Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	143686
Gene name	Sestrin 3
Gene symbol	SESN3
Synonyms (NCBI Gene)	SEST3
Chromosome	11
Chromosome location	11q21
Summary	This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO tr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016230	hsa-miR-590-3p	Sequencing	20371350
MIRT017124	hsa-miR-335-5p	Microarray	18185580
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT574441	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT565744	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT565745	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT565743	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT565742	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT565740	hsa-miR-496	PAR-CLIP	20371350
MIRT565741	hsa-miR-3153	PAR-CLIP	20371350
MIRT565739	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT565738	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT565737	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT565736	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT565735	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT565734	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT565733	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT565732	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565731	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT565730	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT565729	hsa-miR-3654	PAR-CLIP	20371350
MIRT565728	hsa-miR-1243	PAR-CLIP	20371350
MIRT565727	hsa-miR-4519	PAR-CLIP	20371350
MIRT565726	hsa-miR-5191	PAR-CLIP	20371350
MIRT565725	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT565724	hsa-miR-3657	PAR-CLIP	20371350
MIRT565723	hsa-miR-4669	PAR-CLIP	20371350
MIRT565722	hsa-miR-592	PAR-CLIP	20371350
MIRT468479	hsa-miR-1279	PAR-CLIP	20371350
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	20371350
MIRT468478	hsa-miR-569	PAR-CLIP	20371350
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT468474	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT468473	hsa-miR-202-5p	PAR-CLIP	20371350
MIRT468472	hsa-miR-2053	PAR-CLIP	20371350
MIRT468471	hsa-miR-3685	PAR-CLIP	20371350
MIRT468470	hsa-miR-384	PAR-CLIP	20371350
MIRT565721	hsa-miR-606	PAR-CLIP	20371350
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565719	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT565718	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT565709	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT565707	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT565706	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT565705	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT565704	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT565703	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT565702	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT565701	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT565700	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT565699	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT565698	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT565697	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT565696	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT565695	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT565694	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT565693	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT565692	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT565691	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT565690	hsa-miR-3143	PAR-CLIP	20371350
MIRT565689	hsa-miR-4672	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT505698	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561621	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT561620	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT561619	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT561618	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT561617	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT561616	hsa-miR-106a-3p	PAR-CLIP	20371350
MIRT561615	hsa-miR-4503	PAR-CLIP	20371350
MIRT561614	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT561613	hsa-miR-507	PAR-CLIP	20371350
MIRT561612	hsa-miR-557	PAR-CLIP	20371350
MIRT561611	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT542682	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT542681	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT542680	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT542679	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT542678	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT542677	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542676	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT542675	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT542673	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT542674	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT542671	hsa-miR-4317	PAR-CLIP	21572407
MIRT542672	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT505702	hsa-miR-133b	PAR-CLIP	23446348
MIRT505701	hsa-miR-133a-3p	PAR-CLIP	23446348
MIRT505700	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT505699	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT505698	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT505697	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT505696	hsa-miR-622	PAR-CLIP	23446348
MIRT505695	hsa-miR-581	PAR-CLIP	23446348
MIRT505694	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT505693	hsa-miR-3148	PAR-CLIP	23446348
MIRT505692	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT505691	hsa-miR-5587-5p	PAR-CLIP	23446348
MIRT468490	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468489	hsa-miR-3159	PAR-CLIP	23592263
MIRT468488	hsa-miR-5190	PAR-CLIP	23592263
MIRT468487	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468486	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT468485	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT468484	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT468483	hsa-miR-4276	PAR-CLIP	23592263
MIRT468482	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT468481	hsa-miR-4436b-5p	PAR-CLIP	23592263
MIRT468479	hsa-miR-1279	PAR-CLIP	23592263
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT468478	hsa-miR-569	PAR-CLIP	23592263
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT468474	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT468473	hsa-miR-202-5p	PAR-CLIP	23592263
MIRT468472	hsa-miR-2053	PAR-CLIP	23592263
MIRT468471	hsa-miR-3685	PAR-CLIP	23592263
MIRT468470	hsa-miR-384	PAR-CLIP	23592263
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT574441	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT565744	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT565745	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT565743	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT565742	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT565740	hsa-miR-496	PAR-CLIP	20371350
