsa-miR-148a	CLIP-seq
MIRT911897	hsa-miR-148b	CLIP-seq
MIRT911898	hsa-miR-151-5p	CLIP-seq
MIRT911899	hsa-miR-151b	CLIP-seq
MIRT911900	hsa-miR-152	CLIP-seq
MIRT911901	hsa-miR-2110	CLIP-seq
MIRT911902	hsa-miR-2467-5p	CLIP-seq
MIRT911903	hsa-miR-301a	CLIP-seq
MIRT911904	hsa-miR-301b	CLIP-seq
MIRT911905	hsa-miR-3150b-3p	CLIP-seq
MIRT911906	hsa-miR-3188	CLIP-seq
MIRT911907	hsa-miR-342-3p	CLIP-seq
MIRT911908	hsa-miR-346	CLIP-seq
MIRT911909	hsa-miR-365	CLIP-seq
MIRT911910	hsa-miR-3656	CLIP-seq
MIRT911911	hsa-miR-3660	CLIP-seq
MIRT911912	hsa-miR-3662	CLIP-seq
MIRT911913	hsa-miR-3666	CLIP-seq
MIRT911914	hsa-miR-3682-5p	CLIP-seq
MIRT911915	hsa-miR-3975	CLIP-seq
MIRT911916	hsa-miR-4271	CLIP-seq
MIRT911917	hsa-miR-4279	CLIP-seq
MIRT911918	hsa-miR-4295	CLIP-seq
MIRT911919	hsa-miR-4298	CLIP-seq
MIRT911920	hsa-miR-4457	CLIP-seq
MIRT911921	hsa-miR-4462	CLIP-seq
MIRT911922	hsa-miR-4526	CLIP-seq
MIRT911923	hsa-miR-454	CLIP-seq
MIRT911924	hsa-miR-4641	CLIP-seq
MIRT911925	hsa-miR-4725-3p	CLIP-seq
MIRT911926	hsa-miR-4731-5p	CLIP-seq
MIRT911927	hsa-miR-4732-3p	CLIP-seq
MIRT911928	hsa-miR-4750	CLIP-seq
MIRT911929	hsa-miR-4784	CLIP-seq
MIRT911930	hsa-miR-485-5p	CLIP-seq
MIRT911931	hsa-miR-513b	CLIP-seq
MIRT911932	hsa-miR-541	CLIP-seq
MIRT911933	hsa-miR-578	CLIP-seq
MIRT911934	hsa-miR-602	CLIP-seq
MIRT911935	hsa-miR-643	CLIP-seq
MIRT911936	hsa-miR-885-3p	CLIP-seq
MIRT911894	hsa-miR-130a	CLIP-seq
MIRT911895	hsa-miR-130b	CLIP-seq
MIRT911896	hsa-miR-148a	CLIP-seq
MIRT911897	hsa-miR-148b	CLIP-seq
MIRT911898	hsa-miR-151-5p	CLIP-seq
MIRT911899	hsa-miR-151b	CLIP-seq
MIRT911900	hsa-miR-152	CLIP-seq
MIRT911903	hsa-miR-301a	CLIP-seq
MIRT911904	hsa-miR-301b	CLIP-seq
MIRT911905	hsa-miR-3150b-3p	CLIP-seq
MIRT911937	hsa-miR-342-5p	CLIP-seq
MIRT911913	hsa-miR-3666	CLIP-seq
MIRT911918	hsa-miR-4295	CLIP-seq
MIRT911921	hsa-miR-4462	CLIP-seq
MIRT911923	hsa-miR-454	CLIP-seq
MIRT911938	hsa-miR-4664-5p	CLIP-seq
MIRT911929	hsa-miR-4784	CLIP-seq
MIRT911934	hsa-miR-602	CLIP-seq
MIRT1970311	hsa-miR-4417	CLIP-seq
MIRT1970312	hsa-miR-4437	CLIP-seq
MIRT911932	hsa-miR-541	CLIP-seq
MIRT911932	hsa-miR-541	CLIP-seq
MIRT911924	hsa-miR-4641	CLIP-seq
MIRT2509566	hsa-miR-4758-3p	CLIP-seq
MIRT2509567	hsa-miR-552	CLIP-seq

