Gene Gene information from NCBI Gene database.
Entrez ID 144108
Gene name SPT2 chromatin protein domain containing 1
Gene symbol SPTY2D1
Synonyms (NCBI Gene)
Spt2
Chromosome 11
Chromosome location 11p15.1
miRNA miRNA information provided by mirtarbase database.
764
miRTarBase ID miRNA Experiments Reference
MIRT022843 hsa-miR-124-3p Microarray 18668037
MIRT023474 hsa-miR-23b-3p Sequencing 20371350
MIRT031246 hsa-miR-19b-3p Sequencing 20371350
MIRT045141 hsa-miR-186-5p CLASH 23622248
MIRT698883 hsa-miR-379-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0001042 Function RNA polymerase I core binding ISS
GO:0003677 Function DNA binding IBA
GO:0003677 Function DNA binding IDA 23378026
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
621282 26818 ENSG00000179119
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q68D10
Protein name Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)
Protein function Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for th
PDB 5BS7 , 5BSA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08243 SPT2 581 682 SPT2 chromatin protein Domain
Sequence
MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKAL
EEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTD
REYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQ
FEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGT
KLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSL
REGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPH
NKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTN
DSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS
GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE
TISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSE
MEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGM
QEDLEEMRREEEEMQRRRAKKL
KRR
Sequence length 685
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Cholangiocarcinoma Associate 29271183
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Associate 35691597
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 35691597
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Associate 35665752
★☆☆☆☆
Found in Text Mining only
Dyslipidemias Associate 26722495
★☆☆☆☆
Found in Text Mining only
Thyroid Neoplasms Associate 35562181
★☆☆☆☆
Found in Text Mining only