MIRT565741	hsa-miR-3153	PAR-CLIP	20371350
MIRT565739	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT565738	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT565737	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT565736	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT565735	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT565734	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT565733	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT565732	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565731	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT565730	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT565729	hsa-miR-3654	PAR-CLIP	20371350
MIRT565728	hsa-miR-1243	PAR-CLIP	20371350
MIRT565727	hsa-miR-4519	PAR-CLIP	20371350
MIRT565726	hsa-miR-5191	PAR-CLIP	20371350
MIRT565725	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT565724	hsa-miR-3657	PAR-CLIP	20371350
MIRT565723	hsa-miR-4669	PAR-CLIP	20371350
MIRT565722	hsa-miR-592	PAR-CLIP	20371350
MIRT468479	hsa-miR-1279	PAR-CLIP	20371350
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	20371350
MIRT468478	hsa-miR-569	PAR-CLIP	20371350
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT468474	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT468473	hsa-miR-202-5p	PAR-CLIP	20371350
MIRT468472	hsa-miR-2053	PAR-CLIP	20371350
MIRT468471	hsa-miR-3685	PAR-CLIP	20371350
MIRT468470	hsa-miR-384	PAR-CLIP	20371350
MIRT565721	hsa-miR-606	PAR-CLIP	20371350
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565719	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT565718	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT565709	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT565707	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT565706	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT565705	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT565704	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT565703	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT565702	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT565701	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT565700	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT565699	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT565698	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT565697	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT565696	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT565695	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT565694	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT565693	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT565692	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT565691	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT565690	hsa-miR-3143	PAR-CLIP	20371350
MIRT565689	hsa-miR-4672	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT505698	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561621	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT561620	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT561619	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT561618	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT561617	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT561616	hsa-miR-106a-3p	PAR-CLIP	20371350
MIRT561615	hsa-miR-4503	PAR-CLIP	20371350
MIRT561614	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT561613	hsa-miR-507	PAR-CLIP	20371350
MIRT561612	hsa-miR-557	PAR-CLIP	20371350
MIRT561611	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT542682	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT542681	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT542680	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT542679	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT542678	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT542677	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542676	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT542675	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT542673	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT542674	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT542671	hsa-miR-4317	PAR-CLIP	21572407
MIRT542672	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT505702	hsa-miR-133b	PAR-CLIP	23446348
MIRT505701	hsa-miR-133a-3p	PAR-CLIP	23446348
MIRT505700	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT505699	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT505698	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT505697	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT505696	hsa-miR-622	PAR-CLIP	23446348
MIRT505695	hsa-miR-581	PAR-CLIP	23446348
MIRT505694	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT505693	hsa-miR-3148	PAR-CLIP	23446348
MIRT505692	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT505691	hsa-miR-5587-5p	PAR-CLIP	23446348
MIRT468490	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468489	hsa-miR-3159	PAR-CLIP	23592263
MIRT468488	hsa-miR-5190	PAR-CLIP	23592263
MIRT468487	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468486	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT468485	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT468484	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT468483	hsa-miR-4276	PAR-CLIP	23592263
MIRT468482	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT468481	hsa-miR-4436b-5p	PAR-CLIP	23592263
MIRT468479	hsa-miR-1279	PAR-CLIP	23592263
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT468478	hsa-miR-569	PAR-CLIP	23592263
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT468474	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT468473	hsa-miR-202-5p	PAR-CLIP	23592263
MIRT468472	hsa-miR-2053	PAR-CLIP	23592263
MIRT468471	hsa-miR-3685	PAR-CLIP	23592263
MIRT468470	hsa-miR-384	PAR-CLIP	23592263
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT756307	hsa-miR-675-3p	Luciferase reporter assayWestern blottingqRT-PCR	34409922
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT2100368	hsa-miR-146a	CLIP-seq
MIRT2100369	hsa-miR-146b-5p	CLIP-seq
MIRT2100370	hsa-miR-3117-5p	CLIP-seq
MIRT2100371	hsa-miR-3123	CLIP-seq
MIRT2100372	hsa-miR-3925-5p	CLIP-seq
MIRT2100373	hsa-miR-4427	CLIP-seq
MIRT2100374	hsa-miR-4704-5p	CLIP-seq
MIRT2100375	hsa-miR-4775	CLIP-seq
MIRT2325126	hsa-miR-3074-3p	CLIP-seq
MIRT2325127	hsa-miR-4719	CLIP-seq
MIRT2394246	hsa-miR-1262	CLIP-seq
MIRT2394247	hsa-miR-3189-3p	CLIP-seq
MIRT2394248	hsa-miR-425	CLIP-seq
MIRT2394249	hsa-miR-4701-3p	CLIP-seq
MIRT2394250	hsa-miR-502-5p	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
HSF1	Unknown	23388456