Show/Hide all(53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002682	Process	Regulation of immune system process	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	TAS	1945408
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	7507203, 10026153, 10790433, 12446738, 14665621, 15683240, 16354697, 17911601, 18070987, 18614016, 19167335, 21930792, 24902122, 28514442, 31980649, 32296183, 32707033, 33961781
GO:0005515	Function	Protein binding	TAS	8890164
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005737	Component	Cytoplasm	TAS	8890164
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IPI	10790433
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0006468	Process	Protein phosphorylation	TAS	1945408
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0031295	Process	T cell costimulation	TAS
GO:0032715	Process	Negative regulation of interleukin-6 production	IEA
GO:0034236	Function	Protein kinase A catalytic subunit binding	IPI	17911601
GO:0034332	Process	Adherens junction organization	IBA
GO:0034332	Process	Adherens junction organization	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042802	Function	Identical protein binding	IPI	19888460
GO:0042997	Process	Negative regulation of Golgi to plasma membrane protein transport	IDA	20605918
GO:0045779	Process	Negative regulation of bone resorption	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0050765	Process	Negative regulation of phagocytosis	IEA
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IEA
GO:0050868	Process	Negative regulation of T cell activation	IEA
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0060368	Process	Regulation of Fc receptor mediated stimulatory signaling pathway	IBA
GO:0060368	Process	Regulation of Fc receptor mediated stimulatory signaling pathway	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070064	Function	Proline-rich region binding	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0071375	Process	Cellular response to peptide hormone stimulus	IEA
GO:1990782	Function	Protein tyrosine kinase binding	IEA

MIM	HGNC	e!Ensembl
124095	2444	ENSG00000103653

Protein

UniProt ID

P41240

Protein name

Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)

Protein function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) inc

PDB

1BYG , 1CSK , 3D7T , 3D7U , 3EAC , 3EAZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00018	SH3_1	15 → 62	SH3 domain	Domain
PF00017	SH2	82 → 156	SH2 domain	Domain
PF07714	PK_Tyr_Ser-Thr	195 → 440	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.

Sequence

MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL

Sequence length

450

Interactions

View interactions

	KEGG		Reactome
	Epithelial cell signaling in Helicobacter pylori infection		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling PD-1 signaling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Celiac disease	Celiac disease	N/A	N/A	GWAS
Hypertension	Hypertension, Hypertension (confirmatory factor analysis Factor 12), Hypertension (PheCode 401), Essential hypertension (PheCode 401.1)	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	15208781, 27092776, 28874816
Arthritis Rheumatoid	Inhibit	28874816
Breast Neoplasms	Associate	14704150, 20010872, 29987050
Carcinoma Hepatocellular	Associate	32335258, 40612868
Carcinoma Lobular	Associate	19583841
Carcinoma Non Small Cell Lung	Associate	25163517
Carcinoma Squamous Cell	Associate	33671013
Celiac Disease	Associate	36814110
Cleft Palate	Associate	32241273
Colonic Neoplasms	Associate	7681838
Colorectal Neoplasms	Associate	11161376, 20010872
Death	Associate	23593342
Diabetes Mellitus Type 1	Associate	15208781
Hypertension	Associate	20921432, 28273873
Hypomagnesemia primary	Associate	16103120
IgA Vasculitis	Associate	26458874
Inflammation	Stimulate	31703690
Lens Diseases	Associate	31703690
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	36272407
Leukemia Myeloid Acute	Associate	33592500, 40255396
Lupus Erythematosus Systemic	Associate	17195233, 23042117
Medulloblastoma	Associate	33345275
Mesothelioma Malignant	Associate	27391433
Neoplasm Metastasis	Associate	27574806
Neoplasms	Associate	16103120, 17525734, 27574806, 31125786, 32335258
Neoplasms	Inhibit	31125786, 38235873
Osteosarcoma	Associate	16421247
Sarcoma	Inhibit	38235873
Sarcoma Kaposi	Associate	10640727
Scleroderma Systemic	Associate	22407130, 25569146, 32977850
Stomach Neoplasms	Associate	28460635, 38235873
Urinary Bladder Neoplasms	Associate	16103120
Uterine Cervical Neoplasms	Associate	33671013

CSK (C-terminal Src kinase)