CSF2 (colony stimulating factor 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1437
Gene name Gene Name - the full gene name approved by the HGNC.
Colony stimulating factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CSF2
Synonyms (NCBI Gene) Gene synonyms aliases
CSF, GMCSF
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster o
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
miRTarBase ID miRNA Experiments Reference
MIRT736497 hsa-miR-4697-3p RNA-seq, qRT-PCR 33045840
MIRT911706 hsa-miR-2278 CLIP-seq
MIRT911707 hsa-miR-433 CLIP-seq
MIRT911708 hsa-miR-4660 CLIP-seq
MIRT911709 hsa-miR-4712-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
Transcription factor Regulation Reference
CREBBP Unknown 20439113
CTCF Unknown 19158269
ETS1 Unknown 12475968
ETS2 Activation 12646185
JUN Unknown 15840658
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(51)
GO ID Ontology Definition Evidence Reference
GO:0001821 Process Histamine secretion IEA
GO:0001892 Process Embryonic placenta development IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IDA 3925454, 9722506
GO:0005125 Function Cytokine activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
138960 2434 ENSG00000164400
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04141
Protein name Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)
Protein function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
PDB 1CSG , 2GMF , 4NKQ , 4RS1 , 5C7X , 5D70 , 5D71 , 5D72 , 6BFQ , 6BFS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01109 GM_CSF 18 → 139 Granulocyte-macrophage colony-stimulating factor Domain
Sequence
Sequence length 144
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Shigellosis
Amoebiasis
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Coronavirus disease - COVID-19
Transcriptional misregulation in cancer
Acute myeloid leukemia
Rheumatoid arthritis 		  Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Interleukin receptor SHC signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease (MTAG) N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Show/Hide Text Mining Associations (401)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 31810489
Abnormalities Drug Induced Associate 26990868
Abortion Spontaneous Stimulate 17482605
Acidosis Lactic Associate 31924656
Acquired Immunodeficiency Syndrome Associate 10572106
Acute Coronary Syndrome Associate 35563407
Acute Coronary Syndrome Stimulate 39399429
Acute On Chronic Liver Failure Stimulate 33717119
Acute Phase Reaction Associate 1997656, 29920351
Adenocarcinoma Associate 11583970, 31635541