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25263562, 26449471
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	25263562
GO:0005737	Component	Cytoplasm	IEA
GO:0016239	Process	Positive regulation of macroautophagy	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016684	Function	Oxidoreductase activity, acting on peroxide as acceptor	IBA
GO:0031932	Component	TORC2 complex	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	25263562
GO:0038203	Process	TORC2 signaling	IEA
GO:0042149	Process	Cellular response to glucose starvation	IEA
GO:0042149	Process	Cellular response to glucose starvation	IMP	25263562
GO:0042593	Process	Glucose homeostasis	IEA
GO:0046626	Process	Regulation of insulin receptor signaling pathway	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0061700	Component	GATOR2 complex	IDA	25263562, 26449471
GO:0070728	Function	L-leucine binding	IBA
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071233	Process	Cellular response to L-leucine	IBA
GO:1901031	Process	Regulation of response to reactive oxygen species	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	25263562
GO:1990253	Process	Cellular response to leucine starvation	IBA

MIM	HGNC	e!Ensembl
607768	23060	ENSG00000149212

P58005

Protein name

Sestrin-3 (EC 1.11.1.-)

Protein function

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04636	PA26	39 → 491	PA26 p53-induced protein (sestrin)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12607115}.

Sequence

MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTN
FLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQ
CSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKT
GENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLAND
NNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFV
VSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHG
FSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDY
DYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAEL
LYALRAITRHLT

Sequence length

492

Interactions

View interactions

	KEGG		Reactome
	p53 signaling pathway Longevity regulating pathway		TP53 Regulates Metabolic Genes

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Ovarian serous cystadenocarcinoma	Benign	rs182315158	RCV005908500
Sarcoma	Benign	rs182315158	RCV005908499
Uterine corpus endometrial carcinoma	Benign	rs182315158	RCV005908501

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	31217489
Arthritis Rheumatoid	Associate	39930543
Atrial Fibrillation	Stimulate	28397812
Carcinoma Hepatocellular	Associate	34409922, 38305606
Carcinoma Non Small Cell Lung	Associate	27881463
Carotid Stenosis	Associate	32626541
Colorectal Neoplasms	Associate	25973791
Diabetes Mellitus Type 2	Stimulate	24129397
Endometrial Neoplasms	Associate	31073887
Fatigue	Associate	29220067
Fatigue	Inhibit	29325451
Graft vs Host Disease	Associate	33082554
Hypertension	Stimulate	32626541
Inflammation	Associate	39217398
Leukemia	Associate	36703207
Lung Neoplasms	Associate	27881463
Mycosis Fungoides	Associate	36400759
Neuroblastoma	Associate	28869600, 31591479
Parkinson Disease	Associate	31217489
Virus Diseases	Associate	31217489

SESN3 (sestrin 3)